Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction

Platt, Daniel E.; Hariri, Essa; Salameh, Pascale; Merhi, Mahmoud; Sabbah, Nada; Helou, Mariana; Mouzaya, Francis; Nemer, Rita; Al-Sarraj, Yasser; El‐Shanti, Hatem; Abchee, Antoine; Zalloua, Pierre

doi:10.1186/s13098-017-0218-0

Cited by 26 publications

(18 citation statements)

References 38 publications

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“…hyperinsulinemia, in response to insulin resistance [ 9 ]. Under diabetic conditions, elevated Hcy level is often observed [ 34 ]. The present study provides novel findings that HMLF diet can gradually induce insulin resistance and hyperglycemia in non-diabetic C57BL/6 mice, implying that HMLF diet could alter glucose homeostasis.…”

Section: Discussionmentioning

confidence: 99%

A high methionine and low folate diet alters glucose homeostasis and gut microbiome

Cheng

Wang

et al. 2021

Biochemistry and Biophysics Reports

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Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine low folate (HMLF) diet chronically causes HHcy by accumulating homocysteine in the systemic circulation. Elevated Hcy level is also associated with the incidence of diabetes mellitus. However, very few studies focus on the impact of HMLF diet on glucose homeostasis, and that on gut microbiome profile. HHcy was induced by feeding C57BL/6 mice a HMLF diet for 8 weeks. The HMLF diet feeding resulted in a progressive body weight loss, and development of slight glucose intolerance and insulin resistance in HHcy mice. Notably, the HMLF diet alters the gut microbiome profile and increases the relative abundance of porphyromonadaceae family of bacteria in HHcy mice. These findings provide new insights into the roles of dysregulated glucose homeostasis and gut flora in the pathogenesis of HHcy-related complications.

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Section: Discussionmentioning

confidence: 99%

A high methionine and low folate diet alters glucose homeostasis and gut microbiome

Cheng

Wang

et al. 2021

Biochemistry and Biophysics Reports

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“…Different alphabet shows a significant difference with other groups (p < .05). Groups with a similar alphabet on each column are not significantly different, but different alphabets indicate a significant difference between groups been proposed in the literature (Huang, Ren, Huang, & Li, 2013;Platt et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

et al. 2020

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This study aimed to evaluate the effect of two doses of cyclohexane extract of walnut leaves on total homocysteine, lipids profiles, and indices of oxidative stress including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and malondialdehyde (MDA) in diabetic rats. Diabetes was induced by a single intraperitoneal (IP) injection of streptozotocin (50 mg/kg BW). Twenty‐eight male Sprague Dawley rats were randomly divided into four groups, group I: control (received sesame oil as vehicle), group II: diabetic control (received sesame oil), group III and IV: diabetic rats treated by 150 and 250 mg/kg body weight (BW) per day extract of walnut leaves, respectively. All groups were treated for 28 days via oral gavage. Fasting blood glucose (FBG) level and body weight measured before injection, 3 days after injection, and on days 0, 7, 14, 21, and 28 of treatment. At the end the 28th day of the experiment, blood samples collected via heart puncture and the sera were used for estimation of the above‐mentioned parameters. The results showed a decrease in FBS, TC, TG, LDL‐c, VLDL‐c, homocysteine, and MDA level and increase in the level of HDL‐c in diabetics treated by walnut leave extracts in a dose‐dependent manner after 28 days. The activity of antioxidant enzymes significantly increased in treated groups compared with diabetic control. It can be concluded that cyclohexane extract of walnut leaves has an overall beneficial effect on body weight, fasting blood glucose, lipids profile, antioxidant enzyme activities, and homocysteine.

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“…Hcy levels were significantly increased when these rats with diabetes received insulin. These results strongly suggest a regulatory role of insulin in the hepatic trans-sulfuration pathway that metabolizes Hcy [13].…”

Section: Discussionmentioning

confidence: 68%

Estimation of Serum Homocysteine and Vitamin B12 in Type 2 Diabetes Mellitus Patients

Sadaria¹,

Vasava²,

Bhalgariya³

et al. 2019

IJBcRR

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Background: Diabetes mellitus is a common metabolic disorder characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Homocysteine (Hcy) is a risk factor strongly linked to cardiovascular complications in Type 2 Diabetes mellitus (T2DM). Hcy requires 5-methyltetrahydrofolate as methyl donor and vitamin B12 as a co-factor. So, Vitamin B12 deficiency will lead to hyperhomocysteinemia. Biochemical and clinical vitamin B12 deficiency has been demonstrated to be highly prevalent among patients with type 1 and type 2 diabetes mellitus. Aims: To assess the serum homocysteine and vitamin B12 levels in type 2 Diabetes mellitus patients. Methodology: The present case control study was conducted at Dhiraj hospital, Piparia, Vadodara, Gujarat, India in which 80 subjects were enrolled, out of which 40 were cases of type 2 diabetes mellitus patients and 40 were controls. The age group for the study was 35 to 70 years. Blood samples were drawn to measure RBS, HbA1c, serum homocysteine and vitamin B12. Interpretation of data was done using Medcalc software. Results: The mean levels of serum homocysteine was higher in T2DM patients than normal healthy individuals, difference between them was statistically highly significant (p<0.0001). The mean levels of vitamin B12 was lower in T2DM patients than normal healthy individuals, difference between them was statistically highly significant (p<0.0001). There is no correlation found between Homocysteine, vitamin B12 & HbA1c. Conclusion: A significant increase in serum Hcy level was observed in T2DM patients in our study. Raised serum Homocysteine is considered as an early marker of B12 deficiency. Hyperhomocysteinemia will lead to cardiovascular complications. Therefore, the hyperhomocysteinemia could serve as another important marker of poor diabetic control and developing complications.

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Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction

Cited by 26 publications

References 38 publications

A high methionine and low folate diet alters glucose homeostasis and gut microbiome

A high methionine and low folate diet alters glucose homeostasis and gut microbiome

Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

Estimation of Serum Homocysteine and Vitamin B12 in Type 2 Diabetes Mellitus Patients

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