Two-stage autotransplantation of the human submandibular gland: First long-term results

Burghartz, Marc; Ginzkey, Christian; Hackenberg, Stephan; Hagen, Rudolf

doi:10.1002/lary.25854

Cited by 5 publications

(3 citation statements)

References 35 publications

(38 reference statements)

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“…Surgical transfer of one submandibular gland to the submental space has been shown to be superior to the administration of oral pilocarpine in the management of radiation-induced xerostomia (121,122). A pilot study of two-stage autologous transplantation of one submandibular gland to the forearm during radiation therapy and reimplantation of the gland to the floor of the mouth 2-3 months after radiation therapy has also indicated the potential to reduce radiation-induced salivary gland hypofunction and xerostomia (123,124).…”

Section: Surgical Transfer Of the Submandibular Glandmentioning

confidence: 99%

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients

et al. 2019

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Background The most manifest long-term consequences of radiation therapy in the head and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness (xerostomia). Methods This critical review addresses the consequences of radiation injury to salivary gland tissue, the clinical management of salivary gland hypofunction and xerostomia, and current and potential strategies to prevent or reduce radiation injury to salivary gland tissue or restore the function of radiation-injured salivary gland tissue. Results Salivary gland hypofunction and xerostomia have severe implications for oral functioning, maintenance of oral and general health, and quality of life. Significant progress has been made to spare salivary gland function chiefly due to advances in radiation techniques. Other strategies have also been developed, e.g., radioprotectors, identification and preservation/expansion of salivary stem cells by stimulation with cholinergic muscarinic agonists, and application of new lubricating or stimulatory agents, surgical transfer of submandibular glands, and acupuncture. Conclusion Many advances to manage salivary gland hypofunction and xerostomia induced by radiation therapy still only offer partial protection since they are often of short duration, lack the protective effects of saliva, or potentially have significant adverse effects. Intensity-modulated radiation therapy (IMRT), and its next step, proton therapy, have the greatest potential as a management strategy for permanently preserving salivary gland function in head and neck cancer patients. Presently, gene transfer to supplement fluid formation and stem cell transfer to increase the regenerative potential in radiation-damaged salivary glands are promising approaches for regaining function and/or regeneration of radiation-damaged salivary gland tissue.

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Section: Surgical Transfer Of the Submandibular Glandmentioning

confidence: 99%

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients

et al. 2019

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“…In head-and-neck radiotherapy, if the submandibular gland lies in the path of radiation, the gland can be surgically transferred to the submental region or transiently to a distant site such as the forearm so that it can be spared from the effects of radiation, thus preventing xerostomia. [ 2 3 36 ]…”

Section: Ethodologymentioning

confidence: 99%

Xerostomia – A Comprehensive Review with a Focus on Mid-Life Health

Jacob

Krishnan

Mathew

et al. 2022

Journal of Mid-Life Health

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Xerostomia is defined as the subjective complaint of a dry mouth. Xerostomia is common in menopausal women owing to the hormonal changes which take place during midlife. Studies show a higher incidence of oral cancer in the postmenopausal period which substantiates the theory of estrogen deficiency in carcinogenesis. Radiotherapy in the treatment of these cancers can lead to oral dryness. Other etiological factors of xerostomia include systemic diseases commonly occurring in middle-aged individuals and xerogenic drugs. Saliva plays a pivotal role in the maintenance of oropharyngeal health and xerostomia can severely impair the quality of life. The aim of this review was to provide vital information pertaining to the etiology, signs, diagnosis, and treatment of xerostomia with an emphasis on midlife health. The articles for this review were obtained from PubMed Central, Google Scholar, EBSCO, Science Direct, Medknow, Scopus, EMBASE, Web of Science, and authorized textbooks published between 1988 and 2021.

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“…This study showed that IR-induced SG hypofunction is reduced. However, forearm transfer could only serve as a potential preventive approach until further validation [ 87 , 88 ].…”

Section: Preventionmentioning

confidence: 99%

Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review

Pang

et al. 2022

Journal of Oncology

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In patients with head and neck cancer, irradiation (IR)-sensitive salivary gland (SG) tissue is highly prone to damage during radiotherapy (RT). This leads to SG hypofunction and xerostomia. Xerostomia is defined as the subjective complaint of dry mouth, which can cause other symptoms and adversely affect the quality of life. In recent years, diagnostic techniques have constantly improved with the emergence of more reliable and valid questionnaires as well as more accurate equipment for saliva flow rate measurement and imaging methods. Preventive measures such as the antioxidant MitoTEMPO, botulinum toxin (BoNT), and growth factors have been successfully applied in animal experiments, resulting in positive outcomes. Interventions, such as the new delivery methods of pilocarpine, edible saliva substitutes, acupuncture and electrical stimulation, gene transfer, and stem cell transplantation, have shown potential to alleviate or restore xerostomia in patients. The review summarizes the existing and new diagnostic methods for xerostomia, along with current and potential strategies for reducing IR-induced damage to SG function. We also aim to provide guidance on the advantages and disadvantages of the diagnostic methods. Additionally, most prevention and treatment methods remain in the stage of animal experiments, suggesting a need for further clinical research, among which we believe that antioxidants, gene transfer, and stem cell transplantation have broad prospects.

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Two-stage autotransplantation of the human submandibular gland: First long-term results

Abstract: 4. Laryngoscope, 126:1551-1555, 2016.

Cited by 5 publications

References 35 publications

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients

Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients

Xerostomia – A Comprehensive Review with a Focus on Mid-Life Health

Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review

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