Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

Carlson, Kaitlin S.; Whitney, Marybeth; Gadziola, Marie A.; Deneris, Evan S.; Wesson, Daniel W.

doi:10.1523/eneuro.0257-16.2016

Cited by 25 publications

(17 citation statements)

References 74 publications

(99 reference statements)

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“…Serotonergic projections from the dorsal and medial raphe nucleus innervate the OB densely, where they may modulate the initial representation of olfactory information . Although elimination of most of the serotonergic neurons from the forebrain has no detectable effect on the ability of mice to perform a go/no‐go olfactory discrimination task, the activity of almost all neuron types in the OB is dramatically modulated by serotonin . Optogenetic activation of serotonergic neurons increases spontaneous firing in both mitral and tufted cells, and it also bidirectionally modulates odour‐evoked firing in MCs, resulting in improved pattern separation of odours .…”

Section: Feedback and Centrifugal Modulation Of The Obmentioning

confidence: 99%

Complex neural representation of odour information in the olfactory bulb

Rao

Zhou

et al. 2019

Acta Physiologica

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The most important task of the olfactory system is to generate a precise representation of odour information under different brain and behavioural states. As the first processing stage in the olfactory system and a crucial hub, the olfactory bulb plays a key role in the neural representation of odours, encoding odour identity, intensity and timing. Although the neural circuits and coding strategies used by the olfactory bulb for odour representation were initially identified in anaesthetized animals, a large number of recent studies focused on neural representation of odorants in the olfactory bulb in awake behaving animals. In this review, we discuss these recent findings, covering (a) the neural circuits for odour representation both within the olfactory bulb and the functional connections between the olfactory bulb and the higher order processing centres; (b) how related factors such as sniffing affect and shape the representation; (c) how the representation changes under different states;and (d) recent progress on the processing of temporal aspects of odour presentation in awake, behaving rodents. We highlight discussion of the current views and emerging proposals on the neural representation of odorants in the olfactory bulb. K E Y W O R D Sfeedback modulation, odour representation, olfactory bulb, physiological states, temporal information Anan Li and Diego Restrepo equally contributed to this work.

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Section: Feedback and Centrifugal Modulation Of The Obmentioning

confidence: 99%

Complex neural representation of odour information in the olfactory bulb

Rao

Zhou

et al. 2019

Acta Physiologica

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“…However, conditional depletion of 5-HT in the adult forebrain (including the OT) has no effect on odor discrimination or conditioned odor learning (Carlson, Whitney, Gadziola, Deneris, & Wesson, 2016). While a role for 5-HT in olfactory system development cannot be ruled out by this work, more research is needed to define the contributions of 5-HT release into the OT on olfaction.…”

Section: Widespread Serotonergic Innervation Of the Olfactory Systemmentioning

confidence: 81%

“…Widespread serotonergic innervation of the olfactory system suggests an important role for olfaction and odor‐guided behavior (McLean & Shipley, ; Petzold, Hagiwara, & Murthy, ). However, conditional depletion of 5‐HT in the adult forebrain (including the OT) has no effect on odor discrimination or conditioned odor learning (Carlson, Whitney, Gadziola, Deneris, & Wesson, ). While a role for 5‐HT in olfactory system development cannot be ruled out by this work, more research is needed to define the contributions of 5‐HT release into the OT on olfaction.…”

Section: Serotoninmentioning

confidence: 99%

Neurochemical organization of the ventral striatum’s olfactory tubercle

Cansler

Wright

Stetzik

et al. 2020

Journal of Neurochemistry

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The ventral striatum is a collection of brain structures, including the nucleus accumbens, ventral pallidum and the olfactory tubercle (OT). While much attention has been devoted to the nucleus accumbens, a comprehensive understanding of the ventral striatum and its contributions to neurological diseases requires an appreciation for the complex neurochemical makeup of the ventral striatum's other components. This review summarizes the rich neurochemical composition of the OT, including the neurotransmitters, neuromodulators and hormones present. We also address the receptors and transporters involved in each system as well as their putative functional roles. Finally, we end with briefly reviewing select literature regarding neurochemical changes in the OT in the context of neurological disorders, specifically neurodegenerative disorders. By overviewing the vast literature on the neurochemical composition of the OT, this review will serve to aid future research into the neurobiology of the ventral striatum.

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“…However, studies directly manipulating serotonergic neurons or serotonergic signaling in the olfactory system indicate that the role of 5-HT is more complex. For instance, conditionally eliminating tryptophan hydroxylase 2 expression in the raphe of mice, and therefore 5-HT synthesis after olfactory development, had no effect on performance in several general olfactory behavioral assays (Carlson et al, 2016 ). In Drosophila , suppressing the activity of the serotonergic neurons in the AL (the “CSDns”) increases CO 2 avoidance, while blocking synaptic transmission decreases sensitivity to the pheromone cVA (Singh et al, 2013 ), suggesting that the effects of 5-HT can be odor dependent.…”

Section: Extrinsic Modulation Of Olfactory Processingmentioning

confidence: 99%

Intrinsic and Extrinsic Neuromodulation of Olfactory Processing

Lizbinski

Dacks

2018

Front. Cell. Neurosci.

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Neuromodulation is a ubiquitous feature of neural systems, allowing flexible, context specific control over network dynamics. Neuromodulation was first described in invertebrate motor systems and early work established a basic dichotomy for neuromodulation as having either an intrinsic origin (i.e., neurons that participate in network coding) or an extrinsic origin (i.e., neurons from independent networks). In this conceptual dichotomy, intrinsic sources of neuromodulation provide a “memory” by adjusting network dynamics based upon previous and ongoing activation of the network itself, while extrinsic neuromodulators provide the context of ongoing activity of other neural networks. Although this dichotomy has been thoroughly considered in motor systems, it has received far less attention in sensory systems. In this review, we discuss intrinsic and extrinsic modulation in the context of olfactory processing in invertebrate and vertebrate model systems. We begin by discussing presynaptic modulation of olfactory sensory neurons by local interneurons (LNs) as a mechanism for gain control based on ongoing network activation. We then discuss the cell-class specific effects of serotonergic centrifugal neurons on olfactory processing. Finally, we briefly discuss the integration of intrinsic and extrinsic neuromodulation (metamodulation) as an effective mechanism for exerting global control over olfactory network dynamics. The heterogeneous nature of neuromodulation is a recurring theme throughout this review as the effects of both intrinsic and extrinsic modulation are generally non-uniform.

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Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis

Abstract: Visual Abstract

Cited by 25 publications

References 74 publications

Complex neural representation of odour information in the olfactory bulb

Complex neural representation of odour information in the olfactory bulb

Neurochemical organization of the ventral striatum’s olfactory tubercle

Intrinsic and Extrinsic Neuromodulation of Olfactory Processing

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