Two‐stage exposure of Syrian‐hamster‐embryo cells to environmental carcinogens: superinduction of ornithine decarboxylase correlates with increase of morphological‐transformation frequency

Dhalluin, Stéphane; Elias, Z.; Cruciani, Véronique; Bessi, Halima; Poirot, O.; Rast, C.; Gaté, Laurent; Pagès, Nicole; Tapiero, Haïm; Vasseur, Paule; Nguyen-Ba, G

doi:10.1002/(sici)1097-0215(19980302)75:5<744::aid-ijc13>3.3.co;2-c

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Although primarily used in transformation assays, two studies also examined SHE cells for chromosomal aberrations. These cells are representative of genetically stable diploid cells capable of activating a wide spectrum of chemical carcinogens and of undergoing apoptosis [48]. At concentrations that did not cause cytotoxicity or were near thresholds of reported precipitation (39 mg/ml), increased numbers of cells with chromatid gaps and isochromatid gaps were observed after 2 h incubation in vitro with S-9 and after 24 h without S-9 (0.39 mg/ml) [192].…”

Section: Chromosomal Effectsmentioning

confidence: 99%

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

Caldwell

2012

Mutation Research/Reviews in Mutation Research

193

101

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Section: Chromosomal Effectsmentioning

confidence: 99%

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

Caldwell

2012

Mutation Research/Reviews in Mutation Research

193

101

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“…Mechanistic studies include research on the understanding of the production and the target effects of free radicals, the cellular effects of proliferation and apoptosis, the formation of DNA adducts, the direct or indirect mutagenic effect on DNA, the change of gene expression, and the analysis of the physicochemical properties of susceptible particle surfaces to explain their differences in biologic activity. Only two types of tests can be used in in vitro carcinogenesis testing (22)(23)(24)(25): the morphologic transformation of mammalian cells in culture (26,27) and the inhibition of metabolic cooperation (28). Current research works use the survey of methodologic parameters to improve their predictiveness.…”

Section: Animal Experimentation Methodsmentioning

confidence: 99%

Occupational cancer in France: epidemiology, toxicology, prevention, and compensation.

Aubrun¹,

Binet²,

Bozec³

et al. 1999

Environ Health Perspect

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This article is a description of the current situation in France with regard to occupational cancer: research, prevention, and occupation. Toxicologic experiments are carried out using (italic)in vitro(/italic) and (italic)in vivo(/italic) tests, particularly using transgenic mice. Several epidemiologic studies have been conducted over the last decades: population-based case-control studies; mortality studies and cancer incidence studies carried out in historical cohorts of workers employed in the industry; and case-control studies nested in occupational cohorts. French ethical aspects of toxicologic and epidemiologic studies are described. The results thus obtained are used to establish regulations for the prevention and the compensation of cancers attributable to occupational exposure. This French regulation for prevention of occupational cancer involves several partners: (italic)a(/italic)) the states authorities, including labor inspectors, responsible for preparing and implementing the labor legislation and for supervising its application, particularly in the fields of occupational health and safety and working conditions; (italic)b(/italic)) the Social Security Organisation for the analysis of present or potential occupational risks based on tests, visits in plants, complaints or requests from various sources, and statistics. These activities are performed within the framework of the general French policy for the prevention of occupational cancer. This organization includes the National Institute for Research and Safety, particularly involved in research in the various fields of occupational risks--animal toxicology, biologic monitoring, exposure measurements epidemiology, psychology, ergonomy, electronic systems and machineries, exposure to chemicals, noise, heat, vibration, and lighting; and (italic)c(/italic)) companies where the regulation defines the role of the plant manager, the occupational physician, and the Health, Safety and Working Conditions Committee (comprising the manager, employees' representatives, the occupational physician, and the safety department) in dealing with any problem regarding safety, occupational hygiene, and working conditions. These organizations along with medical practitioners are involved with the compensation of occupational cancers. The regulation for compensation includes the tables of occupational cancer, the possibility of recognition of a cancer case when the requirements of the tables are not met, and the postprofessional follow-up of workers exposed to a carcinogenic agent.

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Two‐stage exposure of Syrian‐hamster‐embryo cells to environmental carcinogens: superinduction of ornithine decarboxylase correlates with increase of morphological‐transformation frequency

Cited by 2 publications

References 13 publications

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

DEHP: Genotoxicity and potential carcinogenic mechanisms—A review

Occupational cancer in France: epidemiology, toxicology, prevention, and compensation.

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