Types and Clinical Profile of Rickets in a Tertiary Care Hospital

Akhter, Shohela; Islam, Mohammed Mahbubul; Mamun, Mustafa; Rahman, Shahana A; Kawser, Choudhury Ali

doi:10.3329/bsmmuj.v2i1.3703

Cited by 1 publication

(3 citation statements)

References 8 publications

(7 reference statements)

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“…Patient with clinical rickets confirmed by radiological and biochemical features and who were not on any treatment prior to presentation were provisionally included in this study. Among all children, 66.6% were male which was also consistent with the studies of Shohela et al 23 and Siddiqui et al 24 . Because boys tend to have greater linear bone growth than girls, rickets occur more frequently in boys than in girls.…”

Section: Discussionsupporting

confidence: 90%

“…The current study found that common clinical manifestations of nutritional rickets were widening of wrist (96.7%), bowing of lower limbs (60%), rachitic rosary (53%), protruded abdomen (43.3%) and Shohela et al 23 found that 90% of child had widening of wrist, 80% had rachitic rosary, 45% had genu valgum, these findings support the result of current study. Majeed et al 27 and Siddiqui et al 24 described the nearly similar clinical findings in their studies in Pakistan.…”

Section: Discussionsupporting

confidence: 88%

“…Mean age of the children in this study was 35.83 months with the age range of 9 months to 96 months. Shohela et al 23 in their study found the mean age of rickets as 49.36 months with age range 9 months to 156 months. This mean age was more or less consistent with this study.…”

Section: Discussionmentioning

confidence: 90%

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Effect of vitamin D and calcium alone or in combination in the treatment of nutritional rickets

Yasmin

Chowdhury

et al. 2020

Birdem Med J

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Background: Nutritional rickets has emerged as a public health problem in Bangladesh during the past two decades, with up to 8% of children being clinically affected in some areas. Insufficiency of vitamin D and dietary calcium is thought to be the underlying cause. Vitamin D administered with or without calcium is commonly regarded as the mainstay of treatment. Calcium alone or in combination with vitamin D has also been used in the treatment of nutritional rickets. So this study was done to assess the effects of vitamin D, calcium or combination of vitamin D and calcium for the treatment of nutritional rickets in Bangladeshi children. Methods: This open labeled randomized comparative study was done in the Department of Paediatrics, Sylhet MAG Osmani Medical College Hospital from July 1, 2010 to June 30, 2012 A total 48 rickets patient was enrolled in this study. After selection of cases patients were divided in to three groups by lottery method. Group A received single i/m dose of vitamin D 4,00,000 IU (2,00,000 IU in each buttock), Group B received calcium (750 mg per day) for 6 weeks and Group C received both calcium (750 mg per day) for 6 weeks and single i/m dose of vitamin D 4,00,000 IU (2,00,000 IU in each buttock). Response was evaluated by serum alkaline phosphatase level and using 10-point radiographic score developed by Thacher and colleagues at baseline, 6 weeks, and 12 weeks. Results: Mean age of the study participants was 35.83 months. Male to female ratio was 2:1. The radiographic score was significantly improved in first and second follow up (p<0.001) in all groups. But there was significant difference of improvement in Group C than Group A and Group B. In Group C, the percent reduction from base to first follow up was 80.05±7.04 and 90.65±3 in second follow up which showed quick improvement in combination therapy. Serum alkaline phosphatase also significantly reduced in all three groups. Conclusion: Combination use of vitamin D and calcium in the treatment of nutritional rickets is more effective than prescribing either vitamin D or calcium alone. Birdem Med J 2021; 11(1): 39-46

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%