Type 1 diabetic children have abnormal lipid profiles during pubertal years 1

Polak, Michel; Souchon, Pierre‐François; Bénali, Karim; Tubiana‐Rufi, N.; Czernichow, P

doi:10.1034/j.1399-5448.2000.010204.x

Cited by 23 publications

(32 citation statements)

References 14 publications

(16 reference statements)

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“…The increased prevalence of DLP has previously been reported, even among young patients (1-3,14). However, the prevalence in the present study was much higher than that found by Polak and cols., who reported that 16% of puberal patients with T1D had elevated TC, while 5% had hypertriglyceridemia (15). Regarding the atherogenic profile, the most commonly reported forms of DLP in patients with T1D include elevated TC, LDL, and TG values (4,6,9) which are similar to the findings observed in the present study.…”

Section: Discussionsupporting

confidence: 89%

Dyslipidemia in young patients with type 1 diabetes mellitus

Homma

Endo

Saruhashi

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The association between type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increases the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the presence of dyslipidemia in young T1D patients. Materials and methods: The study design was cross-sectional and descriptive. We reviewed medical records of T1D patients followed at an endocrinology service, from 1998-2012. Data collected: gender, actual age and age at diagnosis, duration of T1D since diagnosis, body mass index (BMI), pubertal stage, glycemic control (GC) determined by glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL, triglycerides (TG). To analyze lipid profile and metabolic control, we used the Brazilian Society of Diabetes Guidelines. Results: Were included 239 T1D patients, 136 (56.9%) females; mean ± SD: actual age 15.7 ± 5.0 years and at T1D diagnosis 7.3 ± 3.9; T1D duration 10.6 ± 6.4 years, 86.6% puberty, 15.1% overweight. The prevalence of DLP was 72.5%, 63.3% females, 86.6% puberty, mean ± SD: actual age 15.4 ± 4.8 years and at T1D diagnosis 7.2 ± 4.1 years, duration of T1D 10.7 ± 6.1 years. We found high-CT in 56.7%, low-HDL = 21.7%, high LDL = 44.0%, high-TG = 11.8%. Between females with DLP, 83.5% was in puberty. We find correlation between the presence of DLP, a poor GC and BMC. Conclusion: We found a high prevalence of DLP in young patients with T1D, particularly in puberty females. Programs targeting the prevention of dyslipidemia should be adopted, especially for this group, in order to prevent/delay chronic complications and cardiovascular disease. Arch Endocrinol Metab. 2015;59(3):215-9

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Section: Discussionsupporting

confidence: 89%

Dyslipidemia in young patients with type 1 diabetes mellitus

Homma

Endo

Saruhashi

et al. 2015

Arch. Endocrinol. Metab.

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“…also found that dyslipidemia was more common in adolescents than younger children (15), what would be expected based on previous studies (17,18). Females were particularly affected.…”

supporting

confidence: 77%

“…Overweight and obesity were associated with dyslipidemia and total hypercholesterolemia was the most common abnormality. This proportion was higher than that found in other studies (16)(17)(18), even in our population (16). It is probable that the higher rates of dyslipidemia in this study are explained by the higher HbA1c levels presented by this sample, although information about TSH levels and proportion of statin users are lacking in the paper and would be important to interpret these data.…”

contrasting

confidence: 75%

Obesity and dyslipidemia – An urgent matter in youth from the general population and in type 1 diabetic patients

Rodacki

2015

Arch. Endocrinol. Metab.

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“…Dyslipidemia frequency in diabetic children varies between 3.8% and 72.5% in different studies [14][15][16][17][18][19], and hypercholesterolemia was reported as the most frequent finding [16,[19][20][21]. Redondo et al found a dyslipidemia prevalence of 3.8% in the US with 11,348 T1D patients aged 2-18 years.…”

Section: Discussionmentioning

confidence: 99%

“…Another study determined that girls had higher lipid levels, among which hypercholesterolemia was the most common, and that age, diabetes duration, increased BMI and A 1C levels were associated with lipid anomalies [24,35]. Polak et al investigated abnormal lipid profiles in children with T1D during puberty and described that cholesterol levels were not associated with metabolic control, while triglyceride levels could have a weak correlation with metabolic control [19]. Heyman et al studied the relationship among diet, physical activity and metabolic control in adolescent girls late in puberty and reported that unhealthy diets and low physical activity lead to impaired metabolic control and increased lipid levels [27].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes

Bulut

Demirel

Metìn

2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Dyslipidemia increases the frequency and severity of micro and macrovascular complications of type 1 diabetes (T1D). The present study aims to determine the prevalence of dyslipidemia and its association with clinical and laboratory findings in diabetic children and adolescents. Methods: The study included 202 children and adolescents with T1D. Demographic data and laboratory findings were obtained from patients files. Results: Dyslipidemia prevalence was found to be 26.2%. Hypercholesterolemia (15.8%) and hyperglyceridemia (12.9%) were most common findings. Age, body mass index (BMI), hemoglobin A 1c (A 1C ) and poor metabolic control were significantly higher in cases with dyslipidemia. Smoking rate was 14.1% in the pubertal group. Poor metabolic control and dyslipidemia was found higher among smokers (p < 0.05).Conclusions: Blood lipid levels should be monitored regularly and nutrition education should be repeated periodically to prevent and control dyslipidemia in patients with T1D. Smoking-related risks should be a part of patient education in the pubertal period.

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Type 1 diabetic children have abnormal lipid profiles during pubertal years 1

Abstract: Plasma CT levels of type I diabetic children are increased in comparison to non-diabetic children and do not follow the usual decreasing pattern during puberty.

Cited by 23 publications

References 14 publications

Dyslipidemia in young patients with type 1 diabetes mellitus

Dyslipidemia in young patients with type 1 diabetes mellitus

Obesity and dyslipidemia – An urgent matter in youth from the general population and in type 1 diabetic patients

The prevalence of dyslipidemia and associated factors in children and adolescents with type 1 diabetes

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