Type 1 diabetes in children is not a predisposing factor for oral yeast colonization

Costa, Ana Luísa; Silva, Branca M.A.; Soares, Rui; Mota, Dálete Delalibera Corrêa de Faria; Alves, Vera; Mirante, Alice; Ramos, João Carlos; Abreu, João Maló; Santos-Rosa, Manuel; Caramelo, Francisco; Gonçalves, Teresa

doi:10.1093/mmy/myw092

Cited by 6 publications

(7 citation statements)

References 33 publications

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“…Regarding the levels of Candida spp. in the oral cavity, there are reports of not only no differences between diabetic and healthy children 3,5,33 , but also of higher levels in diabetic individuals versus the healthy population 16 . Although diabetes was found to be a predisposing factor for candidiasis 55,56 , the findings in the literature are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…For children, a recent study found that T1DM did not confer a higher predisposition for yeast colonisation 33 . The contradictory results and the fact that most of these studies refer to adults justify the investigation of growth patterns of oral Candida spp.…”

Section: Introductionmentioning

confidence: 95%

“…Some studies have shown that reduced metabolic control, increased concentration of glucose in blood and saliva, long duration of the disease and the presence of complications resulting from diabetes are correlated to increased Candida carriage and clinical signs of candidiasis, while other researchers have failed to find such a relationship. For children, a recent study found that T1DM did not confer a higher predisposition for yeast colonisation. The contradictory results and the fact that most of these studies refer to adults justify the investigation of growth patterns of oral Candida spp.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and microbial oral health status in children and adolescents with type 1 diabetes mellitus

Babatzia

Papaioannou

Stavropoulou

et al. 2020

International Dental Journal

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Objectives To study the oral health of young individuals with controlled and uncontrolled type 1 diabetes mellitus (T1DM) and compare the results with those for healthy counterparts. Materials and Methods One‐hundred and forty‐four youngsters (6–15 years of age) were assigned, according to glycaemic control, to three study groups: (i) diabetic patients with poor glycaemic control [glycated haemoglobin (HbA1c ≥7.5%)] (n = 35); (ii) diabetic patients with good glycaemic control (HbA1c <7.5%) (n = 39); and (iii) healthy individuals (n = 70). Plaque, gingival inflammation, calculus and decayed, missing and filled surfaces (DMFS) indices were recorded. Salivary parameters were determined, and stimulated saliva was collected to allow detection and determination of the levels of oral Candida albicans and Streptococcus mutans by real‐time polymerase chain reaction (PCR). Results Significantly different amounts of plaque were found among the study groups (P = 0.024): youngsters with poor glycaemic control had significantly more plaque than youngsters in the other two groups. The gingival, calculus and DMFS indices were not significantly different among groups (P > 0.05). Candida albicans levels were not statistically significant different among groups, but the group with poor glycemic control showed an elevated frequency of detection. Streptococcus mutans was isolated from the oral cavity of 96 of the 144 individuals. A statistically significant difference in the level of S. mutans was found between the group with poor glycaemic control and the healthy control group (P = 0.032). Conclusions The results imply that youngsters with T1DM have a lower level of oral hygiene and are potentially at a higher risk of future oral disease, particularly when their metabolic disorder is uncontrolled. However, factors outside the oral cavity may also have a considerable impact on the initiation and progression of oral diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Clinical and microbial oral health status in children and adolescents with type 1 diabetes mellitus

Babatzia

Papaioannou

Stavropoulou

et al. 2020

International Dental Journal

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“…Yeasts were found in both TD1 and siblings as Costa et al [19] found candidiasis in both TD1 and control populations. The absence of pinworms in the study population is synonymous with their non-participation in the development of type 1 diabetes.…”

Section: Discussionmentioning

confidence: 87%

Biochemical, Infectious and Foods Profiles in Type 1 Diabetics and Their Siblings of Abidjan District, Côte D’ivoire

Judith¹,

Francis²,

Antoinette³

et al. 2017

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Abstract:This work is to measure certain biochemical parameters and to search the blood, intestinal and pinworm parasites, yeasts and foods parameters in type 1 diabetics and their siblings. The study population is constitute of 28 Type 1 diabetics (TD1) and 59 siblings aged between 5 to 21 years, including 41 boys and 46 girls, a sex ratio of 0.89. The mean age of T1D was 12.62 ± 2.75 years and the mean age of the siblings of diabetic's patients was 12.13 ± 4.94 years. TD1 were recruited in C. H. U of Yopougon and Treichville and two NGOs of Côte d'Ivoire. The biochemical parameters were assayed at the laboratory of biochemistry of C. H. U Habib Bourguiba of SFAX, Tunisia. Research of Infectious and foods parameters was carried out Institute Pasteur of Côte d'Ivoire. Study takes place January 2014 to April 2016. Biochemical parameters carried out with Cobas 6000 (Roche / Hitachi). Infectious parameters research was done by direct and Ritchie simplified method, Kato test and scotch anal test. Foods parameters were researched by survey. Phosphorus value was three times greater than normal in certain siblings. There was no difference on the concentration of the biochemical parameters between TD1 and their siblings (p˃0.05). There were presence of blood, intestinal, pinworms parasites and yeast in TD1 and their siblings and unbalanced diet (carbohydrate, protein and lipid) with their siblings (p˂0.0001). TD1 and sibling should be dewormed. Sibling should have balanced diet to avoid clinic diabetes.

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“…Стоматологічні прояви ЦД відзначають у пе-реважної більшості пацієнтів, а деякі фахівцістоматологи вказують на 100% ураження органів і тканин порожнини рота [23]. Найважливішим етіологічним фактором запальних захворювань пародонту визнана бактеріальна мікрофлора, що бере участь у формуванні зубної бляшки, як та, що стимулює запуск імунних реакцій в слизовій оболонці [28]. Запальні захворювання пародонту супроводжуються змінами в системі неспецифічного та специфічного імунітету ротової порожнини [9,44].…”

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Modern Aspects of the Problem of Relationship of Diseases of Periodontal and Diabetes I Type in Children

Кузь¹,

Шешукова²,

Kuz

et al. 2019

Act. Probl. of the Modern Med.

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The literature review considers selected modern scientific publications by foreign, Ukrainian and Russian authors regarding pathological changes in the periodontal tissues of children with type I diabetes. Analysis of scientific sources reveals that diabetes is acquiring the characteristics of omnipresent epidemic not only in Ukraine but also in the global scale. The unprecedented increase in the incidence of type I diabetes, even in children under 3 years of age should be taken into account too. It should be borne in mind that diabetes is characterized by a significant prevalence, lifelong course, early disability and high mortality rates. Although there are a number of authors claiming that dental diseases in children with diabetes are not more pronounced than in healthy ones, the vast majority of scientists still acknowledge such interconnection. They emphasize the regenerative ability of the oral mucosa is reduced, periodontal disease is a complication of diabetes and requires appropriate measures in the form of early diagnosis, prevention and treatment. The review provides information on current views on pathogenetic common features for endocrinological diseases and periodontal pathologies, namely: angiopathy (at the level of blood vessels of the microvasculature), metabolic disorders, changes in lipid peroxidation, autoaggression and the occurrence of secondary immunodeficiency. Research data on the nature and degree of indicators’ changes of oral immunity in chronic catarrhal gingivitis in somatically healthy children and children with concomitant somatic pathology are quite contradictory. There exists a need for further review of existing and conduct modern clinical studies related to biochemical processes in saliva and other body fluids, which could clarify the interrelationship between gingivitis, on the one hand, and type I diabetes, on the other. Thus, a deep and comprehensive study of the abovementioned relationship remains expedient, and the development of therapeutic measures in children with inflammatory periodontal diseases is especially relevant.

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Type 1 diabetes in children is not a predisposing factor for oral yeast colonization

Cited by 6 publications

References 33 publications

Clinical and microbial oral health status in children and adolescents with type 1 diabetes mellitus

Clinical and microbial oral health status in children and adolescents with type 1 diabetes mellitus

Biochemical, Infectious and Foods Profiles in Type 1 Diabetics and Their Siblings of Abidjan District, Côte D’ivoire

Modern Aspects of the Problem of Relationship of Diseases of Periodontal and Diabetes I Type in Children

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