Type 4 phosphodiesterase inhibition impairs detection of low odor concentrations in mice

Pho, Vanee; Butman, Michelle L.; Cherry, James A.

doi:10.1016/j.bbr.2005.02.011

Cited by 18 publications

(13 citation statements)

References 26 publications

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“…The olfactory go/no-go test is a sensitive assay of olfactory function, and qualitatively, mice in our task learned and performed within ranges reported by other groups (Bodyak and Slotnick, 1999; Kelliher et al, 2003; Abraham et al, 2004; Lin et al, 2004; Pho et al, 2005; Wesson et al, 2006). Although the targeting of Tph2 caused a nearly complete elimination of 5-HT synthesis, this deficiency does not result in loss of 5-HT neuron cell bodies, as evidenced by their intact expression of aromatic amino acid decarboxylase (Whitney et al, 2016).…”

Section: Discussionsupporting

confidence: 61%

Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

Carlson

Whitney

Gadziola

et al. 2016

eNeuro

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Section: Discussionsupporting

confidence: 61%

Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

Carlson

Whitney

Gadziola

et al. 2016

eNeuro

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“…Interestingly, mice were found to be clearly less sensitive for aliphatic alcohols [28], [29] than for the chemical classes mentioned above. Whether this discrepancy in olfactory sensitivity for different chemical classes is due to differences in their behavioral relevance for the mouse or due to some yet unknown factor remains to be elucidated.…”

Section: Discussionmentioning

confidence: 94%

Olfactory Sensitivity and Odor Structure-Activity Relationships for Aliphatic Carboxylic Acids in CD-1 Mice

Güven¹,

Laska

2012

PLoS ONE

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Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids (ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated. With all 14 odorants, the animals significantly discriminated concentrations as low as 0.03 ppm (parts per million) from the solvent, and with four odorants the best-scoring animals even detected concentrations as low as 3 ppt (parts per trillion). Analysis of odor structure-activity relationships showed that the correlation between olfactory detection thresholds of the mice for the unbranched carboxylic acids and carbon chain length can best be described as a U-shaped function with the lowest threshold values at n-butanoic acid. A significant positive correlation between olfactory detection thresholds and carbon chain length of the carboxylic acids with their branching next to the functional carboxyl group was found. In contrast, no such correlation was found for carboxylic acids with their branching at the distal end of the carbon chain relative to the functional carboxyl group. Finally, a significant correlation was found between olfactory detection thresholds and the position of the branching of the carboxylic acids. Across-species comparisons suggest that mice are more sensitive for short-chained (C2 to C4) aliphatic n-carboxylic acids than other mammalian species, but not for longer-chained ones (C5 to C8). Further comparisons suggest that odor structure-activity relationships are both substance class- and species-specific.

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“…The sensitivity of the rodents to odors, i.e., the status of olfactory sensation, was evaluated by observing their initial response to odors at a minimal concentration [17], [18], [19]. This minimal concentration can be read out by stimulating animal olfaction with a specific odor in different concentrations.…”

Section: Resultsmentioning

confidence: 99%

The Functional Upregulation of Piriform Cortex Is Associated with Cross-Modal Plasticity in Loss of Whisker Tactile Inputs

et al. 2012

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BackgroundCross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain unclear. We aim to study the role of different types of neurons in cross-modal plasticity.Methodology/Principal FindingsIn addition to behavioral tasks in mice, whole-cell recordings at the excitatory and inhibitory neurons, and their two-photon imaging, were conducted in piriform cortex. We produced a mouse model of cross-modal sensory plasticity that olfactory function was upregulated by trimming whiskers to deprive their sensory inputs. In the meantime of olfactory hypersensitivity, pyramidal neurons and excitatory synapses were functionally upregulated, as well as GABAergic cells and inhibitory synapses were downregulated in piriform cortex from the mice of cross-modal sensory plasticity, compared with controls. A crosswire connection between barrel cortex and piriform cortex was established in cross-modal plasticity.Conclusion/SignificanceAn upregulation of pyramidal neurons and a downregulation of GABAergic neurons strengthen the activities of neuronal networks in piriform cortex, which may be responsible for olfactory hypersensitivity after a loss of whisker tactile input. This finding provides the clues for developing therapeutic strategies to promote sensory recovery and substitution.

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Type 4 phosphodiesterase inhibition impairs detection of low odor concentrations in mice

Cited by 18 publications

References 26 publications

Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

Olfactory Sensitivity and Odor Structure-Activity Relationships for Aliphatic Carboxylic Acids in CD-1 Mice

The Functional Upregulation of Piriform Cortex Is Associated with Cross-Modal Plasticity in Loss of Whisker Tactile Inputs

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