Type 5 phosphodiesterase expression in the human vagina

d’Amati, Giulia; Gioia, Cira Di; Bologna, Mauro; Giordano, Daniela; Giorgi, Mauro; Dolci, Susanna; Jannini, Emmanuele A.

doi:10.1016/s0090-4295(02)01663-1

Cited by 134 publications

(91 citation statements)

References 23 publications

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“…In addition to the vagina, PDE5 is also present in the clitoris and the smooth muscles of the labia. Consumption of sildenafil results in hyperpolarization and relaxation of the tissue through the above-mentioned mechanism, and eventually leads to increase in blood flow, hyperemia, and inflation [27,28]. Thus, it is highly effective in females' sexual function, particularly sexual arousal [29].…”

Section: Resultsmentioning

confidence: 99%

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Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Zeinalzadeh

Akbarzadeh

Faridi

et al. 2017

fmpcr

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Background. Female sexual dysfunction is a serious, multifactorial problem which affects women's quality of life. Objectives. This study aimed at assessing the effect of sildenafil citrate on sexual dysfunction among women of reproductive age. Materials and methods. The present randomized clinical trial was conducted on 84 married women between 18 and 40 years old who suffered from sexual dysfunction. The inclusion criteria of the study were being married and between 18-40 years old, obtaining scores ≥ 22 in FSFI, not having a history of hypothyroidism or hyperprolactinemia, and not suffering from dyspareunia or vaginismus. The intervention group was required to consume 50 mg sildenafil citrate 1 hour before sexual intercourse for 5 weeks, and the control group received placebo. FSFI was completed by both study groups before and 5 weeks after the treatment. The data were analyzed through SPSS (v. 18) and paired t-test and independent t-test. Results. Most of the women (67.2%) were between 30 and 40 years old. The study results revealed a significant difference between the two groups regarding the mean scores of sexual desire (p = 0.011), sexual arousal (p = 0.001), lubrication (p = 0.026), orgasm and sexual satisfaction (p < 0.001), and the whole dimension (p < 0.001). Besides, total mean sexual function before and after for the intervention and control groups was 21.1 ± 3.28 vs. 17.22 ± 5.9 (p < 0.001). Conclusion. In this study, sildenafil citrate was effective in enhancing sexual desire, arousal, orgasm, and sexual satisfaction. Of course, more studies need to be conducted on this issue.

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Section: Resultsmentioning

confidence: 99%

“…In addition to playing physiological roles in males' sexual responses, this medication can also be effective in females' sexual arousal [8]. Sildenafil citrate is also available under the commercial names Viagra and Revatio.…”

Section: Introductionmentioning

confidence: 99%

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Zeinalzadeh

Akbarzadeh

Faridi

et al. 2017

fmpcr

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“…2 Sildenafil, a PDE5 inhibitor, can significantly increase genital blood flow and lubrication in ovariectomized animals. 3 The proposed mechanism by which this occurs is selective inhibition of PDE5, an enzyme that normally inhibits cyclic guanosine monophosphate (cGMP).…”

Section: Discussionmentioning

confidence: 99%

“…Nitric oxide normally stimulates the production of cGMP, a nucleotide able to relax smooth muscle in penile erectile tissue. 2,4 The PDE5 expression has been noted in the clitoral erectile tissue and periurethral vaginal tissue in human vagina. 2 Studies have focused on the use of sildenafil and its effects on human sexual function in relation to neurogenic disease.…”

Section: Discussionmentioning

confidence: 99%

“…2,4 The PDE5 expression has been noted in the clitoral erectile tissue and periurethral vaginal tissue in human vagina. 2 Studies have focused on the use of sildenafil and its effects on human sexual function in relation to neurogenic disease. 5,6 In regards to women with spinal cord injury, sildenafil improved vaginal pulse amplitude, a measurement of vaginal blood flow, with increased levels of sexual stimulation.…”

Section: Discussionmentioning

confidence: 99%

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Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5‐S1 intervertebral disk rupture: A case report

Ferrara

Zaslau

2007

Int J of Urology

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Female sexual dysfunction can be founded by disorders of sexual desire, arousal, orgasm, and sexual pain. Physiologic sexual dysfunction can, in many cases, be the result of impaired neurovascular tone to the clitoris and vagina. The vagina and clitoris both contain erectile tissue and phosphodiesterase type 5 (PDE5). Accordingly, the use of sildenafil, a PDE5 inhibitor, has been studied in relation to neurogenic female sexual dysfunction. The present case report addresses neurogenic female sexual dysfunction from the result of a ruptured L5-S1 intervertebral disk. The patient was treated with sildenafil, and her symptoms were recorded using a Female Sexual Function Index score. Discussion of the use of sildenafil in women, with an emphasis on female neurovascular sexual physiology and function, is reviewed.

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Interventions for treating sexual dysfunction in patients with chronic kidney disease

Vecchio

Navaneethan

Johnson³

et al. 2010

Cochrane Database of Systematic Reviews

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Type 5 phosphodiesterase expression in the human vagina

Cited by 134 publications

References 23 publications

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5‐S1 intervertebral disk rupture: A case report

Interventions for treating sexual dysfunction in patients with chronic kidney disease

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