Two-year observation of the clinical efficacy in treating chronic hepatitis B patients with Ganxian recipe and lamivudine

Shen, Weisheng; Yang, Hongzhi; Qian, Hong; Zhang, Yongqiang; Xie, Hui; Bian, Zhuang

doi:10.1007/bf02835740

Cited by 7 publications

(8 citation statements)

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“…Among these included studies, a study recruited schistosomiasis japonica patients only [20], the remaining recruited patients with chronic HBV infection. All of the identified studies were conducted in China and published in Chinese language, and only one study was published in English language [21]. Three studies used three-arm study design (2 intervention groups compared with 1 control group, or 1 intervention group compared with 2 control groups) [21-23] and others used two-arm study design (1 intervention group versus 1 control group) [20,24-42].…”

Section: Resultsmentioning

confidence: 99%

“…All of the identified studies were conducted in China and published in Chinese language, and only one study was published in English language [21]. Three studies used three-arm study design (2 intervention groups compared with 1 control group, or 1 intervention group compared with 2 control groups) [21-23] and others used two-arm study design (1 intervention group versus 1 control group) [20,24-42]. No study reported mortality, liver cirrhosis or cancer, quality of life or cost as outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…None of the studies described the method of allocation concealment. Only one study reported using blinding design (single blind without description of the blinding method) [21] and three studies used placebos [20,30,41]. Six studies did not provide the information on missing data [28,29,33-35,41].…”

Section: Resultsmentioning

confidence: 99%

“…Among these, three reported no adverse event in both groups [31,32,35] while one reported no adverse event for CHM [30]. Five reported gastrointestinal discomfort and drug-allergic symptoms for CHM, placebo, IFN and LVD [20,21,27,30,41]. One reported two cases with dizziness using the combined treatment [21].…”

Section: Resultsmentioning

confidence: 99%

“…Five reported gastrointestinal discomfort and drug-allergic symptoms for CHM, placebo, IFN and LVD [20,21,27,30,41]. One reported two cases with dizziness using the combined treatment [21]. Other adverse symptoms of flu-like symptoms or mild leucopenia and thrombocytopenia were related to the use of IFN or LVD [21,22,27].…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials

et al. 2012

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BackgroundThe studies on the effectiveness of Chinese herbal medicines (CHM) in treating liver fibrosis (LF) were not consistent. This study aims to systematically review the effectiveness of CHM on treating LF patients.MethodsDatabases including MEDLINE, AMED, EMBASE, The Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, TCMOnline, Chinese Biomedical Literature Database, and Chinese Medical Current Contents were searched up to March 2011. Randomized controlled trials (RCTs) involving LF patients receiving CHM, Western medicine, combined CHM and Western medicine compared with placebo, Western medicine or no intervention were included. LF markers including serum hyaluronic acid (HA), laminin (LN), procollagen type III (PC-III), type IV collagen (IV-C), matrix metalloproteinase (MMP), and tissue inhibitors of metalloproteinase (TIMP) were measured as primary outcomes. Liver biochemistry, including alanine aminotransferase (ALT) and aspartarte aminotransferase (AST), and improvement of related clinical symptoms were measured as secondary outcomes. Risk of bias of allocation sequence, allocation concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases were assessed.ResultsTwenty-three RCTs with 2123 participants were analyzed in subgroups of types of comparison and study quality. Fifteen studies were graded as good quality. CHM alone and combined with Western medicine showed significant improvements in HA, LN, PC-III and IV-C compared with Western medicine alone. However, there were no significant differences observed between CHM and placebo treatments.ConclusionThe current inconclusive results in determining the effectiveness of CHM treatment on LF, due to the poor methodological quality and high heterogeneity of the studies, suggests that large RCTs using standardized Chinese medicine syndrome diagnosis and CHM formulae with longer follow-up are required for further evaluation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials

et al. 2012

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Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B

Kong

Liang

Yang

et al. 2019

Cochrane Database of Systematic Reviews

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Licorice and liver function in patients with primary liver disease: A systematic review and meta‐analysis of RCTs

Giangrandi,

Dinu,

Napoletano

et al. 2024

Phytotherapy Research

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Licorice (Glycyrrhiza spp.) has been a cornerstone of traditional Chinese and Japanese medicine. This systematic review and meta‐analysis aimed to evaluate the efficacy of licorice formulations, alone or in combination with other herbs, on liver function enzymes in patients with primary liver disease. We systematically searched MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library up to April 2024. Randomized controlled trials (RCTs) comparing the effects of Glycyrrhiza spp. preparations versus placebo or standard of care controls were included. Standard Cochrane methods were used to extract data and appraise eligible studies. A total of 15 RCTs, involving 1367 participants, were included in the analysis. The studies varied widely in geographical location, duration, and licorice preparations used. Licorice significantly reduced alanine aminotransferase (ALT) by 15.63 U/L (95% CI: −25.08, −6.18; p = 0.001) and aspartate aminotransferase (AST) by 7.37 U/L (95% CI: −13.13, −1.61; p = 0.01) compared to control groups. Subgroup analyses revealed that purified glycyrrhizic acid compounds were particularly effective, showing greater reductions in ALT and AST without significant heterogeneity. Although licorice treatment did not significantly impact gamma‐glutamyl transferase and total bilirubin (TBIL) levels overall, specific licorice‐herb preparations did show a notable reduction in TBIL. The safety profile of licorice was consistent with known side effects, predominantly mild and related to its mineralocorticoid effects. Despite heterogeneity and potential language bias, the findings suggest that licorice can enhance liver function. Further studies should standardize licorice preparations and explore its role in multifaceted herbal formulations to better understand its hepatoprotective mechanisms.

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Two-year observation of the clinical efficacy in treating chronic hepatitis B patients with Ganxian recipe and lamivudine

Abstract: GXR could inhibit the appearance of YMDD after long-term application of LVD, and combined use has marked synergism.

Cited by 7 publications

References 2 publications

Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials

Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials

Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B

Licorice and liver function in patients with primary liver disease: A systematic review and meta‐analysis of RCTs

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