Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus)

Chang, Xiaotian; Kobayashi, Takeaki; Senthilkumaran, B.; Kobayashi-Kajura, Hiroko; Sudhakumari, C.C.; Nagahama, Yoshitaka

doi:10.1016/j.ygcen.2004.11.020

Cited by 158 publications

(92 citation statements)

References 54 publications

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“…High aromatase activity levels in the brain of adult teleosts have been suggested to play a role in sexual plasticity (Forlano et al, 2001). In our study, both cyp19a1a and cyp19a1b could be detected in carp kidney, consistent with previous reports in pejerrey fish (Strobl-Mazzulla et al, 2005) and nile tilapia (Chang et al, 2005). Interestingly, cyp19a1b was not detectable in kidney of male carp.…”

Section: Discussionsupporting

confidence: 92%

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Tang

Hao

et al. 2010

General and Comparative Endocrinology

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Section: Discussionsupporting

confidence: 92%

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Tang

Hao

et al. 2010

General and Comparative Endocrinology

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“…1. Additionally, a new conserved amino acid sequence (DFATELIFAQN) was also revealed in the teleost brain-type isoforms, in addition to the C-terminus conserved sequence (LAMRFIPR), which was reported previously by Chang et al (2005).…”

Section: Discussionsupporting

confidence: 65%

“…In teleosts, a negative dose-dependent dopaminergic effect via the CREB binding site has been observed recently in grey mullet brain-type Cyp19a1b promoter in vitro (Nocillado et al, 2006). Although CREB binding sites have been identified in the Cyp19a1a promoters of medaka (Tanaka et al, 1995), zebrafish (Kazeto et al, 2001;Tong and Chung, 2003) and tilapia (Chang et al, 2005), attempts to illustrate the role of CREB motif in relation to promoter activity are limited. In the present transient transfection and luciferase assays, a peak activity with double increase was revealed in the −1010/+105 construct containing a CREB binding site, suggesting that CREB motif should be an alternative and powerful site for controlling EaCyp19a1a promoter activation in teleost fishes (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Cyp19a1a/b promoters were already isolated in some fishes and amphibians, such as medaka Oryzias latipes (Tanaka et al, 1995), goldfish Carassius auratus (Tchoudakova et al, 2001), zebrafish (Kazeto et al, 2001;Tong and Chung, 2003), Nile tilapia (Yoshiura et al, 2003;Chang et al, 2005), gobiid fish Trimma okinawae , European sea bass Dicentrarchus labrax L. (Galay-Burgos et al, 2006), grey mullet Mugil cephalus (Nocillado et al, 2006), Xenopus laevis (Akatsuka et al, 2005), and frog Rana rugosa (Oshima et al, 2006). And, some putative regulatory elements were also identified from some fish promoters (Yoshiura et al, 2003;Gardner et al, 2005;Nocillado et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Expression pattern, cellular localization and promoter activity analysis of ovarian aromatase (Cyp19a1a) in protogynous hermaphrodite red-spotted grouper

Huang

Zhou

et al. 2009

Molecular and Cellular Endocrinology

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“…In fish the role of brain aromatase in establishing behavioral sexual differentiation is less clear. In the Nile tilapia and in zebrafish there were no differences in aromatase brain mRNA expression levels between males and females during gonadal differentiation (Kallivre-taki et al, 2007;Chang et al, 2005) and in seabass females presented higher levels of brain aromatase mRNA expression during the period of gonadal differentiation but this pattern was reversed shortly after (Blásquez and Piferrer, 2004; see also Piferrer et al, 2005). A role for brain aromatase in regulating sexual behavior in adult fish seems to be more evident.…”

Section: Introductionmentioning

confidence: 99%

Brain and gonadal aromatase activity and steroid hormone levels in female and polymorphic males of the peacock blenny Salaria pavo

Gonçalves

Teles

Alpedrinha

et al. 2008

Hormones and Behavior

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In the peacock blenny Salaria pavo large males with well-developed secondary sexual characters establish nests and attract females while small "sneaker" males mimic female sexual displays in order to approach the nests of larger males and parasitically fertilize eggs. These alternative reproductive tactics are sequential, as sneakers irreversibly switch into nesting males. This transition involves major morphologic and behavioral changes and is likely to be mediated by hormones. This study focuses on the role of aromatase, an enzyme that catalyses the conversion of androgens into estrogens, in the regulation of male sexual polymorphism in S. pavo. For this, sex steroid plasma levels and aromatase activity (AA) in gonads, whole brain and brain macroareas were determined in sneakers, transitional males (i.e. sneakers undergoing the transition into nesting males), nesting males and females collected in the field. AA was much higher in ovarian tissue than in testicular tissue and accordingly circulating estradiol levels were highest in females. This supports the view that elevated AA and estradiol levels are associated with the development of a functional ovary. Transitional males are in a non-reproductive phase and had underdeveloped testes when compared with sneakers and nesting males. Testicular AA was approximately 10 times higher in transitional males when compared with sneakers and nesting males, suggesting high AA has a suppressive effect on testicular development. Nesting males had significantly higher plasma levels of both testosterone (T) and 11-ketotestosterone when compared with the other male morphs and previous studies demonstrated that these androgens suppress female-like displays in sneakers. In the brain, AA was highest in macroareas presumably containing hypothalamic nuclei traditionally associated with the regulation of reproductive behaviors. Overall, females presented the highest levels of brain AA. In male morphs AA increased from sneakers, to transitional males, to nesting males in all brain macroareas. These results suggest that the transition into the nesting male tactic is accompanied both by an increase in testicular androgen production and by a higher conversion of androgens into estrogens in the brain. The increase in androgen production is likely to mediate the development of male secondary sexual characters while the increase in brain AA may be related to the behavioral changes associated with tactic transition.

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Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus)

Cited by 158 publications

References 54 publications

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Expression pattern, cellular localization and promoter activity analysis of ovarian aromatase (Cyp19a1a) in protogynous hermaphrodite red-spotted grouper

Brain and gonadal aromatase activity and steroid hormone levels in female and polymorphic males of the peacock blenny Salaria pavo

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