Higher rostral locus coeruleus integrity is associated with better memory performance in older adults

Dahl, Martin J.; Mather, Mara; Düzel, Sandra; Bodammer, Nils; Lindenberger, Ulman; Kühn, Simone; Werkle‐Bergner, Markus

doi:10.1101/332098

Cited by 8 publications

(15 citation statements)

References 93 publications

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“…In the BASE-II dataset, there were no significant differences between young and older adults' overall LC-MRI contrast values (Bachman et al, 2021;Dahl et al, 2019). We also did not observe significant associations between LC-MRI contrast and diffusivity in either the LC or ascending noradrenergic bundle.…”

Section: Lc-mri Contrasts and Dticontrasting

confidence: 46%

Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract

Porat

Sibilia

Yoon

et al. 2021

Preprint

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The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used three datasets (Berlin Aging Study-II, N = 301, the Leipzig Study for Mind-Body-Emotion Interactions, N = 220, and Stockholm Sleepy Brain, N = 49), to replicate published findings and expand them by investigating diffusivity in the LC’s ascending noradrenergic bundle. In younger adults, LC fractional anisotropy was significantly lower, compared to older adults. However, in the LC’s ascending noradrenergic bundle, we observed significantly higher fractional anisotropy in younger adults, relative to older adults. These findings indicate that diffusivity in the LC versus the ascending noradrenergic bundle are both susceptible to microstructural changes in aging that have opposing effects on fractional anisotropy.HighlightsFractional anisotropy in the locus coeruleus was lower in younger adultsFractional anisotropy in the noradrenergic bundle was higher in younger adultsSleep deprivation may affect diffusivity in younger adults more than older adults

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Section: Lc-mri Contrasts and Dticontrasting

confidence: 46%

Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract

Porat

Sibilia

Yoon

et al. 2021

Preprint

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“…For the in vivo imaging of the LC, neuromelanin-sensitive MRI protocols were developed ( Keren et al, 2009 ; Priovoulos et al, 2018 ; Sasaki et al, 2006 ) and validated with histology ( Keren et al, 2015 ). These MRI protocols have been applied successfully in various studies to quantify the morphometry and signal intensity changes due to aging ( Betts et al, 2017 ; Clewett et al, 2015 ; Dahl et al, 2019 ; Liu et al, 2019 ) and AD ( Betts et al, 2019 ; Olivieri et al, 2019 ; Takahashi et al, 2015 ). In addition, resting state fMRI (rsfMRI) was applied recently to examine the functional connectivity of LC ( Jacobs et al, 2018b ; Zhang et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease

Sun

Tang²,

Qiao

et al. 2020

NeuroImage

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“…The obtained LC signals are moderately consistent for scan-rescan reliability (Betts et al, 2017;Dahl et al, 2019;Langley et al, 2017;Tona et al, 2017) and achieve reliability indexes that are similar to those of bigger structures in less susceptible brain regions (Tona et al, 2017). Therefore, neuromelanin-sensitive MRI represents a promising, non-invasive method to determine structural alterations of the LC nucleus related to ageing or neurodegeneration.…”

Section: Figure 3 Neuromelanin-sensitive Mri Scansmentioning

confidence: 77%

“…Recently, neuromelanin-sensitive MRI was used to investigate the relationship between memory performance and LC integrity. Dahl et al (2019) reported that older participants showed better episodic memory when they had higher LC integrity.…”

Section: Figure 3 Neuromelanin-sensitive Mri Scansmentioning

confidence: 99%

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P1‐223: Functional Markers for Cerebral Norepinephrine Deficiency in Alzheimer’s Disease

Kiven

Loetgering

Kleineidam

et al. 2016

Alzheimer's & Dementia

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Background: In primary care units Frailty Ambulatory is dedicated to elderly people and is an example of health innovation. In the light of a complex rethinking of primary care, it is aimed to promote initiative medicine in the field of degenerative and chronic diseases. In short, Frailty Ambulatories have to make easier the "art" of caring elderly patients' complex needs through geriatricians and outof-hospital network services. The aim of the present study was to analyze data from 300 consecutive patients sent to our ambulatories. Methods:The starting point is caring patients and their needs. The first step is represented by over-65 year-old patients' selection according to the criteria of prefrailty and frailty (at least one Fried's criterion and the patient sent to geriatrician by general practitioner). Results:Of 300 patients, 118 (39,3%) were men, mean age 82,79 6 6,65 years old, BMI 22,176 2,15 kg/m 2 . After performing multidimensional assessment we found the following scores: MMSE 11,0562,44; ADL 0,9562,06; IADL 0,0460,188; CIRS 4,9561,72. The number of drugs used was 6,16 6 2,20. The most frequent Fried's criterion found was fatigue (97,3%, Table 1); criteria's mean/patient was 4,74 6 0,56. In 80,3% out of the patients all the five criteria were found, in 13.3% four criteria, in 6,4% three criteria (Figure 1). After bivariate relationship Fried's criteria were found to be significantly correlated to MMSE and heart failure. After multivariate analysis the relationship was kept with MMSE (beta -0,209; p¼0,0001). Conclusions: Experimental activity in Frailty Ambulatories could offer a tool able to recognize conditions of prefrailty/frailty. This can lead to a consistent and complete care response, preventing/decreasing disability conditions. Data analyses timely carried on by provincial health authority let plan the possible continuation of experimentation.Background:The locus coeruleus (LC) as the only source for norepinephrine (NE) in the human brain shows early degeneration in Alzheimer's disease (AD). The LC-NE system is involved in attentional processes and different behavioral and functional markers (e.g. evoked EEG potentials, BOLD responses, pupillary dilatation) have been identified as potential markers for LC-NEfunctionality. Here, we assessed whether these markers are characteristically altered in AD, thus providing potential surrogate markers for interventional trials targeting the LC-NE-system. Methods: We aim at including patients (planned: n¼30) with cerebrospinal fluid-biomarker evidence for AD and age-matched healthy controls (planned: n¼30). We obtain reaction times and accuracy, event-related electroencephalography (EEG) potentials (P300b), task-related pupil dilation and event-related blood oxygen level dependent (BOLD) responses in a stimulus detection task (Oddball-paradigm). Additionally, structural magnetic resonance imaging (MRI) with neuromelanine-sensitive sequences is applied to determine a volumetric measure for the LC. Here, we present preliminary results for 15 subjects with ...

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Higher rostral locus coeruleus integrity is associated with better memory performance in older adults

Cited by 8 publications

References 93 publications

Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract

Age Differences in Diffusivity in the Locus Coeruleus and its Ascending Noradrenergic Tract

A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease

P1‐223: Functional Markers for Cerebral Norepinephrine Deficiency in Alzheimer’s Disease

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