Two-stage polymer embossing of co-planar microfluidic features for microfluidic devices

Koesdjojo, Myra T.; Tennico, Yolanda H.; Rundel, Jack T.; Remcho, Vincent T.

doi:10.1016/j.snb.2008.01.008

Cited by 28 publications

(26 citation statements)

References 11 publications

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“…Microchips were fabricated from PMMA using a two-step embossing and solvent welding technique described previously [26,27]. The design of the microchip is shown in Fig.…”

Section: Microfluidic Device Fabricationmentioning

confidence: 99%

In‐line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis

Tennico

Remcho

2010

Electrophoresis

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An approach to performing in-line extraction employing functionalized magnetic particles for CE and microchip electrophoresis is presented. Silica-coated iron oxide particles were synthesized and used as the solid support. The particles were functionalized with octadecylsilane and used as reverse-phase sorbents for in-line SPE followed by electrophoresis. Magnets were used to locally immobilize these sorbents inside the capillary or microchip. Extraction, elution, and detection of the analytes were performed sequentially without interruption or need for sample handling. Mixtures of hydrophobic analytes were successfully extracted from solution using the synthesized magnetic sorbents. CE was able to extract and separate mixture of parabens within 10 min. In-line extraction was also carried out on a disposable PMMA microfluidic device with LIF detection. Electrophoretic separation of fluorescent dyes, Rhodamine 110 and SulfoRhodamine B, was completed in under a minute. The results demonstrated the feasibility of performing the in-line extraction/separation technique in a microchip platform enabling rapid analysis, low sorbent consumption, and increased analyte recovery (relative to the capillary format).

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“…Microchips were fabricated from PMMA using a two-step embossing and solvent welding technique described previously [26,27]. The design of the microchip is shown in Fig.…”

Section: Microfluidic Device Fabricationmentioning

confidence: 99%

In‐line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis

Tennico

Remcho

2010

Electrophoresis

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“…The key to the microfabrication in the plastic industry is the development of a precision mold to emboss microstructures. Several fabrication techniques have been proposed for micro-featured mold fabrication, including microcasting, silicon-based micromachining technology, lithographie galvanoformung abformung (LIGA), laser micromachining, micro-electro discharge machining (μ-EDM), micro machining, deep reactive ion etching, electrochemical micromachining, focused ion beam and wire electrical discharge machining [2][3][4][5][6][7][8][9][10][11][12][13]. Metal mold can be fabricated by mi-cro machining.…”

Section: Introductionmentioning

confidence: 99%

The evolution of manufacturing processes for micro‐featured epoxy resin mold

Kuo

Wang

Liao

et al. 2016

Materialwissenschaft Werkst

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Micro-injection molding or micro-hot embossing is a highly effective process for fabricating micro-devices with microfeatures in polymer. Based on the strong demand on the precision components in the precision machinery industrial, two major concerns are the time and expense required for producing a precision mold for microfabrication. To enhance the competitiveness in the market of micorcomponents, this study presents six approaches for manufacturing precision epoxy resin molds with microfeatures. Evolutions manufacturing processes are described experimentally. Characteristics and applications of micro-featured epoxy resin mold are introduced in detail.

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“…In hot embossing with metal master, 7 a master mold is imprinted on a plain PMMA substrate at glass transition temperature of PMMA. Generally direct structuring of this metal master is performed using mechanical machining or laser ablation.…”

Section: Introductionmentioning

confidence: 99%

A new fabrication technique to form complex polymethylmethacrylate microchannel for bioseparation

et al. 2012

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Recent studies show that reduction in cross-sectional area can be used to improve the concentration factor in microscale bioseparations. Due to simplicity in fabrication process, a step reduction in cross-sectional area is generally implemented in microchip to increase the concentration factor. But the sudden change in crosssectional area can introduce significant band dispersion and distortion. This paper reports a new fabrication technique to form a gradual reduction in cross-sectional area in polymethylmethacrylate (PMMA) microchannel for both anionic and cationic isotachophoresis (ITP). The fabrication technique is based on hot embossing and surface modification assisted bonding method. Both one-dimensional and twodimensional gradual reduction in cross-sectional area microchannels were formed on PMMA with high fidelity using proposed techniques. ITP experiments were conducted to separate and preconcentrate fluorescent proteins in these microchips. Thousand fold and ten thousand fold increase in concentrations were obtained when 10 Â and 100 Â gradual reduction in cross-sectional area microchannels were used for ITP.

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Two-stage polymer embossing of co-planar microfluidic features for microfluidic devices

Cited by 28 publications

References 11 publications

In‐line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis

In‐line extraction employing functionalized magnetic particles for capillary and microchip electrophoresis

The evolution of manufacturing processes for micro‐featured epoxy resin mold

A new fabrication technique to form complex polymethylmethacrylate microchannel for bioseparation

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