2016
DOI: 10.1523/eneuro.0257-16.2016
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Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

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Cited by 23 publications
(16 citation statements)
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References 74 publications
(99 reference statements)
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“…Serotonergic projections from the dorsal and medial raphe nucleus innervate the OB densely, where they may modulate the initial representation of olfactory information . Although elimination of most of the serotonergic neurons from the forebrain has no detectable effect on the ability of mice to perform a go/no‐go olfactory discrimination task, the activity of almost all neuron types in the OB is dramatically modulated by serotonin . Optogenetic activation of serotonergic neurons increases spontaneous firing in both mitral and tufted cells, and it also bidirectionally modulates odour‐evoked firing in MCs, resulting in improved pattern separation of odours .…”
Section: Feedback and Centrifugal Modulation Of The Obmentioning
confidence: 99%
“…Serotonergic projections from the dorsal and medial raphe nucleus innervate the OB densely, where they may modulate the initial representation of olfactory information . Although elimination of most of the serotonergic neurons from the forebrain has no detectable effect on the ability of mice to perform a go/no‐go olfactory discrimination task, the activity of almost all neuron types in the OB is dramatically modulated by serotonin . Optogenetic activation of serotonergic neurons increases spontaneous firing in both mitral and tufted cells, and it also bidirectionally modulates odour‐evoked firing in MCs, resulting in improved pattern separation of odours .…”
Section: Feedback and Centrifugal Modulation Of The Obmentioning
confidence: 99%
“…However, conditional depletion of 5-HT in the adult forebrain (including the OT) has no effect on odor discrimination or conditioned odor learning (Carlson, Whitney, Gadziola, Deneris, & Wesson, 2016). While a role for 5-HT in olfactory system development cannot be ruled out by this work, more research is needed to define the contributions of 5-HT release into the OT on olfaction.…”
Section: Widespread Serotonergic Innervation Of the Olfactory Systemmentioning
confidence: 81%
“…Widespread serotonergic innervation of the olfactory system suggests an important role for olfaction and odor‐guided behavior (McLean & Shipley, ; Petzold, Hagiwara, & Murthy, ). However, conditional depletion of 5‐HT in the adult forebrain (including the OT) has no effect on odor discrimination or conditioned odor learning (Carlson, Whitney, Gadziola, Deneris, & Wesson, ). While a role for 5‐HT in olfactory system development cannot be ruled out by this work, more research is needed to define the contributions of 5‐HT release into the OT on olfaction.…”
Section: Serotoninmentioning
confidence: 99%
“…However, studies directly manipulating serotonergic neurons or serotonergic signaling in the olfactory system indicate that the role of 5-HT is more complex. For instance, conditionally eliminating tryptophan hydroxylase 2 expression in the raphe of mice, and therefore 5-HT synthesis after olfactory development, had no effect on performance in several general olfactory behavioral assays (Carlson et al, 2016 ). In Drosophila , suppressing the activity of the serotonergic neurons in the AL (the “CSDns”) increases CO 2 avoidance, while blocking synaptic transmission decreases sensitivity to the pheromone cVA (Singh et al, 2013 ), suggesting that the effects of 5-HT can be odor dependent.…”
Section: Extrinsic Modulation Of Olfactory Processingmentioning
confidence: 99%