Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5‐S1 intervertebral disk rupture: A case report

Ferrara, Dean; Zaslau, Stanley

doi:10.1111/j.1442-2042.2007.01518.x

Cited by 8 publications

(7 citation statements)

References 6 publications

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“…Although the treatment of FSAD has various options including hormone therapy, phosphodiesterase (PDE) inhibitors and alphablockers, mostly through enhancement of the vaginal blood flow [6,[8][9][10][11][12][13], they possess undesired side effects following their systemic administration. For examples, since PDE inhibitors and ablockers affected the systemic blood pressure and cardiac function, their clinical usages often resulted in adverse activities in cardiovascular regulation.…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of vaginal films for mucosal delivery of nitric oxide

2009

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Section: Introductionmentioning

confidence: 99%

In vivo evaluation of vaginal films for mucosal delivery of nitric oxide

2009

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“…The data were gathered using the FSFI questionnaire, and showed that the females' sexual function score increased from 48 to 57. Thus, the findings of that study showed that sildenafil citrate increased the subjects' sexual stimulation and lubrication (p < 0.001) [21].…”

Section: Resultsmentioning

confidence: 68%

“…Ferrara and Zaslau (2007) used sildenafil citrate in order to treat sexual dysfunction in women suffering from neurogenic injury (L5-S1 disk herniation). The data were gathered using the FSFI questionnaire, and showed that the females' sexual function score increased from 48 to 57.…”

Section: Resultsmentioning

confidence: 99%

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Zeinalzadeh

Akbarzadeh

Faridi

et al. 2017

fmpcr

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Background. Female sexual dysfunction is a serious, multifactorial problem which affects women's quality of life. Objectives. This study aimed at assessing the effect of sildenafil citrate on sexual dysfunction among women of reproductive age. Materials and methods. The present randomized clinical trial was conducted on 84 married women between 18 and 40 years old who suffered from sexual dysfunction. The inclusion criteria of the study were being married and between 18-40 years old, obtaining scores ≥ 22 in FSFI, not having a history of hypothyroidism or hyperprolactinemia, and not suffering from dyspareunia or vaginismus. The intervention group was required to consume 50 mg sildenafil citrate 1 hour before sexual intercourse for 5 weeks, and the control group received placebo. FSFI was completed by both study groups before and 5 weeks after the treatment. The data were analyzed through SPSS (v. 18) and paired t-test and independent t-test. Results. Most of the women (67.2%) were between 30 and 40 years old. The study results revealed a significant difference between the two groups regarding the mean scores of sexual desire (p = 0.011), sexual arousal (p = 0.001), lubrication (p = 0.026), orgasm and sexual satisfaction (p < 0.001), and the whole dimension (p < 0.001). Besides, total mean sexual function before and after for the intervention and control groups was 21.1 ± 3.28 vs. 17.22 ± 5.9 (p < 0.001). Conclusion. In this study, sildenafil citrate was effective in enhancing sexual desire, arousal, orgasm, and sexual satisfaction. Of course, more studies need to be conducted on this issue.

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“…Another case about sildenafil treatment in neurogenic female sexual dysfunction caused by L5-S1 intervertebral disk rupture in 2007. [ 16 ] We present here addional four cases. Interesting point of our cases is that all disc occurred at the level L5-S1.…”

Section: Discussionmentioning

confidence: 99%

Describing a new syndrome in L5-S1 disc herniation: Sexual and sphincter dysfunction without pain and muscle weakness

Akça

Özdemi̇r

Kanat

et al. 2014

J Craniovert Jun Spine

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Context:Little seems to be known about the sexual dysfunction (SD) in lumbar intervertebral disc herniation.Aims:Investigation of sexual and sphincter dysfunction in patient with lumbar disc hernitions.Settings and Design:A retrospective analysis.Materials and Methods:Sexual and sphincter dysfunction in patients admitted with lumbar disc herniations between September 2012-March 2014.Statistical Analysis Used:Statistical analysis was performed using the Predictive Analytics SoftWare (PASW) Statistics 18.0 for Windows (Statistical Package for the Social Sciences, SPSS Inc., Chicago, Illinois). The statistical significance was set at P < 0.05. The Wilcoxon signed ranks test was used to evaluate the difference between patients.Results:Four patients with sexual and sphincter dysfunction were found, including two women and two men, aged between 20 and 52 years. All of them admitted without low back pain. In addition, on neurological examination, reflex and motor deficit were not found. However, almost all patients had perianal sensory deficit and sexual and sphincter dysfunction. Magnetic resonance imaging (MRI) of three patients displayed a large extruded disc fragment at L5-S1 level on the left side. In fourth patient, there were not prominent disc herniations. There was not statistically significant difference between pre-operative and post-operative sexual function, anal-urethral sphincter function, and perianal sensation score. A syndrome in L5-S1 disc herniation with sexual and sphincter dysfunction without pain and muscle weakness was noted. We think that it is crucial for neurosurgeons to early realise that paralysis of the sphincter and sexual dysfunction are possible in patients with lumbar L5-S1 disc disease.Conclusion:A syndrome with perianal sensory deficit, paralysis of the sphincter, and sexual dysfunction may occur in patients with lumbar L5-S1 disc disease. The improvement of perianal sensory deficit after surgery was counteracted by a trend toward disturbed sexual function. Further researches are needed to explore the extent of this problem.

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Success of sildenafil treatment in neurogenic female sexual dysfunction caused by L5‐S1 intervertebral disk rupture: A case report

Cited by 8 publications

References 6 publications

In vivo evaluation of vaginal films for mucosal delivery of nitric oxide

In vivo evaluation of vaginal films for mucosal delivery of nitric oxide

Effect of sildenafil citrate on women affected by sexual dysfunction referred to health clinics

Describing a new syndrome in L5-S1 disc herniation: Sexual and sphincter dysfunction without pain and muscle weakness

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