Typical and Aberrant Functional Brain Flexibility: Lifespan Development and Aberrant Organization in Traumatic Brain Injury and Dyslexia

Abstract

Intrinsic functional connectivity networks derived from different neuroimaging methods and connectivity estimators have revealed robust developmental trends linked to behavioural and cognitive maturation. The present study employed a dynamic functional connectivity approach to determine dominant intrinsic coupling modes in resting-state neuromagnetic data from 178 healthy participants aged 8–60 years. Results revealed significant developmental trends in three types of dominant intra- and inter-hemispheric neuronal population interactions (amplitude envelope, phase coupling, and phase-amplitude synchronization) involving frontal, temporal, and parieto-occipital regions. Multi-class support vector machines achieved 89% correct classification of participants according to their chronological age using dynamic functional connectivity indices. Moreover, systematic temporal variability in functional connectivity profiles, which was used to empirically derive a composite flexibility index, displayed an inverse U-shaped curve among healthy participants. Lower flexibility values were found among age-matched children with reading disability and adults who had suffered mild traumatic brain injury. The importance of these results for normal and abnormal brain development are discussed in light of the recently proposed role of cross-frequency interactions in the fine-grained coordination of neuronal population activity.

Reconfiguration of αmplitude driven dominant coupling modes (DoCM) mediated by α-band in adolescents with schizophrenia spectrum disorders

“…Additionally, we observed a significantly lower global FI in SSDs compared to HC only in amplitude driven DoCM. In a recent lifespan study with healthy controls, we found aberrant FI for two groups, a dyslexic group and a mild traumatic brain injury (Dimitriadis et al, 2019). FI can be seen as a global index of the normal multiplexity behavior of nested oscillations.…”

Reconfiguration of Amplitude Driven Dominant Coupling Modes (DoCM) mediated by α-band in Adolescents with Schizophrenia Spectrum Disorders

“…Additionally, we observed a significant lower global FI in SSDs compared to HC only in amplitude driven DoCM. In a recent lifespan study with healthy controls, we found aberrant FI for two groups, a dyslexic group and a mild traumatic brain injury (Dimitriadis et al, 2019). FI can be seen as a global index of the normal multiplexity behaviour of nested oscillations.…”

Greek High Phenolic Early Harvest Extra Virgin Olive Oil Reduces the Over-Excitation of Information-Flow Based on Dominant Coupling Mode (DoCM) Model in Patients with Mild Cognitive Impairment: An EEG Resting-State Validation Approach

“…In our previous study, we reported for the very first time that a long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to the MeDi group [7]. We adopted our DoCM model, which incorporates into a dFCG both the dominant coupling mode and its functional strength between every pair of EEG sensors and across experimental time [43,[50][51][52][53][54][55][56][57][58]. We detected a significant higher postintervention reduction of NI (ΔΝΙ Total and α ) for the HP-EH-EVOO compared to the MP-EVOO and MeDi groups.…”

“…This section will briefly describe our dominant intrinsic coupling model (DoCM) demonstrated in the whole repertoire of functional neuroimaging modalities [41,43,[49][50][51][52][53][54][55][56][57][58].…”

“…We estimated dynamic functional connectivity graph (dFCG) within and between the seven studying frequency bands {δ, θ, α1, α2, β1, β2, γ} defined, respectively, within the ranges {0. [41,43,[49][50][51][52][53][54][55][56][57][58]. We finally analyzed 75 secs across subjects and conditions defined as the maximum consistent experimental time across the participants.…”