Type 2 diabetes mellitus predicts cognitive decline: Evidence from the Irish longitudinal study on ageing (TILDA)

Cominetti, Márcia Regina; Pott-Júnior, Henrique; Cominetti, Cristiane; Gutiérrez-Zúñiga, Raquel; Romero-Ortuño, Román

doi:10.1016/j.deman.2022.100087

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…The initial evaluations showed a decrease in MMSE and MoCA values related to age, male sex, as well as the presence of DM-2, SH, and stroke. After 6 years of follow-up, MMSE changes were greater in patients with DM-2, indicating an increased risk for CD [ 44 ]. Similarly, another study that compared 100 diabetic patients with 100 non-DM-2 controls, highlighted significantly lower MoCA scores among the first group ( p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2

Militaru,

Lighezan,

Tudoran

et al. 2024

Biomedicines

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(1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have a higher prevalence in those with associated atrial fibrillation (AF). In this study, we aimed to research if the association of DM-2 and AF favors a precocious onset of CD. (2) Methods: This study was conducted on 160 patients, featuring 50 with DM-2, 54 with DM-2 and AF, and 56 subjects without DM-2 and AF, all evaluated clinically and with five neuropsychiatric scales. (3) Results: The Mini-Mental-State-Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living Score (ADL), Instrumental Activities of Daily Living Score (IADL), and Geriatric Depression Scale (GDS-15) were significantly altered in patients with DM-2 and AF in comparison to patients without these diseases. The logistic regression model indicated that, in patients with DM-2 and AF, an increase of one year in age is associated with a 7.3% augmentation of the risk of a precocious onset of CD (MMSE < 27). (4) Conclusions: CD is more frequent in patients with DM-2, especially when associated with AF, versus those without DM-2 and AF. Our findings suggest that an older age and associated dyslipidemia represent risk factors for CD in patients with DM-2.

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Section: Discussionmentioning

confidence: 99%

Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2

Militaru,

Lighezan,

Tudoran

et al. 2024

Biomedicines

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“…Age, male sex, stroke, and hypertension were significantly associated with a higher number of errors in the MMSE score at baseline. Over six years, DM was significantly associated with an accelerated decline in cognition [33].…”

Section: Absence Of Dementiamentioning

confidence: 98%

Correlations between Cognitive Evaluation and Metabolic Syndrome

2023

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One of the most common medical diseases is metabolic syndrome (MetS), which encompasses diabetes and obesity. It has a systemic effect, which has long-lasting consequences on the body that are still not fully understood. The objectives of the study were to investigate the association between the severity of metabolic imbalances, insulin resistance, leptin concentration, and the presence of cognitive disorders and to assess the possible protective role of some classes of drugs used in the treatment of type 2 diabetes mellitus (T2D) and dyslipidemia in order to identify a viable target in the near future. The study included 148 diabetic patients. Standardized tests for the evaluation of cognition, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), were applied to all study participants. Serum concentrations of leptin and insulin were determined using the enzyme-linked immunosorbent assay method (ELISA), and insulin resistance was calculated using the homeostatic model assessment for insulin resistance (HOMA-IR). We found that MMSE and MoCA scores were associated with anthropometric parameters, and MoCA was associated with glycemic control parameters and leptin levels. Further research is needed in order to establish the magnitude of the relationship between metabolic syndrome components and cognitive decline in diabetic patients.

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Nativity differences in the relationship between handgrip strength and cognitive impairment in older Mexican Americans over 20 years of follow-up

Ventura¹,

Downer

et al. 2023

Archives of Gerontology and Geriatrics

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Type 2 diabetes mellitus predicts cognitive decline: Evidence from the Irish longitudinal study on ageing (TILDA)

Cited by 4 publications

References 39 publications

Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2

Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2

Correlations between Cognitive Evaluation and Metabolic Syndrome

Nativity differences in the relationship between handgrip strength and cognitive impairment in older Mexican Americans over 20 years of follow-up

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