Type 2 diabetes is associated with postprandial amino acid measures

Mook‐Kanamori, Dennis O.; Mutsert, Renée de; Rensen, Patrick C.N.; Prehn, Cornelia; Adamski, Jerzy; Heijer, Martin den; Cessie, Saskia le; Suhre, Karsten; Rosendaal, Frits R.; Dijk, Ko Willems van

doi:10.1016/j.abb.2015.08.003

Cited by 32 publications

(19 citation statements)

References 27 publications

(48 reference statements)

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“…Similar studies of patients with type 2 diabetes have found reduced L‐serine concentration in blood . The postprandial L‐serine concentration in response to a standardized meal differs between type 2 diabetes patients and non‐diabetic controls, with patients having a reduced concentration of L‐serine in blood, while controls have an increased concentration . Finally, then two studies have reported conflicting results showing a decreased or increased concentration of L‐serine in the blood of individuals with gestational diabetes .…”

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confidence: 91%

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

Holm

Buschard

2019

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L‐serine is classified as a non‐essential amino acid; however, L‐serine is indispensable having a central role in a broad range of cellular processes. Growing evidence suggests a role for L‐serine in the development of diabetes mellitus and its related complications, with L‐serine being positively correlated to insulin secretion and sensitivity. L‐serine metabolism is altered in type 1, type 2, and gestational diabetes, and L‐serine supplementations improve glucose homeostasis and mitochondrial function, and reduce neuronal death. Additionally, L‐serine lowers the incidence of autoimmune diabetes in NOD mice. Dietary supplementations of L‐serine are generally regarded as safe (GRAS) by the FDA. Therefore, we believe that L‐serine should be considered as an emerging therapeutic option in diabetes, although work remains in order to fully understand the role of L‐serine in diabetes.

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confidence: 91%

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

Holm

Buschard

2019

APMIS

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“…The plasma profile of amino acids in relation to the risk of diabetes has been investigated in several previous studies [ 11 , 12 , 13 ]. However the possible role of dietary amino acid intakes in the development of dysglycemia and insulin resistance remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Dietary Protein and Amino Acid Profiles in Relation to Risk of Dysglycemia: Findings from a Prospective Population-Based Study

et al. 2017

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Considering the limited knowledge on the effects of dietary amino acid intake on dysglycemia, we assessed the possible association of dietary protein and amino acid patterns with the risk of pre-diabetes in a prospective population-based study. Participants without diabetes and pre-diabetes (n = 1878) were recruited from the Tehran Lipid and Glucose Study and were followed for a mean of 5.8 years. Their dietary protein and amino acid intakes were assessed at baseline (2006–2008); demographic, lifestyle, and biochemical variables were evaluated at baseline and in follow-up examinations. Pre-diabetes was defined according to the American Diabetes Association criteria. Multivariate Cox proportional hazard regression models, adjusted for potential confounders, were used to estimate the risk of pre-diabetes across tertiles of dietary protein and amino acid pattern scores. The mean age of the participants (44.9% men) was 38.3 ± 12.7 years at baseline. Three major amino acid patterns were characterized: (1) higher loads of lysine, methionine, valine, aspartic acids, tyrosine, threonine, isoleucine, leucine, alanine, histidine, and serine; (2) higher loads of glycine, cysteine, arginine, and tryptophan; and (3) higher loads of proline and glutamic acid. Dietary total protein intake Hazard Ratio (HR) = 1.13, 95% Confidence Interval (CI) = 0.92–1.38 and HR = 1.00, 95% CI = 0.81–1.23, in the second and third tertile, respectively) was not related to the development of pre-diabetes. The highest score of second dietary amino acid pattern tended to be associated with a decreased risk of pre-diabetes (HR = 0.81, 95% CI = 0.65–1.01), whereas the third pattern was related to an increased risk in the fully adjusted model (HR = 1.24, 95% CI = 1.02–1.52; p for trend = 0.05). These novel data suggest that the amino acid composition of an individual’s diet may modify their risk of pre-diabetes.

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“…A decrease in plasma leucine concentrations after a glucose challenge has been reported in healthy adults [35]. In contrast, increased concentrations of (iso)leucine have been reported after a glucose challenge and standardised meal challenge in individuals with insulin resistance and in patients with type 2 diabetes [33,36]. Furthermore, it was recently reported that pregnant women with high fasting plasma glucose concentrations also had high fasting concentrations of several amino acids, including leucine [37].…”

Section: Discussionmentioning

confidence: 99%

“…Glycerophospholipid and BCAA levels are reported to be related to insulin resistance, type 2 diabetes and obesity [29][30][31][32][33]. Moreover, population-based studies of previously healthy adults revealed that low lyso-PC C18:2 concentrations were associated with an increased risk of pre-type 2 diabetes and type 2 diabetes [30,34], while high concentrations of several diacyl-PCs (C32:1, C36:1, C38:3 and C40:5) were associated with a risk of type 2 diabetes independent of dietary, lifestyle and anthropometric factors.…”

Section: Discussionmentioning

confidence: 99%

Lactation is associated with altered metabolomic signatures in women with gestational diabetes

et al. 2016

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Aims/hypothesis Lactation for >3 months in women with gestational diabetes is associated with a reduced risk of type 2 diabetes that persists for up to 15 years postpartum. However, the underlying mechanisms are unknown. We examined whether in women with gestational diabetes lactation for >3 months is associated with altered metabolomic signatures postpartum. Methods We enrolled 197 women with gestational diabetes at a median of 3.6 years (interquartile range 0.7-6.5 years) after delivery. Targeted metabolomics profiles (including 156 metabolites) were obtained during a glucose challenge test. Comparisons of metabolite concentrations and ratios between women who lactated for >3 months and women who lactated for ≤3 months or not at all were performed using linear regression with adjustment for age and BMI at the postpartum visit, time since delivery, and maternal education level, and correction for multiple testing. Gaussian graphical modelling was used to generate metabolite networks.Results Lactation for >3 months was associated with a higher total lysophosphatidylcholine/total phosphatidylcholine ratio; in women with short-term follow-up, it was also associated with lower leucine concentrations and a lower total branchedchain amino acid concentration. Gaussian graphical modelling identified subgroups of closely linked metabolites within phosphatidylcholines and branched-chain amino acids that were affected by lactation for >3 months and have been linked to the pathophysiology of type 2 diabetes in previous studies. Conclusions/interpretation Lactation for >3 months in women with gestational diabetes is associated with changes in the metabolomics profile that have been linked to the early pathogenesis of type 2 diabetes.

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Type 2 diabetes is associated with postprandial amino acid measures

Cited by 32 publications

References 27 publications

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

L‐serine: a neglected amino acid with a potential therapeutic role in diabetes

Dietary Protein and Amino Acid Profiles in Relation to Risk of Dysglycemia: Findings from a Prospective Population-Based Study

Lactation is associated with altered metabolomic signatures in women with gestational diabetes

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