Two sources of dopamine for the hippocampus

McNamara, Colin G.; Dupret, David

doi:10.1016/j.tins.2017.05.005

Cited by 102 publications

(72 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Novel genetic and optogenetic techniques make it possible to study the function of neuromodulator nuclei with greater specificity (Carter et al, 2010;Eban-Rothschild et al, 2016). Using these methods, recent studies dissected VTA and LC projections in hippocampus and found that dopamine release from dense LC projections is the primary cause of learning and memory in certain tasks (Kempadoo et al, 2016;Takeuchi et al, 2016;McNamara and Dupret, 2017). Optogenetic stimulation of LC terminals in hippocampus enhanced DA together with NA and specific LC lesion reduced both neurochemicals (Kempadoo et al, 2016).…”

Section: Da and Na Co-release From The Locus Coeruleusmentioning

confidence: 99%

Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Ranjbar-Slamloo

Fazlali

2020

Front. Mol. Neurosci.

146

101

View full text Add to dashboard Cite

Dopamine and noradrenaline are crucial neuromodulators controlling brain states, vigilance, action, reward, learning, and memory processes. Ventral tegmental area (VTA) and Locus Coeruleus (LC) are canonically described as the main sources of dopamine (DA) and noradrenaline (NA) with dissociate functions. A comparison of diverse studies shows that these neuromodulators largely overlap in multiple domains such as shared biosynthetic pathway and co-release from the LC terminals, convergent innervations, non-specificity of receptors and transporters, and shared intracellular signaling pathways. DA-NA interactions are mainly studied in prefrontal cortex and hippocampus, yet it can be extended to the whole brain given the diversity of catecholamine innervations. LC can simultaneously broadcast both dopamine and noradrenaline across the brain. Here, we briefly review the molecular, cellular, and physiological overlaps between DA and NA systems and point to their functional implications. We suggest that DA and NA may function in parallel to facilitate learning and maintain the states required for normal cognitive processes. Various signaling modules of NA and DA have been targeted for developing of therapeutics. Understanding overlaps of the two systems is crucial for more effective interventions in a range of neuropsychiatric conditions.

show abstract

Section: Da and Na Co-release From The Locus Coeruleusmentioning

confidence: 99%

Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Ranjbar-Slamloo

Fazlali

2020

Front. Mol. Neurosci.

146

101

View full text Add to dashboard Cite

show abstract

“…Dopaminergic projections from both the substantia nigra pars compacta and the ventral tegmental area are important for memory processing. 12,13 Also, activation of cholinergic projections activation from the medial septum/diagonal band is sufficient to induce 40-Hz network oscillations in the hippocampus in vitro, thus playing an important role in hippocampal memory processing. 14 Serotonergic projections from the median raphe nucleus to the ventral hippocampus have also been consistently described 15 and are involved in the retrieval of fear memories.…”

Section: Novel Players In the Aging Synapsementioning

confidence: 99%

Novel Players in the Aging Synapse: Impact on Cognition

Temido‐Ferreira

Coelho

Pousinha

et al. 2019

Journal of Caffeine and Adenosine Research

View full text Add to dashboard Cite

While neuronal loss has long been considered as the main contributor to age-related cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction driven by calcium dyshomeostasis and alterations in ionotropic/metabotropic receptors. Given the key role of the hippocampus in encoding, storage, and retrieval of memory, the morpho-and electrophysiological alterations that occur in the major synapse of this network-the glutamatergic-deserve special attention. We guide you through the hippocampal anatomy, circuitry, and function in physiological context and focus on alterations in neuronal morphology, calcium dynamics, and plasticity induced by aging and Alzheimer's disease (AD). We provide state-of-the art knowledge on glutamatergic transmission and discuss implications of these novel players for intervention. A link between regular consumption of caffeine-an adenosine receptor blocker-to decreased risk of AD in humans is well established, while the mechanisms responsible have only now been uncovered. We review compelling evidence from humans and animal models that implicate adenosine A 2A receptors (A 2A R) upsurge as a crucial mediator of age-related synaptic dysfunction. The relevance of this mechanism in patients was very recently demonstrated in the form of a significant association of the A 2A R-encoding gene with hippocampal volume (synaptic loss) in mild cognitive impairment and AD. Novel pathways implicate A 2A R in the control of mGluR5-dependent NMDAR activation and subsequent Ca 2+ dysfunction upon aging. The nature of this receptor makes it particularly suited for long-term therapies, as an alternative for regulating aberrant mGluR5/NMDAR signaling in aging and disease, without disrupting their crucial constitutive activity.

show abstract

“…In particular, via its action on ß-adrenoceptors in the hippocampus, the LC modulates long-term potentiation (LTP) and long term-depression (LTD), key determinants of synaptic plasticity and memory 29,30 . Recent optogenetic work has confirmed a causal role of LC activity in hippocampal LTP and memory enhancement, potentially via co-release of dopamine [31][32][33] .…”

Section: Introductionmentioning

confidence: 99%

Higher rostral locus coeruleus integrity is associated with better memory performance in older adults

Dahl

Mather

Düzel

et al. 2018

Preprint

View full text Add to dashboard Cite

For decades, the search for drivers of memory decline in human cognitive aging has focused on neocortical regions, the hippocampus, and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in non-invasive monitoring of LC integrity have hindered the study of LC-cognition associations in humans so far. Using high-resolution neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in large samples of younger (n = 66), and older adults (n = 233). Moreover, we observed spatially confined and functionally relevant age differences in rostral LC. Older adults who showed a more youth-like rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in human aging and extend our knowledge about the role of the LC norepinephrine system in senescent decline in human cognition.

show abstract

Two sources of dopamine for the hippocampus

Cited by 102 publications

References 11 publications

Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?

Novel Players in the Aging Synapse: Impact on Cognition

Higher rostral locus coeruleus integrity is associated with better memory performance in older adults

Contact Info

Product

Resources

About