Correlations between Cognitive Evaluation and Metabolic Syndrome

Oprescu, A.C.; Grosu, Cristina; Bild, Walther

doi:10.3390/metabo13040570

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…For the diagnosis of mild cognitive impairment (MCI), the MCI Working Group of the European Consortium on Alzheimer's Disease, Brescia Meeting, Italy, June 2005 Criteria are used (see Table 1) [96,97].…”

Section: Consequences Observed On Obese Patients From a Neurological ...mentioning

confidence: 99%

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Inflammatory Pathways in Overweight and Obese Persons as a Potential Mechanism for Cognitive Impairment and Earlier Onset Alzeihmer’s Dementia in the General Population: A Narrative Review

Costache,

Ignat,

Grosu

et al. 2023

Biomedicines

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The overweight status or obesity can be confirmed through classical methods such as the body mass index (BMI) and the waist-to-hip ratio (WHR). Apart from metabolic issues such as atherosclerosis, liver steatosis, or diabetes mellitus, long-term obesity or overweight status can pose a risk for cardiovascular and neurovascular complications. While some acute adverse events like coronary syndromes of strokes are well-documented to be linked to an increased body mass, there are also chronic processes that, due to their silent onset and evolution, are underdiagnosed and not as thoroughly studied. Through this review, we aimed to collect all relevant data with regard to the long-term impact of obesity on cognitive function in all ages and its correlation with an earlier onset of dementia such as Alzheimer’s disease (AD). The exact mechanisms through which a decline in cognitive functions occurs in overweight or obese persons are still being discussed. A combination of factors has been acknowledged as potential triggers, such as a sedentary lifestyle and stress, as well as a genetic predisposition, for example, the apolipoprotein E (ApoE) alleles in AD. Most research highlights the impact of vascular dysfunction and systemic inflammation on the nervous system in patients with obesity and the subsequent neurological changes. Obesity during the early to mid-ages leads to an earlier onset of cognitive dysfunction in various forms. Also, lifestyle intervention can reverse cognitive dysfunction, especially dieting, to encourage weight loss.

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Section: Consequences Observed On Obese Patients From a Neurological ...mentioning

confidence: 99%

“…Cognitive impairment reported by patients or their families [96,97] Reported decline in cognitive functioning relative to previous abilities during the past year by the patient or informant…”

Section: Criteria Referencesmentioning

confidence: 99%

Inflammatory Pathways in Overweight and Obese Persons as a Potential Mechanism for Cognitive Impairment and Earlier Onset Alzeihmer’s Dementia in the General Population: A Narrative Review

Costache,

Ignat,

Grosu

et al. 2023

Biomedicines

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Nicht medikamentöse Prophylaxe und Therapie der Demenz durch Bewegung und Sport

Maschke

2024

Nervenheilkunde

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ZUSAMMENFASSUNGVor dem Hintergrund der Zunahme demenzieller Erkrankungen sind nicht medikamentöse Therapiemaßnahmen zur Verminderung der Neuerkrankungsrate an Demenz und zur Behandlung demenzerkrankter Patienten überaus wichtig. Bewegung und Sport zählen zu den am besten bewiesenen Maßnahmen. Freiwillige physische Aktivität führt tierexperimentell zu einer Verminderung von ß-Amyloid-Plaques und Erhöhung von neurotrophen Faktoren wie BDNF. Multimodale Interventionsstudien zeigten in größeren Studien einen Effekt auf die Kognition gesunder älterer Menschen oder bei Patienten mit gering ausgeprägter Demenz. Welche genauen Bewegungsübungen jedoch am wirksamsten sind, muss in Studien noch geklärt werden.

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Correlations between Cognitive Evaluation and Metabolic Syndrome

Cited by 2 publications

References 39 publications

Inflammatory Pathways in Overweight and Obese Persons as a Potential Mechanism for Cognitive Impairment and Earlier Onset Alzeihmer’s Dementia in the General Population: A Narrative Review

Inflammatory Pathways in Overweight and Obese Persons as a Potential Mechanism for Cognitive Impairment and Earlier Onset Alzeihmer’s Dementia in the General Population: A Narrative Review

Nicht medikamentöse Prophylaxe und Therapie der Demenz durch Bewegung und Sport

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