Type 2 diabetes and metabolic syndrome – adipokine levels and effect of drugs

Farooq, Rabia; Amin, Shajrul; Bhat, Mohd Shafi; Malik, Rawoof Ahmad; Wani, Hilal Ahmad; Majid, Sabhiya

doi:10.1080/09513590.2016.1207165

Cited by 19 publications

(13 citation statements)

References 27 publications

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“…In addition, surgical stress has a greater impact on serum adiponectin and resistin levels than stress from fasting. In type 2 DM patients, plasma adiponectin levels were lower and plasma resistin levels were higher than normal patients [15,16]. This means that changes in plasma adipocytokine levels influence plasma glucose levels, and that the regulation of plasma glucose in DM patients differs from normal patients.…”

Section: Discussionmentioning

confidence: 82%

Changes of Plasma Levels of Adipocytokines During 120 Hours of Fasting After Endoscopic Treatment

Maekawa¹,

Shioya²,

Orita³

et al. 2017

J Nutr Disorders Ther

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Study background: Adipocytokines are secreted from adipocytes and are important for metabolic regulation and immune response. We investigated differences in plasma adipocytokine levels between diabetes mellitus patients and non-diabetes mellitus patients during 120 hours of fasting after endoscopic treatment. We also compared changes in plasma adipocytokine levels from minimally invasive endoscopically-treated patients to those of patients treated with pancreatoduodenectomy. Materials and Methods:Seven diabetes mellitus patients, nine non-diabetes mellitus patients, and six patients who underwent pancreatoduodenectomy were analyzed for their WBC counts, plasma levels of CRP, glucose, adiponectin, adipsin, resistin and IL-6 levels at four points. Blood samples were drawn at pre-treatment, 24 hours of fasting, 72 hours of fasting, and 120 hours of fasting after treatment. Adipocytokines were examined using an ELISA method.Results: Plasma adiponectin levels slightly decreased during the fast, and resistin levels transiently increased at the 24-hour time point in both diabetes mellitus patients and non-diabetes mellitus patients. Plasma adipsin levels were stable. In patients who underwent pancreatoduodenectomy, both a decrease and increase of adipocytokine plasma levels occurred. There was a significant percentage decrease of plasma adiponectin and adipsin levels during the fast in patients who underwent pancreatoduodenectomy compared to those of endoscopically treated patients. In pancreatoduodenectomy patients, plasma resistin, IL-6 levels were significantly increased compared to those of endoscopically treated patients after treatment.Conclusions: Prolonged fasting after endoscopic treatment did not influence plasma adiponectin, adipsin, and resistin levels both for diabetes mellitus patients and non-diabetes mellitus patients. The decrease of plasma adiponectin and adipsin levels, and the increase of plasma resistin and IL-6 levels were significant in patients who underwent pancreatoduodenectomy. Surgical stress may influence plasma adipocytokine levels, but 120 hours of fasting with minimal invasive stress, such as endoscopic treatment, may have no effect.

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Section: Discussionmentioning

confidence: 82%

Changes of Plasma Levels of Adipocytokines During 120 Hours of Fasting After Endoscopic Treatment

Maekawa¹,

Shioya²,

Orita³

et al. 2017

J Nutr Disorders Ther

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“…25 In this study, patients with DM2 were treated with antidiabetic drugs including sulfonylureas and DPP-4 inhibitors until 1 day before surgery. Because these antidiabetic drugs are reported to elevate plasma adiponectin concentration, [26][27][28] metabolic variables such as adiponectin, leptin, blood glucose and HbA1c were not measured in the present study. Therefore, an influence of reduced H3K9 acetylation at the promoter regions of Dbp in visceral adipose tissue on glucose metabolism could not be evaluated.…”

Section: Discussionmentioning

confidence: 99%

Expression of clock geneDbpin omental and mesenteric adipose tissue in patients with type 2 diabetes

