Two‐Year Follow‐up of a Randomized Controlled Nutrition Intervention Trial in Very Low‐Birth‐Weight Infants

Roelants, Jorine; Vlaardingerbroek, Hester; Akker, Chris H.P. van den; Jonge, Rogier C. J. de; Goudoever, Johannes B. van; Vermeulen, Marijn J.

doi:10.1177/0148607116678196

Cited by 35 publications

(39 citation statements)

References 37 publications

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“…The study of Blanco et al was a secondary analysis of a study originally designed with the aim of reducing hyperkalaemia and it was not powered for neurodevelopment. Recent, larger studies did not observe short [48] or long term beneficial effects of increasing amino acid in the early phase [49,50]. Morgan et al showed an improved head circumference growth by both increasing parenteral amino acid and caloric intake, so no definite conclusion can be drawn on the effect of amino acids alone [21].…”

Section: High Versus Low Amino Acid Intakesmentioning

confidence: 99%

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Amino acids

Goudoever

Pipaon

Braegger³

et al. 2018

Clinical Nutrition

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160

157

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Section: High Versus Low Amino Acid Intakesmentioning

confidence: 99%

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Amino acids

Goudoever

Pipaon

Braegger³

et al. 2018

Clinical Nutrition

Self Cite

160

157

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“…Among these, 6145 studies were excluded after reviewing titles and abstracts, leaving 53 articles for full text review for eligibility ( Figure 1 ). Finally, nine studies were selected with proper eligibility [ 9 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. One study [ 20 ], which was a planned follow-up of a previous RCT [ 19 ], was based on the same population and was therefore considered an identical study.…”

Section: Resultsmentioning

confidence: 99%

Safety and Efficacy of Early High Parenteral Lipid Supplementation in Preterm Infants: A Systematic Review and Meta-Analysis

Kim

2021

Nutrients

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The objective of this systematic review and meta-analysis was to summarize the effects of early initiation and achievement of a high dose of parenteral lipids (≥1.5 g/kg/day reached within the first 24 h of birth) on growth and adverse outcomes in preterm infants. PubMed, EMBASE, and Cochrane databases were utilized to search for publications for this meta-analysis. Randomized controlled trials were eligible if data on growth or clinical outcome was available. The search returned nine studies. The mean proportion of postnatal weight loss (%) was lower (mean difference [MD]: −2.73; 95% confidence interval [CI]: −3.69, −1.78), and the mean head circumference near the term equivalent age (cm) was higher in the early high lipid treatment group (MD: 0.67; 95% CI: 0.25, 1.09). There was a favorable association of early high lipid administration with the incidence of extrauterine growth restriction (relative risk [RR]: 0.27; 95% CI: 0.15, 0.48). Generally, there were no differences in morbidities or adverse outcomes with early high lipid administration. Early initiation of parenteral lipids and high dose achieved within the first 24 h of life appear to be safe and endurable and offer benefits in terms of growth.

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“…In other study by Jorine A. Roelants et al to determine the effect of early aggressive parenteral nutrition (PN) on long-term outcome in very low birth weight newborns, the findings demonstrated that the he primary use of highdose amine-acid administration and mixed fat emulsions, although improving the growth, has no positive effect on neuronal growth in very low birth weight newborns [23]. The study by dit Trolli SE to determine of the effect of cumulative intakes of proteins, carbohydrates, lipids and energy during the first 28 days of life on the weight gain in the first 28 days of life, showed that there is a significant statistical association between the cumulative lipid intake at 14 days of life with the developmental quotient (P-Value: 0.04) [24].…”

Section: Discussionmentioning

confidence: 98%

Determination of the Effect of High-Dose Intralipid in Compared to Its Gradual Dose in Very Low Birth Weight Newborns: A Case-control Study

Kashaki

Bordbar

Mazouri

et al. 2019

JPRI

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Objective: The aim of this study was to determine the effect of high dose intralipid in compared to its gradual dose in very low birth weight newborns in Iran. Methods: This study was a case-control study that conducted on 104 very low birth weight infants (<1500 g) referred to Akbarabadi hospital of Tehran (Iran) in 2016. The infants were randomly assigned to two groups (case group: 52 vs. control group: 52). The control group received intralipid 20% with a dose of 1 g/kg/24 h in the first and second day of the study, then from 3rd day to 3 g/kg /24h was raised. But, the case group received 3 g/kg/24 h of intralipid 20% from the first day and continued until the end of the study. In both groups, the study lasted for up to 30 days. Data were collected and analyzed using SPSS22 software. Also P-Value <0.05 was considered as a significant level. Results: The results showed mean daily weight gain in case group is higher than control group and this difference was significant statistically (P-Value < 0.05). Also, although the mean of blood sugar, triglyceride, HCO3, the number of positive blood culture and the number of positive CPR in case group were higher than control group, but these differences were not statistically significant (P-Value >0.05). Conclusion: Given that the better and faster growth of newborns in the intralipid group with high-dose in compared to intralipid group with gradual dose, the use of higher initial doses is recommended in newborns with very low birth weight.

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Two‐Year Follow‐up of a Randomized Controlled Nutrition Intervention Trial in Very Low‐Birth‐Weight Infants

Abstract: This randomized controlled hypothesis-generating study demonstrated no beneficial effect of early high-dose AA administration and mixed fat emulsions on survival and neurodevelopmental outcome in VLBW infants, although growth was enhanced.

Cited by 35 publications

References 37 publications

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Amino acids

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Amino acids

Safety and Efficacy of Early High Parenteral Lipid Supplementation in Preterm Infants: A Systematic Review and Meta-Analysis

Determination of the Effect of High-Dose Intralipid in Compared to Its Gradual Dose in Very Low Birth Weight Newborns: A Case-control Study

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