Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection

Norouzi, Maryam; Norouzi, Shaghayegh; Ruggiero, Alistaire; Khan, Mohammad Sharif; Myers, Stephen; Kavanagh, Kylie; Vemuri, Ravichandra

doi:10.3390/microorganisms9061211

Cited by 47 publications

(52 citation statements)

References 105 publications

(189 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, TKT activity is enhanced in diabetes patients [ 19 , 20 , 21 ] and diabetes patients are at a high risk from COVID-19 [ 4 , 5 , 6 ]. Given the potential role of TKT in SARS-CoV-2 replication identified here, elevated TKT levels may be one of the factors that predispose diabetes patients to experience severe COVID-19.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy

et al. 2021

View full text Add to dashboard Cite

SARS-CoV-2 is causing the coronavirus disease 2019 (COVID-19) pandemic, for which effective pharmacological therapies are needed. SARS-CoV-2 induces a shift of the host cell metabolism towards glycolysis, and the glycolysis inhibitor 2-deoxy-d-glucose (2DG), which interferes with SARS-CoV-2 infection, is under development for the treatment of COVID-19 patients. The glycolytic pathway generates intermediates that supply the non-oxidative branch of the pentose phosphate pathway (PPP). In this study, the analysis of proteomics data indicated increased transketolase (TKT) levels in SARS-CoV-2-infected cells, suggesting that a role is played by the non-oxidative PPP. In agreement, the TKT inhibitor benfooxythiamine (BOT) inhibited SARS-CoV-2 replication and increased the anti-SARS-CoV-2 activity of 2DG. In conclusion, SARS-CoV-2 infection is associated with changes in the regulation of the PPP. The TKT inhibitor BOT inhibited SARS-CoV-2 replication and increased the activity of the glycolysis inhibitor 2DG. Notably, metabolic drugs like BOT and 2DG may also interfere with COVID-19-associated immunopathology by modifying the metabolism of immune cells in addition to inhibiting SARS-CoV-2 replication. Hence, they may improve COVID-19 therapy outcomes by exerting antiviral and immunomodulatory effects.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Metabolic disorders and diabetes are associated with an increased risk of severe COVID-19 [ 4 , 5 , 6 ]. Increased amounts of glucose in the sera of COVID-19 patients were correlated with poor prognosis in individuals both with and without pre-existing diabetes [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In turn, the increased glucose metabolism imposed by sustained hyperglycemia seems to enhance SARS-CoV-2's entry and subsequent replication, as well as exacerbated immune responses such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. [21][22] Thus, a disrupted glucose metabolism and metabolic derangement may be an intrinsic cellular strategy that favors SARS-CoV-2 pathogenesis. [22] Therefore, hyperglycemia may not only be a result of in vivo reactions, but it may also be involved in the enhancement of immune responses and excessive immune responses, such as those seen in COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Combining Blood Glucose and SpO 2 /FiO 2 Ratio Facilitates Prediction of Imminent Ventilatory Needs in Emergency Room COVID-19 patients

Sakai

Okoda

Nishii

et al. 2021

Preprint

View full text Add to dashboard Cite

The increasing requirement of mechanical ventilation (MV) due to the novel coronavirus disease (COVID-19) is still a global threat. The aim of this study is to identify markers that can easily stratify the impending use of MV in the emergency room (ER). A total of 106 patients with COVID-19 requiring oxygen support were enrolled. Fifty-nine patients were provided MV 0.5 hours (interquartile range: 0.3 to 1.4) post-admission. Clinical and laboratory data before intubation were collected. Using a multivariate logistic regression model, we identified four markers associated with the impending use of MV, including the ratio of peripheral blood oxygen saturation to fraction of inspired oxygen (SpO2/FiO2 ratio), alanine aminotransferase, blood glucose (BG), and lymphocyte counts. Among these markers, the combination of SpO2/FiO2 ratio and BG, which can be measured easily and immediately, showed higher accuracy in its prediction (AUC: 0.88) compared to SpO2/FiO2 ratio alone (AUC: 0.84). Moreover, even in patients without severe respiratory failure (SpO2/FiO2 ratio > 300), BG (> 138 mg/dL) was predictive of MV use. Measuring BG and SpO2/FiO2 ratio may be a simple and versatile new strategy to accurately identify ER patients with COVID-19 at high risk for the imminent need of MV.

show abstract

“…Selain itu, pada pasien diabetes secara signifikan mengalami pneumonia bilateral yang lebih tinggi dibandingkan dengan pasien non diabetes, proporsi komplikasi yang lebih tinggi, termasuk gagal napas dan cedera jantung akut, serta tingkat kematian yang lebih tinggi. Hasil penelitian ini berkorelasi dengan temuan sebelumnya yang melaporkan bahwa peningkatan protein C-reaktif (CRP), fibrinogen, dan Ddimer pada penderita diabetes melitus dapat menyebabkan keadaan hiperkoagulasi pada pasien Covid-19 (Norouzi et al, 2021).…”

Section: Pembahasanunclassified

Faktor Risiko Terjadinya Covid-19 Pada Penderita Diabetes Melitus Tipe 2

Panua¹,

Zainuddin²,

Ahmad³

et al. 2021

fulltext PDF

View full text Add to dashboard Cite

Pendahuluan: Covid-19 merupakan penyakit menular yang muncul pertama kali di kota Wuhan China dan disebabkan oleh SARS-CoV-2. Tujuan mengidentifikasi faktor risiko terjadinya Covid-19 pada penderita DM tipe 2. Metode: Deskriptif analitis desain literature review. Data diperoleh melalui hasil pencarian artikel menggunakan lima database eletronik yaitu Pubmed, ProQuest, ScienceDirect, Cochrane Library dan Google Scholar diidentifikasi 10.951 artikel dengan jumlah sampel keseluruhan 5.464.617 responden. Analisis menggunakan peta data yang diekstraksi dalam tabel sintesis grid termasuk penulis, tahun publikasi, negara, tujuan, sampel, desain, durasi, hasil dan kesimpulan penelitian. Hasil: Enam artikel teridentifikasi dalam tinjauan ini menunjukkan bahwa, satu studi melaporlakan risiko terjadinya Covid-19 pada penderita DM tipe 2 sebesar 1.369 kali, satu studi 2,180 kali, satu studi 4.7 kali, dan satu studi lainnya hingga16.5 kali. Pasien yang berjenis kelamin laki-laki dan berusia ≥53 tahun memiliki risiko sebesar 1,395 kali lebih tinggi dibandingkan dengan orang yang berusia lebih muda dan berjenis kelamin perempuan. Kesimpulan: bahwa penderita DM tipe 2 secara signifikan memiliki risiko lebih tinggi terkena Covid-19 dibandingkan dengan orang yang tidak memiliki penyakit diabetes, terutama pada pasien yang berusia ≥53 tahun dan berjenis kelamin laki-laki.

show abstract

Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection

Cited by 47 publications

References 105 publications

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy

Combining Blood Glucose and SpO 2 /FiO 2 Ratio Facilitates Prediction of Imminent Ventilatory Needs in Emergency Room COVID-19 patients

Faktor Risiko Terjadinya Covid-19 Pada Penderita Diabetes Melitus Tipe 2

Contact Info

Product

Resources

About