Two-stage activated nano-truck enhanced specific aggregation and deep delivery for synergistic tumor ablation

Abstract

<p>Although nanomedicine has shown high performance in tumor theranostics, the anticancer activity is still limited by the drug delivery performance, especially lack of targeting capability, poor tumor accumulation, and insufficient...</p>

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

“…Given this paradigm, Zhang et al developed a nano-truck (BMP NT) with a two-stage delivery mechanism for synergistically enhanced PTT and SDT cancer treatment (Figure 6d). [78] Based on the Bi 2 S 3 -MnO 2 @BSA NP, a nanotruck was constructed with MMP-2-cleavable peptide substrate modified. With the enhanced permeability retention effect, the first "braking effect" was induced by tumor overexpressed MMP-2 removing the surface cleavable layer of BMP NTs.…”

“…Reproduced with permission. [ 78 ] Copyright 2020, Royal Society of Chemistry. e) CLSM images of KB cells stained by an Annexin VFITC/PI apoptosis detection kit.…”

“…(d) Schematic illustration of the two-stage process of BMP NTs in the tumor and the corresponding anticancer mechanism. Reproduced with permission [78]. Copyright 2020, Royal Society of Chemistry.…”

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

“…Highly dependent on transient thermoelastic expansion and acoustic waves induced by photoacoustic effect, PAI has both characteristics of USI and optical imaging for visualizing biological structures (Weber, Beard, & Bohndiek, 2016). In an interesting study, innovative MMP‐2 (a matrix metalloproteinase, overexpressed in human cancer) responsive peptide modified Bi 2 S 3 ‐MnO 2 NPs were constructed to availably enrich in tumors and realize MRI/PAI‐guided PTT/CDT (Zheng et al, 2020). Accompanied by the rapid degradation of Bi 2 S 3 ‐MnO 2 NPs inside the tumor region, released Mn (II) and Bi 2 S 3 NPs respectively served as a T1 MRI agent and a PAI agent to guide accurate PTT, subsequently accelerating Fenton‐like reaction.…”

“…(Reprinted with permission from Z. H. Zhao et al (2019). Copyright 2019, Elsevier; Zheng et al (2020). Copyright 2020, The Royal Society of Chemistry; M. Wang, Chang, et al (2020).…”