Reconfiguration of Amplitude Driven Dominant Coupling Modes (DoCM) mediated by α-band in Adolescents with Schizophrenia Spectrum Disorders

Dimitriadis, Stavros I.

doi:10.1101/2020.06.02.20118851

Cited by 1 publication

(1 citation statement)

References 99 publications

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“…To correct the effects of multiple comparisons, p -values were adjusted using the false discovery rate (FDR) method (Benjamini and Hochberg, 1995; Dimitriadis et al, 2015). A threshold of significance q was set such that the expected fraction of false positives was restricted to q ≤ 0.01 (Dimitriadis, 2021; Dimitriadis et al, 2015). The whole procedure was repeated separately across filtering methods, connectivity estimators, and scans.…”

Section: Methodsmentioning

confidence: 99%

Assessing The Repeatability of Multi-Frequency Multi-Layer Brain Network Topologies Across Alternative Researcher’s Choice Paths

Dimitriadis

2021

Preprint

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There is a growing interest in the neuroscience community on the advantages of multimodal neuroimaging modalities. Functional and structural interactions between brain areas can be represented as a network (graph) allowing us to employ graph-theoretic tools in multiple research directions. Researchers usually treated brain networks acquired from different modalities or different frequencies separately. However, there is strong evidence that these networks share complementary information while their interdependencies could reveal novel findings. For this purpose, neuroscientists adopt multilayer networks, which can be described mathematically as an extension of trivial single-layer networks. Multilayer networks have become popular in neuroscience due to their advantage to integrate different sources of information. We can incorporate this information from different modalities (multi-modal case), from different frequencies (multi-frequency case), or a single modality following a dynamic functional connectivity analysis (multi-layer, dynamic case). Researchers already used multi-layer networks to model brain disorders, to detect key hubs related to a specific function, to reveal structural-functional relationships, and to define more precise connectomic biomarkers related to brain disorders. However, the construction of a multilayer network depends on the selection of multiple preprocessing steps that can affect the final network topology. Here, we analyzed the fMRI dataset from a single human performing scanning over a period of 18 months (84 scans in total). We focused on assessing the reproducibility of multi-frequency multilayer topologies exploring the effect of two filtering methods for extracting frequencies from BOLD activity, three connectivity estimators, with or without a topological filtering scheme, and two spatial scales. Finally, we untangled specific combinations of researchers choices that yield repeatable topologies, giving us the chance to recommend best practices over consistent topologies.

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