Two repetition time saturation transfer (TwiST) with spill-over correction to measure creatine kinase reaction rates in human hearts

Schär, Michael; Gabr, Refaat E.; El-Sharkawy, Abdel Monem M.; Steinberg, Angela; Bottomley, Paul A.; Weiss, Robert G.

doi:10.1186/s12968-015-0175-4

Cited by 28 publications

(30 citation statements)

References 25 publications

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“…Since 2000, four saturation‐transfer methodologies have been used to measure myocardial

k_{normalf}^{CK}

and CK flux in the human heart: The four‐angle saturation transfer (FAST) method, developed for

k_{normalf}^{CK}

measurement at 1.5T . Triple repetition time saturation transfer (TRiST), developed for 3T . Two repetition time saturation transfer (TwiST), developed for 3T (similar to TRiST but with decreased measurement duration) . Time‐dependent saturation transfer (TDST), implemented at 3T for reproducibility measurements of

k_{normalf}^{CK}

. …”

Section: Theorymentioning

confidence: 99%

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

Clarke

Robson

Neubauer

et al. 2016

Magnetic Resonance in Med

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PurposeWe present a new Bloch‐Siegert four Angle Saturation Transfer (BOAST) method for measuring the creatine kinase (CK) first‐order effective rate constant kf in human myocardium at 7 tesla (T). BOAST combines a variant of the four‐angle saturation transfer (FAST) method using amplitude‐modulated radiofrequency pulses, phosphorus Bloch‐Siegert normalB1+‐mapping to determine the per‐voxel flip angles, and nonlinear fitting to Bloch simulations for postprocessing.MethodsOptimal flip angles and repetition time parameters were determined from Monte Carlo simulations. BOAST was validated in the calf muscle of two volunteers at 3T and 7T. The myocardial CK forward rate constant was then measured in 10 volunteers at 7T in 82 min (after 1H localization).ResultsBOAST knormalfCK values were 0.281 ± 0.002 s−1 in the calf and 0.35 ± 0.05 s−1 in myocardium. These are consistent with literature values from lower fields. Using a literature values for adenosine triphosphate concentration, we computed CK flux values of 4.55 ± 1.52 mmol kg−1 s−1. The sensitive volume for BOAST depends on the B1 inhomogeneity of the transmit coil.ConclusionBOAST enables measurement of the CK rate constant in the human heart at 7T, with spatial localization in three dimensions to 5.6 mL voxels, using a 10‐cm loop coil. Magn Reson Med 78:20–32, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Since 2000, four saturation‐transfer methodologies have been used to measure myocardial

k_{normalf}^{CK}

and CK flux in the human heart: The four‐angle saturation transfer (FAST) method, developed for

k_{normalf}^{CK}

k_{normalf}^{CK}

. …”

Section: Theorymentioning

confidence: 99%

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

Clarke

Robson

Neubauer

et al. 2016

Magnetic Resonance in Med

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“…The second strategy further reduces the number of acquired spectra by assuming an intrinsic T 1 value for PCr. These methods include the two repetition time saturation transfer (TwiST) and T 1 nominal methods.…”

Section: Introductionmentioning

confidence: 99%

³¹P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo

et al. 2017

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Purpose To develop a 31P spectroscopic magnetic resonance fingerprinting (MRF) method for fast quantification of the chemical exchange rate between phosphocreatine (PCr) and ATP via creatine kinase (CK). Methods A 31P MRF sequence (CK-MRF) was developed to quantify the forward rate constant of ATP synthesis via CK ( kfCK), the T1 relaxation time of PCr ( T1PCr), and the PCr-to-ATP concentration ratio ( MRPCr). The CK-MRF sequence used a bSSFP-type excitation with ramped flip angles and a unique saturation scheme sensitive to the exchange between PCr and γATP. Parameter estimation was accomplished by matching the acquired signals to a dictionary generated using the Bloch-McConnell equation. Simulation studies were performed to examine the susceptibility of the CK-MRF method to several potential error sources. The accuracy of nonlocalized CK-MRF measurements before and after an ischemia-reperfusion (IR) protocol was compared to magnetization transfer (MT-MRS) method in rat hindlimb at 9.4 T (n=17). Reproducibility of CK-MRF was also assessed by comparing CK-MRF measurements to both MT-MRS (n=17) and four angle saturation transfer (FAST) methods (n=7). Results Simulation results showed that CK-MRF quantification of kfCK was robust with <5% error in the presence of model inaccuracies including dictionary resolution, metabolite T2 values, Pi metabolism, and B1 miscalibration. Estimation of kfCK by CK-MRF (0.38±0.02 s−1 at baseline and 0.42±0.03 s−1 post-IR) showed strong agreement with MT-MRS (0.39±0.03 s−1 at baseline and 0.44±0.04 s−1 post-IR). kfCK estimation was also similar between CK-MRF and FAST (0.38±0.02 s−1 for CK-MRF and 0.38±0.11 s−1 for FAST). The coefficient of variation from 20-s CK-MRF quantification of kfCK was 42% of that by 150-s MT-MRS acquisition and was 12% of that by 20-s FAST acquisition. Conclusion This study demonstrates the potential of a 31P spectroscopic MRF framework for rapid, accurate and reproducible quantification of chemical exchange rate of CK in vivo.

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“…Schar et al validated here a two-repetition time ST (TwiST) method, which omits the acquisition with γ-ATP saturation and short repetition time, but instead assumes an intrinsic relaxation time T 1 for PCr [183]. The pseudo-first-order rate constant k f obtained with TwiST was found to be the same as the one measured with the triple-repetition time ST (TRiST) method, but the acquisition was 9 min faster.…”

Section: Animal Studiesmentioning

confidence: 90%

Review of Journal of Cardiovascular Magnetic Resonance 2015

Pennell

Baksi

Prasad

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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There were 116 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2015, which is a 14 % increase on the 102 articles published in 2014. The quality of the submissions continues to increase. The 2015 JCMR Impact Factor (which is published in June 2016) rose to 5.75 from 4.72 for 2014 (as published in June 2015), which is the highest impact factor ever recorded for JCMR. The 2015 impact factor means that the JCMR papers that were published in 2013 and 2014 were cited on average 5.75 times in 2015. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is <25 % and has been falling because the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality papers to JCMR for publication.

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Two repetition time saturation transfer (TwiST) with spill-over correction to measure creatine kinase reaction rates in human hearts

Cited by 28 publications

References 25 publications

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

³¹P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo

Review of Journal of Cardiovascular Magnetic Resonance 2015

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Two repetition time saturation transfer (TwiST) with spill-over correction to measure creatine kinase reaction rates in human hearts

Cited by 28 publications

References 25 publications

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

31P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo

Review of Journal of Cardiovascular Magnetic Resonance 2015

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³¹P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo