Two-year Rehospitalization Rates of Patients with Newly Diagnosed or Chronic Schizophrenia on Atypical or Typical Antipsychotic Drugs: Retrospective Cohort Study

Herceg, Miroslav; Jukić, Vlado; Vidović, Domagoj; Erdeljić, Viktorija; Ćelić, Ivan; Kozumplik, Oliver; Bagarić, Dario; Radić, Maja Silobrčić

doi:10.3325/cmj.2008.2.215

Cited by 23 publications

(14 citation statements)

References 22 publications

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“…While the suicide rate is lower compared with other estimates for people with schizophrenia, the relatively higher level observed near the onset of illness in the current study is in agreement with other assessments of suicidality in schizophrenia 29 . The mean age of the chronic patient cohort was significantly older than that for the recently diagnosed patients and consistent with other assessments of schizophrenia patients with chronic disease 30 . The greater proportion of recently diagnosed patients observed with episodic mood disorders, unspecified diagnosis, or schizophrenia diagnoses other than paranoid or schizoaffective, may be ascribed to more difficulties in precise diagnosis during the early stage of psychotic illness, particularly prior to the first schizophrenia event.…”

Section: Discussionsupporting

confidence: 68%

Burden of schizophrenia in recently diagnosed patients: healthcare utilisation and cost perspective

Nicholl

Akhras

Diels³

et al. 2010

Current Medical Research and Opinion

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Section: Discussionsupporting

confidence: 68%

Burden of schizophrenia in recently diagnosed patients: healthcare utilisation and cost perspective

Nicholl

Akhras

Diels³

et al. 2010

Current Medical Research and Opinion

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“…We included 37 studies in the meta‐analysis : three randomised controlled trials and 34 observational studies (Table ). Studies were published between 1990 and 2016.…”

Section: Resultsmentioning

confidence: 99%

The impact of clozapine on hospital use: a systematic review and meta‐analysis

Land

Siskind

McArdle

et al. 2017

Acta Psychiatr Scand

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The impact of clozapine on hospital use: a systematic review and metaanalysis.Objective: The objective of this study was to perform a systematic review and meta-analysis of studies reporting the impact of clozapine on hospital use in people with a psychotic illness. Method: PubMed, EMBASE, PsycINFO and the Cochrane Schizophrenia Group Trials Register were systematically searched from inception to 12 October 2016. We included all trials and observational studies, except case reports. Results: Thirty-seven studies were included. Clozapine significantly reduced the proportion of people hospitalised compared to control medicines (RR = 0.74; 95% CI: 0.69-0.80, P < 0.001, 22 studies, n = 44 718). There were significantly fewer bed days after clozapine treatment compared to before clozapine treatment in both controlled (MD = À34.41 days; 95% CI: À68.22 to À0.60 days, P = 0.046, n = 162) and uncontrolled studies (MD = À52.86 days; 95% CI: À79.86 days to À25.86 days, P < 0.001, n = 2917). Clozapine and control medicines had a similar time to rehospitalisation (À19.90 days; 95% CI: À62.42 to 22.63 days, P = 0.36). Conclusion: Clozapine treatment reduced the number of people hospitalised and the number of bed days after treatment compared with before treatment. Clozapine has the potential to reduce acute hospital use among people with treatment refractory schizophrenia.

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“…First, unlike most previous studies that explored significant predictors for readmission rates within a fixed period of time after discharge, our study investigated the predictors of readmission within different periods of time after discharge using the same study cohort. This approach may have important healthcare policy implications because the predictors for readmission very close to discharge and those for readmission distant from discharge might be different,9,17 and the difference between readmission rates close to and remote from discharge can be used to assess the adequacy of aftercare for psychiatric patients. Second, the number of previous hospitalizations has consistently been found to be a risk factor for readmission 11–13,16,29,30.…”

Section: Discussionmentioning

confidence: 99%

Predictors of psychiatric readmissions in the short- and long-term: a population-based study in taiwan

Lin

Chen

Lin

et al. 2010

Clinics

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OBJECTIVESTo explore the risks and rates of readmission and their predictors 14 days, one year, and five years after discharge for the psychiatric population in Taiwan.METHODSThis was a prospective study based on claims from 44,237 first-time hospitalized psychiatric patients discharged in 2000, who were followed for up to five years after discharge. The cumulative incidence and incidence density of readmission were calculated for various follow-up periods after discharge, and Cox proportional hazard models were generated to identify the significant predictors for psychiatric readmission.RESULTSThe less than 14-day, one-year, and five-year cumulative incidences were estimated at 6.1%, 22.3%, and 37.8%, respectively. The corresponding figures for incidence density were 4.58, 1.04, and 0.69 per 1,000 person-days, respectively. Certain factors were significantly associated with increased risk of readmission irrespective of the length of follow-up, including male gender, length of hospital stay >15 days, economic poverty, a leading discharge diagnosis of schizophrenia/affective disorders, and residence in less-urbanized regions. Compared to children/adolescents, young adults (20–39 years) were significantly associated with increased risks of

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Two-year Rehospitalization Rates of Patients with Newly Diagnosed or Chronic Schizophrenia on Atypical or Typical Antipsychotic Drugs: Retrospective Cohort Study

Abstract: Rehospitalization rates of patients who were prescribed atypical antipsychotic drugs were similar to those of patients who were prescribed typical antipsychotic drugs for both the group with the first psychotic episode and group with chronic schizophrenia.

Cited by 23 publications

References 22 publications

Burden of schizophrenia in recently diagnosed patients: healthcare utilisation and cost perspective

Burden of schizophrenia in recently diagnosed patients: healthcare utilisation and cost perspective

The impact of clozapine on hospital use: a systematic review and meta‐analysis

Predictors of psychiatric readmissions in the short- and long-term: a population-based study in taiwan

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