Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee

Peterson, Lars; Minas, T.; Brittberg, Mats; Nilsson, Anders; Sjögren‐Jansson, Eva; Lindahl, Anders

doi:10.1097/00003086-200005000-00020

Cited by 1,348 publications

(1,130 citation statements)

References 27 publications

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“…One long-term 5-year followup study documented a similar failure rate of 23% in patients having ACI and microfracture [14]. For ACI, previous studies described failure rates between 5% [24] and 13% [20] and the necessity for revision surgery of 25% [20]. In relation to these findings, we presume the use of PGAhyaluronan scaffolds immersed with PRP are associated with low complication rates and allows durable repair.…”

Section: Discussionmentioning

confidence: 57%

A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year

Siclari

Mascaro

Gentili

et al. 2012

Clinical Orthopaedics &Amp; Related Research

116

113

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Section: Discussionmentioning

confidence: 57%

A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year

Siclari

Mascaro

Gentili

et al. 2012

Clinical Orthopaedics &Amp; Related Research

116

113

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“…Periosteal complications including fibrous overgrowth and periosteal delamination are well described in the literature. Peterson et al [24] reported the incidence to be as high as 40% (26 of 65 joints) assessed by second-look arthroscopy. In patients requiring reoperation postimplantation, Henderson et al [12] reported that the most common finding at surgery was periosteal hypertrophy or extrusion, which was painful in 19.2% of patients and tended to occur in the first 2 years from implantation.…”

Section: Discussionmentioning

confidence: 99%

Cell-based Therapy Improves Function in Adolescents and Young Adults With Patellar Osteochondritis Dissecans

Teo

Buhary

Tai

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Recent advances have been made in using chondrocytes and other cell-based therapy to treat cartilage defects in adults. However, it is unclear whether these advances should be extended to the adolescent and young adult-aged patients. Questions/purposes We assessed cell-based surgical therapy for patellar osteochondritis dissecans (OCD) in adolescents and young adults by (1) determining function with the International Knee Documentation Committee (IKDC) subjective and Lysholm-Gillquist scores; and (2) evaluating activity level using the Tegner-Lysholm scale. Methods We retrospectively reviewed 23 patients between 12 and 21 years of age (mean 16.8 years) treated for OCD lesions involving the patella from 2001 to 2008. Twenty patients had autologous chondrocyte implantation and three patients had cultured bone marrow stem cell implantation. There were 19 males and four females. We obtained preoperative CT scans to assess patella subluxation, tilt, and congruence angle to determine choice of treatment. We obtained IKDC subjective knee evaluation scores, Tegner-Lysholm activity levels, and LysholmGillquist knee scores preoperatively and at 6, 12, and 24 months postoperatively. Results Mean IKDC score, Tegner-Lysholm outcomes, and Lysholm-Gillquist scale improved from 45, 2.5, and 50, respectively, at surgery to 75, 4, and 70, respectively, at 24-month followup. Complications include periosteal hypertrophy observed in two patients. Conclusion Cell-based therapy was associated with shortterm improvement in function in adolescents and young adults with patellar

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“…When properly sealed, the periosteal flap contains the cells and they generate new cartilage. 16,17 No scaffold was involved in this procedure. Use of a scaffold could simplify the second surgery and enhance retention of the cells in the lesion.…”

Section: Tissue Engineering For Musculoskeletal Deficienciesmentioning

confidence: 99%

Collagen scaffolds for tissue engineering

2007

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There are two major approaches to tissue engineering for regeneration of tissues and organs. One involves cell‐free materials and/or factors and one involves delivering cells to contribute to the regeneraion process. Of the many scaffold materials being investigated, collagen type I, with selective removal of its telopeptides, has been shown to have many advantageous features for both of these approaches. Highly porous collagen lattice sponges have been used to support in vitro growth of many types of tissues. Use of bioreactors to control in vitro perfusion of medium and to apply hydrostatic fluid pressure has been shown to enhance histogenesis in collagen scaffolds. Collagen sponges have also been developed to contain differentiating‐inducing materials like demineralized bone to stimulate differentiation of cartilage tissue both in vitro and in vivo. © 2007 Wiley Periodicals, Inc. Biopolymers 89: 338–344, 2008.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

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Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee

Cited by 1,348 publications

References 27 publications

A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year

A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year

Cell-based Therapy Improves Function in Adolescents and Young Adults With Patellar Osteochondritis Dissecans

Collagen scaffolds for tissue engineering

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