Type I Interferon Limits the Capacity of Bluetongue Virus To Infect Hematopoietic Precursors and Dendritic Cells
            <i>In Vitro</i>
            and
            <i>In Vivo</i>

Rodríguez-Calvo, Teresa; Rojas, José M.; Martı́n, Verónica; Sevilla, Noemı́

doi:10.1128/jvi.02697-13

Cited by 13 publications

(12 citation statements)

References 40 publications

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“…Together with its ability to modulate IFN synthesis (38), BTV would then ensure a powerful inhibition of the cellular response. Several studies have suggested that IFN-I is an important factor to limit BTV replication and dissemination and control infection (52)(53)(54). By inhibiting both IFN-I synthesis and signaling pathways, BTV would then promote the establishment of an infection.…”

Section: Discussionmentioning

confidence: 99%

Dual Modulation of Type I Interferon Response by Bluetongue Virus

Doceul

Chauveau

Lara

et al. 2014

J Virol

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Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus that causes an economically important disease in ruminants. BTV infection is a strong inducer of type I interferon (IFN-I) in multiple cell types. It has been shown recently that BTV and, more specifically, the nonstructural protein NS3 of BTV are able to modulate the IFN-I synthesis pathway. However, nothing is known about the ability of BTV to counteract IFN-I signaling. Here, we investigated the effect of BTV on the IFN-I response pathway and, more particularly, the Janus tyrosine kinase (JAK)/signal transducer and activator of transcription protein (STAT) signaling pathway. We found that BTV infection triggered the expression of IFN-stimulated genes (ISGs) in A549 cells. However, when BTV-infected cells were stimulated with external IFN-I, we showed that activation of the IFN-stimulated response element (ISRE) promoter and expression of ISGs were inhibited. We found that this inhibition involved two different mechanisms that were dependent on the time of infection. After overnight infection, BTV blocked specifically the phosphorylation and nuclear translocation of STAT1. This inhibition correlated with the redistribution of STAT1 in regions adjacent to the nucleus. At a later time point of infection, BTV was found to interfere with the activation of other key components of the JAK/STAT pathway and to induce the downregulation of JAK1 and TYK2 protein expression. Overall, our study indicates for the first time that BTV is able to interfere with the JAK/STAT pathway to modulate the IFN-I response. IMPORTANCE Bluetongue virus (BTV) causes a severe disease in ruminants and has an important impact on the livestock economy in areas of

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Section: Discussionmentioning

confidence: 99%

Dual Modulation of Type I Interferon Response by Bluetongue Virus

Doceul

Chauveau

Lara

et al. 2014

J Virol

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“…Presence of macrocytic erythrocytes with no other evidence of regenerative anaemia has been described in horses or cats (Thrall, 2004). In the latter species, the findings have been associated with potential viral effect on bone marrow (Munoz, 2005); indeed, Bluetongue virus has been found to be able to destroy haemopoetic stem cells (Rodriguez-Calvo et al, 2014). Findings in such cases would be compatible with the results of haematological tests .…”

Section: Discussionmentioning

confidence: 83%

Experiences from the 2014 outbreak of bluetongue in Greece

Vasileiou

Fthenakis

Amiridis

et al. 2016

Small Ruminant Research

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a b s t r a c tObjective of this paper was to review relevant work and to present a general account of the bluetongue outbreak, which occurred in Greece in 2014. In total, 2895 outbreaks of the disease have been reported by the veterinary authorities of Greece; sheep, goats and cattle were affected with officially reported morbidity rates of 11.0%, 2.0% and 3.5%, respectively. No vaccinations were allowed and conservative measures were implemented to attempt to limit the disease, which at the end had expanded throughout the country. In field investigations, a significantly higher bluetongue morbidity rate (27.5%) in sheep has been reported. During that work, clinical anaemia was encountered, which was characterised as macrocytic, hypochromic, regenerative and non-haemolytic. Other investigations, which are reviewed in this paper, have described an outbreak of Citrobacter freundii-associated enteritis in newborn kids, offspring of goats subclinically infected with Bluetongue virus, increased rate of early embryonic deaths, reduced conception rates, increased incidence risk of mastitis and reduced milk yield in herds of subclinicallyinfected cattle and detection of the virus from hunter-harvested tissue samples of roe-deer. In 2015, vaccines against the disease have been licenced; vaccinations started in May 2015. Then, in 2015, only one outbreak of the disease was confirmed, which could have been the result of a combination of reasons acting concurrently to prevent further cases.

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“…Mammalian innate immunity against viral infection critically depends on a successful type I interferon response (Rodriguez-Calvo et al, 2014). To circumvent this innate protective response, many viruses have evolved mechanisms to subvert the IFN-α/β pathway (Didcock et al, 1999;Fensterl et al, 2005;Wang et al, 2011;Wang et al, 2010;Wang et al, 2000).…”

Section: Discussionmentioning

confidence: 99%