Type specific seroprevalence of HSV-1 and HSV-2 in four geographical regions of Poland

Smith, Jennifer S.; Rosińska, Magdalena; Trzcińska, Agnieszka; Pimenta, Jeanne M.; Litwińska, B; Siennicka, Joanna

doi:10.1136/sti.2005.015446

Cited by 24 publications

(24 citation statements)

References 30 publications

(27 reference statements)

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“…In our study, age showed the strongest correlation with HSV-2 seroprevalence in both sexes, which is in agreement with most previous studies and reviews [5, 6, 23–25, 27, 30, 32, 33, 37]. …”

Section: Discussionsupporting

confidence: 93%

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

et al. 2016

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BackgroundHerpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcer disease (GUD) worldwide. Mother to child transmission causes high morbidity and mortality among infants. Russia is on the brink of a generalized HIV-epidemic, but Arkhangelsk is still a low-prevalence area. HSV-2 infection is associated with a three-fold increased risk of HIV-infection. The evidence on the seroprevalence of HSV-2 in Russia is limited. The aim of this study was to assess HSV-2 seroprevalence and correlates among young adults in the city of Arkhangelsk.Methods1243 adults aged 18-39 years participated in a cross-sectional population-based study, recruited by a public opinion agency applying a quota sampling method to achieve a data set with similar age- and sex-distribution as the population in Arkhangelsk. All participants completed a standardized, self-administrated questionnaire and were tested for HSV-2. Associations between HSV-2 seropositivity and selected sociodemographic and behavioral factors, and self-reported history of sexually transmitted infections (STIs) were studied by multivariable logistic regression.ResultsHSV-2 seroprevalence was 18.8 %: 12.2 % (95 % confidence interval, CI 9.7-15.2) among men and 24.0 % (95 % CI 20.1-27.3) among women. Among men, HSV-2 positivity was associated with being divorced/widowed (OR = 2.85, 95 % CI 1.06-7.70), cohabitation (OR = 2.45, 95 % CI 1.07-5.62), and a history of STIs (OR = 2.11, 95 % CI 1.14-3.91). In women, HSV-2 positivity was associated with high income (OR = 3.11, 95 % CI 1.45-6.71) and having a lifetime number of sexual partners between 2 and 5 (OR = 2.72, 95 % CI 1.14-6.51), whereas sexual debut at age 18 years or older was inversely associated with the outcome (OR = 0.47, 95 % CI 0.31-0.72). In both sexes, increasing age was the strongest correlate of HSV-2 seropositivity in multivariable analyses.ConclusionThe HSV-2 seroprevalence was twice as high in women than in men and increased with age in both sexes, and similar to that reported from high-prevalence countries in Europe and the USA. The high prevalence of HSV-2 among women in childbearing age reveals the potential for HSV-2 transmission from mothers to infants and increased risk of acquisition HIV-infection; it also contributes to the burden GUD among both sexes. This emphasizes the public health implications of the HSV-2 epidemic in an urban population in North-West Russia.

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Section: Discussionsupporting

confidence: 93%

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

et al. 2016

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“…22 . In contrast, population-based studies found substantially lower prevalence in Europe 23 and Australia. 24 .…”

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confidence: 75%

Sero-prevalence of herpes simplex type 2 virus (HSV-2) and HIV infection in Kampala, Uganda

Joloba¹,

Kambugu²,

Wasubire³

et al. 2015

Afr H. Sci.

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Background:Prevalence of herpes simplex type 2 virus (HSV-2) is high worldwide. Previous studies in Uganda were rural or in women. We estimated age and sex-specific sero-prevalence of HSV-2 in Kampala, Uganda. Methods: Using two-stage random sampling stratified on population density, a survey of persons 15-65 years was conducted. Type-specific serological tests for HSV-2, HSV-1(HerpeSelect2 and 1 ELISA), HIV (Rapid tests and ELISA), syphilis (RPR and TPHA) were done. Additional prevalence analysis included post-stratification weighting on the Uganda 2002 Census gender distribution. Results: Among 1124 persons, HSV-2 prevalence was 58% (95% CI: 55, 60), HSV-1; 98% (95% CI: 97.6, 99.1), HIV; 17.7% (95% CI: 14.8, 19.2) and syphilis; 1.7% (95% CI: 1.4, 1.9). Weighted HSV-2 prevalence was 53.8% (Women; 63.8%, men; 43.2%), similar to unweighted data. Weighted HIV prevalence was 20.7% in women, 8.6% in men. Of 165 HIV infected persons, 85.4% had HSV-2. Risk factors for HSV-2 were being a woman (OR 2.0; 95% CI: 1.42, 2.78), age (OR 3.3; 95% CI: 2.43, 4.53), education (OR 1.70; 95% CI: 1.34, 2.34) and HIV (OR 4.5; 95% CI: 2.70, 7.50). Conclusion: Prevalence of HSV-2 and HIV was high especially in women. Syphilis was rare. Awareness of herpes was low. Interventions in young people are needed.

