Type 2 Diabetes Mellitus Is Associated With Increased Mortality in Chinese Patients Receiving Curative Surgery for Colon Cancer

Abstract

Background. We investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery. Methods. From three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage II colon cancer between January 1, 2004 and December 31, 2008 and had undergone curative surgery. We collected information regarding DM (type 2 DM only), the use of antidiabetic medications, other comorbidities, and survival outcomes. The colon cancer-specific survival (CSS) and the overall survival (OS) were compared between patients with and without DM. Results. We selected 6,937 colon cancer patients, among whom 1,371 (19.8%) had DM. The colon cancer patients with DM were older and less likely to receive adjuvant

Association between metformin use after surgery for colorectal cancer and oncological outcomes: A nationwide register‐based study

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“…Diabetes mellitus and colorectal cancer share several risk factors including obesity and physical inactivity, and diabetes is proven to be an independent risk factor for developing colorectal cancer . Several studies have shown that patients with both colorectal cancer and diabetes have a lower survival compared to patients without diabetes, whereas other studies have reported no association . Metformin is the drug of choice for treatment of type 2 diabetes.…”

The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies

“…In our meta-analysis, year of publication ranged from 2003 to 2016, and the regions included 2 American countries[7, 13–15, 18, 19, 27, 30, 33, 37, 41, 42, 45, 46], 6 European countries[6, 11, 17, 28, 32, 39, 40, 44], 2 Asian countries[8, 9, 12, 16, 20, 29, 34–36, 38, 43, 47] and 1 Oceania country[31]; the included studies contained 15 retrospective[9, 10, 14, 16–20, 27, 33, 36, 37, 39, 41, 47] and 21 prospective[6–8, 11–13, 15, 28–32, 34, 35, 38, 40, 42–46] cohort studies; the sample size ranged from 391 to 1056243, and the mean age of study ranged from 46.4 to 72.07. In DM ascertainment, 25 studies[6, 8, 9, 11–15, 18, 19, …”

Diabetes and Body Mass Index Are Associated with Neuropathy and Prognosis in Colon Cancer Patients Treated with Capecitabine and Oxaliplatin Adjuvant Chemotherapy

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