Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometry and comparative genomic hybridization

Liu, Xiuping; Satô, Toshihiko; Oga, Atsunori; Ikemoto, Kenzou; Kawauchi, Shigeto; Ikeda, Eiichi; Sasaki, Kohsuke

doi:10.3892/ijo.25.3.615

Cited by 14 publications

(15 citation statements)

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“…37,38 Numerical abnormalities of chromosome 18 have been described in several neoplasia, namely of the gastrointestinal tract. [39][40][41] In the work of Liu et al, 39 the gain or amplification of 18p in mucinous colorectal neoplasia was associated with aneuploidy and aggressive behavior. Stocks et al 41 were able to separate junctional from distal gastric tumors based on a panel of genetic abnormalities, which includes numerical aberration of 18q.…”

Section: Discussionmentioning

confidence: 98%

Chromosomal analysis of Barrett's cells: demonstration of instability and detection of the metaplastic lineage involved

et al. 2007

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Barrett's esophagus is lined by columnar and goblets cells with gastric and intestinal characteristics. Despite the association between goblet elements and malignancy, it was not demonstrated that other columnar cells lineages are not related to neoplasia. Chromosomal abnormalities were described in metaplasia adjacent to Barrett's neoplasia, but it is unknown which metaplastic lineages are involved. This work assessed the frequency and the type of chromosomal abnormalities in Barrett's esophagus without neoplasia and performed the identification of the metaplastic cells carrying chromosomal gains. Barrett's esophagus biopsies were collected and processed for short-term cell culture and cytogenetic analysis. Combined immunofluorescence/ fluorescence in situ hybridization was performed in cases exhibiting chromosomal gains by using antisera against intestinal (MUC2) and gastric (MUC5AC and MUC6) apomucins and chromosome pericentromeric alpha satellite DNA probes for the chromosomes involved. Each case was scored for the number of spots (0, 1, 2, 42) in 200 nonoverlapping nuclei. Columnar and goblet cells were separately assessed. Short-term cell cultures were achieved in 40/60 cases (67%). There were clonal abnormalities in 27/40 cases (68%) and tetraploid (4n) clones in 10/40 (25%). Structural alterations were detected in 14/40 (35%) with recurrent breakpoints at 1q21, 15q15 and 15q22. Numerical changes (trisomies 7 and 18 and loss of Y) occurred in 16/40 (40%). Gains of chromosomes 7 and 18 were more frequent in columnar than in goblet cells (9.8% vs 0.7% (Po0.05)) and (7.9 vs 1.9% (Po0.05)) respectively. These alterations were detected in cells exhibiting gastric as well as intestinal features and were more frequent in cells without apomucin production. Conclusions: (1) chromosomal instability is a common finding in Barrett's esophagus without neoplasia. (2) The two metaplastic populations are committed, chromosomal gains being more frequent in columnar nongoblet than in goblet cells. (3) The two metaplastic phenotypes, gastric and intestinal, are equally involved.

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Section: Discussionmentioning

confidence: 98%

Chromosomal analysis of Barrett's cells: demonstration of instability and detection of the metaplastic lineage involved

et al. 2007

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“…Leopoldo et al and Liu et al identified two subtypes of mucinous adenocarcinoma of colorectal cancer [23,24]. The MAC with MSI (microsatellite instability) phenotype presented an earlier TNM stage, a lower frequency of cancer recurrence and better survival compared with conventional adenocarcinoma and MSS (microsatellite stable) mucinous tumors.…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas

Song

Xiao

2017

Cell Physiol Biochem

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Background/Aims: The local excision of early colorectal cancer is limited by the presence of lymph node metastasis (LNM). Signet-ring cell carcinomas (SRC) and mucinous adenocarcinomas (MAC) are two relatively infrequent histological subtypes. However, little is known about the predictors of LNM and prognosis to support the feasibility of local excision in early-stage SRC and MAC. Methods: The Surveillance Epidemiology and End Results Database were used to identify all patients with pT1 adenocarcinomas, including conventional adenocarcinoma (AC), MAC, and SRC. The prevalence of LNM was assessed, and the long-term survival rate in the above three types of colorectal cancer was calculated. Results: SRC accounted for 0.3% and MAC accounted for 4.4% of the entire cohort of colorectal adenocarcinomas. Compared to AC, MRC and SRC were more often located in the proximal colon, and exhibited a higher grade. The incidence of LNM in AC, MAC, and SRC was 10.6%, 17.2%, and 33.3% for colon cancers and 14.8%, 25.9%, and 46.2% for rectal cancers, respectively. In patients with lymph nodes resected no less than 12, incidence of LNM in AC, MRC, and SRC was 12%, 21%, and 44% for colon tumors and 17%, 30%, and 14% for rectal tumors, respectively. Although, colon patients MAC showed an entirely worse survival rate than AC, rectum patients MAC showed a similar prognosis to AC. We found that in patients with rectal tumors, SRC had a worse 3 and 5-year prognosis than AC. However, for colon cancers, the prognosis of SRC was similar to that of AC. Histology was not found to be an independent prognostic factor in multivariate survival analysis. Conclusions: MAC and SRC are two distinct subtypes of colorectal cancer that require special attention despite their relatively rare prevalence. pT1 patients with SRC of the rectum and patients with MAC of the colon have higher incidences of LNM, and with these adverse outcomes, local excision is not recommended. AlthoughMAC of the rectum and SRC of colon have a high rate of LNM, the prognosis of these types are similar to that of AC.

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“…The second subtype of MCA is microsatellite stable, more frequently localized in the distal colorectum, shows normal expression of hMLH1 and p27, and has a worse outcome [29]. Another study, by Liu et al [36], distinguished MCAs according to aneuploid versus diploid status. Further clinicopathological and molecular analyses will help to clarify the role of the two subtypes of MCA.…”

Section: Mcamentioning

confidence: 99%

Mucinous Adenocarcinomas with Intra-Abdominal Dissemination: A Review of Current Therapy

Winder

Lenz

2010

The Oncologist

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Peritoneal carcinomatosis has been considered a terminal disease with a median survival time of 5.2-12.6 months. Systemic chemotherapy and cytoreductive surgery (CRS) have long been used to treat macroscopic disease, with limited success. However, a comprehensive treatment approach involving cytroreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) has evolved into a novel approach for peritoneal carcinomatosis. Surgery removes the primary cancer and any dissemination within the peritoneal cavity and adjuvant HIPEC eradicates macroscopic or microscopic tumor residue, thus reducing the risk for recurrence. This approach offers a new potential treatment option for patients with metastatic disease confined to the peritoneum. The present review provides an update of the most recent data on the current therapy for pseudomyxoma peritonei (PMP) and mucinous colorectal adenocarcinoma (MCA) with metastatic disease confined to the peritoneum. The Oncologist 2010;15:836 -844

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Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometry and comparative genomic hybridization

Cited by 14 publications

References 0 publications

Chromosomal analysis of Barrett's cells: demonstration of instability and detection of the metaplastic lineage involved

Chromosomal analysis of Barrett's cells: demonstration of instability and detection of the metaplastic lineage involved

Predictors of Lymph Node Metastasis and Prognosis in pT1 Colorectal Cancer Patients with Signet-Ring Cell and Mucinous Adenocarcinomas

Mucinous Adenocarcinomas with Intra-Abdominal Dissemination: A Review of Current Therapy

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