Abstract:Two complementary radiosynthetic routes to the potent PNMT inhibitor 7,8-dichloro-1 ,2,3,4-tetrahydroisoquinol i ne-l -l 4C(1) from 2,3-dichl orobenzal dehydeformyl-C(Q) are described. In the Pomeranz-Fritsch sequence isoquinoline 6 was prepared from Schiff's base 2.furnished 1 in 28% radiochemical yield from 4. sequence, 4 was converted via amino alcohol 7 to chloro amine 6. the latter with aluminum chloride/ammonium chloride (fusion, 190 "C) yielded labeled Jin 31% radiochemical yield from 2. 14 -Catalytic h… Show more
“…Tetrahydroisoquinolines 8 and 9 were synthesized according to a modification of a procedure described in ref. 19. The starting amino alcohol (2.5 mmol) was dissolved in decalin (1 ml) in a 25 ml flask equipped with reflux condenser and magnetic stirrer under dry Ar.…”
“…Tetrahydroisoquinolines 8 and 9 were synthesized according to a modification of a procedure described in ref. 19. The starting amino alcohol (2.5 mmol) was dissolved in decalin (1 ml) in a 25 ml flask equipped with reflux condenser and magnetic stirrer under dry Ar.…”
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