Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B

Kong, De Zhao; Liang, Ning; Yang, Guan Lin; Zhang, Zhe; Liu, Yue; Li, Jing; Liu, Xuehan; Liang, Shi-Bing; Nikolova, Dimitrinka; Jakobsen, Janus Christian; Gluud, Christian; Liu, Jianping

doi:10.1002/14651858.cd013090.pub2

Cited by 20 publications

(13 citation statements)

References 116 publications

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“…Furthermore, the Health Commission of Shenzhen Municipality united with Beijing University of traditional Chinese medicine Shenzhen hospital, began to conduct comprehensive intervention of TCM during the convalescent of COVID-19 patients. More than three herbal formulas are recommended for rehabilitation of recovering cases, such as Shen ling bai zhu san 19 , Xiao chai hu tang 20 and personalized treatments. These formulae could be presumably as rehabilitative measure for the convalescents of COVID-19 at SSMC.…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19

An¹,

Yuan²,

Wang³

et al. 2021

Int. J. Med. Sci.

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Section: Methodsmentioning

confidence: 99%

Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19

An¹,

Yuan²,

Wang³

et al. 2021

Int. J. Med. Sci.

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“…The CHD cohorts were separated from the DCM cohorts in the two-dimensional score plots ( Figure 5A ). Similarly, we performed one-way ANOVA between all the differential metabolites mentioned in the previous section, discovering that C14-OH, Cit, Arg, Aspartic acid ( 25 ), Glutamine acid ( 26 ), and Piperine (Pip) changed more drastically in DCM than in CHD ( Figure 5B ).…”

Section: Resultsmentioning

confidence: 95%

Characteristics of Blood Metabolic Profile in Coronary Heart Disease, Dilated Cardiomyopathy and Valvular Heart Disease Induced Heart Failure

Liu

et al. 2021

Front. Cardiovasc. Med.

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Purpose: Metabolic impairment is one key contributor to heart failure (HF) pathogenesis and progression. The major causes of HF, coronary heart disease (CHD), dilated cardiomyopathy (DCM), and valvular heart disease (VHD) remains poorly characterized in patients with HF from the view of metabolic profile. We sought to determine metabolic differences in CHD-, VHD-, and DCM-induced HF patients and identify significantly altered metabolites and their correlations.Procedure: In this study, a total of 96 HF cases and 97 controls were enrolled. The contents of 23 amino acids and 26 carnitines in fasting plasma were measured by a targeted liquid chromatography and mass spectrometry (LC-MS) approach.Results: Nine metabolites (Histidine, Arginine, Citrulline, Glutamine, Valine, hydroxyhexadecenyl-carnitine, acylcarnitine C22, hydroxytetradecanoyl-carnitine, and carnitine) were found to be related with the occurrence of HF. Arginine, Glutamine and hydroxytetradecanoyl-carnitine could effectively distinguish CHD and DCM patients, and hydroxytetradecanoyl-carnitine and aspartic acid were able to classify CHD and VHD cohorts.Conclusion: This study indicated that circulating amino acids and long-chain acylcarnitine levels were closely associated with progression of heart failure. Monitoring these metabolic alterations by LC-MS may help the differentiation of CHD, VHD, and DCM in the early stage, and provide new diagnostics targets or therapeutic interventions.

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“…[ 11 ] Evidence-based medicine has shown that antiviral therapy plus traditional Chinese medicine has better long-term control effect on HBVC than antiviral treatment alone. [ 11 , 12 , 40 , 41 ] LWWL tablet is a famous plant-derived traditional Chinese medicine preparation against hepatic fibrosis and cirrhosis which produced by Shandong Shibo Jindu Pharmaceutical Co., Ltd. It have been approved by Chinese State Food and Drug Administration, and granted the manufacturing approve number accordingly (Z20060238).…”

Section: Discussionmentioning

confidence: 99%

Effect of Liuweiwuling tablet on biochemical and virological parameters, and quality of life in patients with hepatitis B virus-related cirrhosis

Ding¹,

Zhu²,

Zhou

et al. 2020

Medicine

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Background: Liuweiwuling (LWWL) tablet, a kind of plant-derived traditional Chinese medicine preparation, has been widely applied as a promising adjunctive drug for hepatitis B virus-related cirrhosis (HBVC). However, its exact clinical efficacy and safety is still not well investigated. In this study, we aimed to summarize the efficacy of LWWL tablet on biochemical and virological parameters, and quality of life (QoL) in patients with HBVC through the meta-analysis. Methods: All available randomized controlled trials and high-quality prospective cohort studies that investigated the efficacy and safety of LWWL for patients with HBVC were searched from the following electronic databases: PubMed, Medline, Cochrane Library, Google Scholar, Web of Science, Excerpt Medica Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, China Scientific Journal Database, and Wanfang Database. Papers in Chinese or English published from January 2000 to August 2020 will be included without any restrictions. Study selection and data extraction will be performed independently by 2 authors. The clinical outcomes including biochemical (liver function and fibrosis indexes) and virological parameters, QoL, immune function and adverse events, were systematically evaluated. Review Manager 5.3 and Stata 14.0 were used for data synthesis, sensitivity analysis, meta regression, subgroup analysis, and risk of bias assessment. Results: The results of this study will be published in a peer-reviewed journal, and provide a helpful evidence for clinicians to formulate the best postoperative adjuvant treatment strategy for HBVC patients. Conclusion: Our study will draw an objective conclusion of the efficacy of LWWL on biochemical and virological parameters, and QoL in patients with HBVC. INPLASY registration number: INPLASY202080010.

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Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B

Abstract: Tang, a herbal medicine, for chronic hepatitis B.

Cited by 20 publications

References 116 publications

Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19

Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19

Characteristics of Blood Metabolic Profile in Coronary Heart Disease, Dilated Cardiomyopathy and Valvular Heart Disease Induced Heart Failure

Effect of Liuweiwuling tablet on biochemical and virological parameters, and quality of life in patients with hepatitis B virus-related cirrhosis

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