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“…Seroepidemiological data from worldwide studies performed during the last decade have estimated the HSV-2 seroprevalence to range from 0% in children to more than 80% in selected populations such as STI cohorts in some African countries (14,36). For Poland, data are scarce, but recently, the prevalence of HSV-2 infection was described to vary between 6.5% and 12% from randomly selected serum samples in four geographic regions in Poland, not including Katowice (37).…”

mentioning

confidence: 99%

Seroprevalences of Herpes Simplex Virus Type 2, Five Oncogenic Human Papillomaviruses, and Chlamydia trachomatis in Katowice, Poland

Görander

Lagergård

Romanik

et al. 2008

Clin Vaccine Immunol

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Herpes simplex virus type 2 (HSV-2), human papillomaviruses (HPVs), and Chlamydia trachomatis are the most common pathogens causing sexually transmitted infections (STIs). There is limited information about the prevalences of these STIs in Poland. Here, we estimated the occurrence of immunoglobulin G (IgG) antibodies against HSV-2, HPV, and C. trachomatis in 199 blood donors and 110 patients of both genders attending an STI clinic in Katowice in southern Poland. The seroprevalences of HSV-2 were 5% for blood donors and 14% in the STI cohort. The seroprevalences of the five potentially oncogenic HPV types 16, 18, 31, 35, and 51 were 15%, 7%, 5%, 5%, and 17%, respectively, in blood donors and 37%, 8%, 12%, 5%, and 21%, respectively, in the STI cohort. The majority of HPV-infected individuals showed antibodies against more than one type, i.e., had been infected with multiple HPV types. Anti-C. trachomatis IgG antibodies were detected in 6% of blood donors and 13% of individuals attending the STI clinic. The relatively high prevalence of HPV-51 may have implications for future vaccine programs, as the newly introduced HPV vaccines are based on the potentially oncogenic HPV types 16 and 18.Infections with herpes simplex virus type 2 (HSV-2), human papillomavirus (HPV), and Chlamydia trachomatis are spread sexually, causing considerable morbidity and socioeconomic problems. A number of severe complications are associated with these sexually transmitted infections (STIs). HSV-2 infects the genital mucosa and establishes a life-long infection in sensory ganglia. HSV-2 is the most common cause of genital ulcers, and a strong association between HSV-2 infection and the AIDS epidemic has been described. Local HSV-2 reactivation enhances both HSV-2 and human immunodeficiency virus (HIV) transmission by increasing the number of HIV target cells in the genital mucosa, i.e., cervical immature dendritic cells and CD4 ϩ T cells (34). Furthermore, HSV suppressive therapy significantly reduces genital and plasma HIV-1 RNA levels in dually infected women (28). Seroepidemiological data from worldwide studies performed during the last decade have estimated the HSV-2 seroprevalence to range from 0% in children to more than 80% in selected populations such as STI cohorts in some African countries (14, 36). For Poland, data are scarce, but recently, the prevalence of HSV-2 infection was described to vary between 6.5% and 12% from randomly selected serum samples in four geographic regions in Poland, not including Katowice (37).HPV is the most commonly spread STI (40). Infection with oncogenic HPV types is the dominating cause of cervical cancer, which is globally the second most common cancer among women. There is great variation in the prevalence of HPV infection depending on different population-based factors such as age, gender, number of sexual partners, and geographic region. The oncogenic HPV-16 and HPV-18 are the bestdocumented types, with reported seroprevalences of 3% to 52% in adult populations worldwide (9,21,43). Most studies...

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Type specific seroprevalence of HSV-1 and HSV-2 in four geographical regions of Poland

Cited by 24 publications

References 30 publications

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study

Sero-prevalence of herpes simplex type 2 virus (HSV-2) and HIV infection in Kampala, Uganda

Seroprevalences of Herpes Simplex Virus Type 2, Five Oncogenic Human Papillomaviruses, and Chlamydia trachomatis in Katowice, Poland

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