Ushijima

Suzuki

Kitamura

et al. 2020

BMJ Open Diab Res Care

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IntroductionWe previously reported in ob/ob mice, one of animal models of human type 2 diabetes mellitus (DM2), that (i) acetylation of histone H3 lysine 9 (H3K9) at the promoter region of clock gene Dbp and DBP mRNA expression are reduced in epididymal adipose tissue, (ii) binding of DBP to the promoter region of peroxisome proliferator-activated receptor (Ppar)-γ and mRNA expression of PPAR-γ1sv were decreased in preadipocytes and (iii) adiponectin secretion was decreased, leading to the impaired insulin sensitivity.Research design and methodsThe present study was undertaken to evaluate whether such the changes in visceral adipose tissue were detected in patients with DM2. We obtained omental and mesenteric adipose tissue during surgery of lymph node dissection for gastric and colorectal cancers, and investigated these variables in adipose tissue (omental from gastric cancer; 13 non-DM, 12 DM2: mesenteric from colorectal cancer; 12 non-DM, 11 DM2).ResultsAcetylation of histone H3K9 at the promoter region of Dbp and DBP mRNA expression in omental, but not in mesenteric adipose tissue were significantly lower in DM2 than in patients without DM. PPAR-γ mRNA expression in omental adipose tissue was also lower in patients with DM2, but not in mesenteric adipose tissue.ConclusionsThe changes in DBP-PPAR-γ axis observed in mice with diabetes were also detected in patients with DM2. Because adiponectin secretion is reported to be enhanced through the PPAR-γ-related mechanism, this study supports the hypothesis that omental adipose tissue is involved in the mechanism of DM2.

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“…It shows that the adipokine levels are not affected by diabetes only, suggesting that their alterations in T2DM may be due to obesity. Therefore, there might be important links between adiposity and insulin resistance [29].…”

Section: Discussionmentioning

confidence: 99%

Serum resistin and adiponectin relationships with glucometabolic control in patients with type 2 diabetes mellitus

Al-Regaiey

Habib

et al. 2018

Srp Arh Celok Lek

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Introduction/Objective Adiponectin and resistin are important adipokines that play an important role in the regulation of blood sugar, beta-oxidation in muscles, and insulin resistance. This study aimed to assess and compare the relationships of resistin and adiponectin concentrations with glucometabolic control in patients with type 2 diabetes mellitus (T2DM). Methods A total of 191 subjects were studied. The final selection included 107 patients with T2DM (67 males and 40 females) and 84 healthy control subjects (45 males and 39 females). Fasting venous blood samples were analyzed for glucose (FBG), glycosylated hemoglobin (HbA1c), insulin, lipids, adiponectin and resistin levels. Body composition was evaluated in all subjects by the body mass index (BMI) and waist-hip ratio (WHR). Results BMI, WHR, FBG, HbA1c, homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol, and triglycerides were significantly higher in individuals with T2DM compared to healthy volunteers. Serum resistin levels were significantly higher (p = 0.0259) and serum adiponectin levels were significantly lower (p = 0.0001) in T2DM patients than in control subjects. Adiponectin levels were significantly lower (p = 0.0411) in diabetes patients with poor glycemic control, compared to those with good glycemic control, while the difference was non-significant for resistin (p = 0.8899). Serum adiponectin levels were discordant with HbA1c (r =-0.274, p = 0.004). Linear-by-linear association showed significant trend of better glycemic control at increasing quartiles of adiponectin levels (p = 0.042), while the trend was not significant for resistin levels (p = 0.904). Multiple regression analysis revealed FBG, insulin, HOMA-IR, and HbA1c as significant predictors of adiponectin. Conclusions T2DM patients have significantly higher resistin and lower adiponectin levels compared to healthy controls. Adiponectin levels were significantly lower in patients with poor glycemic control.

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Type 2 diabetes and metabolic syndrome – adipokine levels and effect of drugs

Cited by 19 publications

References 27 publications

Changes of Plasma Levels of Adipocytokines During 120 Hours of Fasting After Endoscopic Treatment

Changes of Plasma Levels of Adipocytokines During 120 Hours of Fasting After Endoscopic Treatment

Expression of clock geneDbpin omental and mesenteric adipose tissue in patients with type 2 diabetes

Serum resistin and adiponectin relationships with glucometabolic control in patients with type 2 diabetes mellitus

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