Types of garlic and their anticancer and antioxidant activity: a review of the epidemiologic and experimental evidence

Hershberger, Pamela A.; Freudenheim, Jo L.; Mammen, Manoj J.; Blair, Rachael Hageman; Aga, Diana S.; Farhat, Zeinab

doi:10.1007/s00394-021-02482-7

Cited by 47 publications

(34 citation statements)

References 141 publications

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“…Numerous in vitro studies showed a high cytotoxic activity of the active compounds (OSCs, flavonoids, saponins) found in Allium vegetables, which currently allows for further investigations regarding the development of new anticancer drugs. However, the presence of particular active compounds is also associated with the form in which the vegetable is served-for instance, crushed garlic contains significant amounts of different OSCs, while when it is cooked, it mostly contains only diallyl disulfide (DADS) and diallyl trisulfide (DATS) (Figures 1 and 2) [12]. Except for OSCs, both of the abovementioned garlic derivatives-DADS and DATSpresent anticancer properties (inhibition of mutagenesis and cellular proliferation, induction of apoptosis and cell cycle arrest, prevention of oxidative stress and damage) and are investigated as possible chemopreventive agents.…”

Section: Introductionmentioning

confidence: 99%

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Forma

Chilimoniuk

Januszewski

et al. 2021

Gastroenterology Insights

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Herbal medicine is currently widely practiced, since natural resources are reported to alleviate side effects during oncological treatment while modifying cancer cell responses at the same time. Allium vegetables and their constituents have recently been extensively investigated due to the numerous possible beneficial properties, establishing them as an additional treatment modality in different cancers. According to the epidemiological evidence, as well as many in vivo and in vitro studies, the abovementioned substances seem to be effective in the prevention and inhibition of the progression of carcinogenesis. Due to high concentrations of organosulfur compounds, which exhibit anticarcinogenic, antimicrobial, as well as anti-inflammatory properties, Allium constituents are believed to constitute a promising prevention and supportive therapy for oncological patients. Besides, it was demonstrated that a combination of Allium extracts with chemotherapy provided satisfactory clinical outcomes while at the same time being cost-effective. The aim of this review was to present and discuss currently investigated Allium extracts and their effects on several gastrointestinal cancers including gastric, colon, liver, esophageal, and pancreatic cancer.

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Section: Introductionmentioning

confidence: 99%

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Forma

Chilimoniuk

Januszewski

et al. 2021

Gastroenterology Insights

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“…ere are some clinical trials focusing on garlic and its biological effects, including anticancer, anti-inflammatory, antioxidant, and antiviral activities [64,[171][172][173]. ese clinical studies have shown that garlic can be used as an adjunct in the management of several diseases, but with limited effects.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound

Song

Yue

Nie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Garlic is widely accepted as a functional food and an excellent source of pharmacologically active ingredients. Diallyl disulfide (DADS), a major bioactive component of garlic, has several beneficial biological functions, including anti-inflammatory, antioxidant, antimicrobial, cardiovascular protective, neuroprotective, and anticancer activities. This review systematically evaluated the biological functions of DADS and discussed the underlying molecular mechanisms of these functions. We hope that this review provides guidance and insight into the current literature and enables future research and the development of DADS for intervention and treatment of multiple diseases.

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“…OSCs inhibit the development of cancer cells by several pathways including inhibition of metabolism, inhibition of angiogenesis, and cell cycle arrest. These compounds are classified into water-soluble OSCs such as S-Allyl Mercaptocysteine and S-Allyl Cysteine and oil-soluble OSCs, such as diallyl disulfide, diallyl sulfide, diallyl trisulfide, ajoene, and dithiins [127]. Numerous organosulfur compounds are declared to have potent antioxidant capacity.…”

Section: Organosulfur Compoundsmentioning

confidence: 99%

Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

Fatima¹,

Baqri²,

Alsulimani

et al. 2021

Antioxidants

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Oxygen is indispensable for most organisms on the earth because of its role in respiration. However, it is also associated with several unwanted effects which may sometimes prove fatal in the long run. Such effects are more evident in cells exposed to strong oxidants containing reactive oxygen species (ROS). The adverse outcomes of oxidative metabolism are referred to as oxidative stress, which is a staple theme in contemporary medical research. Oxidative stress leads to plasma membrane disruption through lipid peroxidation and has several other deleterious effects. A large body of literature suggests the involvement of ROS in cancer, ageing, and several other health hazards of the modern world. Plant-based cures for these conditions are desperately sought after as supposedly safer alternatives to mainstream medicines. Phytochemicals, which constitute a diverse group of plant-based substances with varying roles in oxidative reactions of the body, are implicated in the treatment of cancer, aging, and all other ROS-induced anomalies. This review presents a summary of important phytochemicals extracted from medicinal plants which are a part of Indian ethnomedicine and Ayurveda and describes their possible therapeutic significance.

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Types of garlic and their anticancer and antioxidant activity: a review of the epidemiologic and experimental evidence

Cited by 47 publications

References 141 publications

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

The Potential Application of Allium Extracts in the Treatment of Gastrointestinal Cancers

Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound

Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer

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