Two-Photon Excitation for Bone Imaging: A New Application for Lanthanide Luminescence

Bettencourt‐Dias, Ana de

doi:10.1016/j.chempr.2016.08.019

Cited by 3 publications

(1 citation statement)

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“…Improving the performance of these complexes requires understanding of the sensitization mechanism, which is an intricate process dependent on the antenna, the complex structure, the chemical environment, the temperature, and the Ln-ion. − Excitation of the visible-emitting Lns is usually limited to UV-blue light. However, two-photon excitation with red/NIR light is increasingly widespread and avoids damage to biomolecules. − …”

Section: Introductionmentioning

confidence: 99%

Photophysics of Coumarin and Carbostyril-Sensitized Luminescent Lanthanide Complexes: Implications for Complex Design in Multiplex Detection

et al. 2017

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Luminescent lanthanide (Ln(III)) complexes with coumarin or carbostyril antennae were synthesized and their photophysical properties evaluated using steady-state and time-resolved UV-vis spectroscopy. Ligands bearing distant hydroxycoumarin-derived antennae attached through triazole linkers were modest sensitizers for Eu(III) and Tb(III), whereas ligands with 7-amidocarbostyrils directly linked to the coordination site could reach good quantum yields for multiple Ln(III), including the visible emitters Sm(III) and Dy(III), and the near-infrared emitters Nd(III) and Yb(III). The highest lanthanide-centered luminescence quantum yields were 35% (Tb), 7.9% (Eu), 0.67% (Dy), and 0.18% (Sm). Antennae providing similar luminescence intensities with 2-4 Ln-emitters were identified. Photoredox quenching of the carbostyril antenna excited states was observed for all Eu(III)-complexes and should be sensitizing in the case of Yb(III); the scope of the process extends to Ln(III) for which it has not been seen previously, specifically Dy(III) and Sm(III). The proposed process is supported by photophysical and electrochemical data. A FRET-type mechanism was identified in architectures with both distant and close antennae for all of the Lns. This mechanism seems to be the only sensitizing one at long distance and probably contributes to the sensitization at shorter distances along with the triplet pathway. The complexes were nontoxic to either bacterial or mammalian cells. Complexes of an ester-functionalized ligand were taken up by bacteria in a concentration-dependent manner. Our results suggest that the effects of FRET and photoredox quenching should be taken into consideration when designing luminescent Ln complexes. These results also establish these Ln(III)-complexes for multiplex detection beyond the available two-color systems.

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Section: Introductionmentioning

confidence: 99%

Photophysics of Coumarin and Carbostyril-Sensitized Luminescent Lanthanide Complexes: Implications for Complex Design in Multiplex Detection

et al. 2017

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Lanthanides and tissue engineering strategies for bone regeneration

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Staszak

Woźniak-Budych

et al. 2019

Coordination Chemistry Reviews

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Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

et al. 2023

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Conjugated polymers (CPs) have attracted much attention in the fields of chemistry, medicine, life science, and material science. Researchers have carried out a series of innovative researches and have made significant research progress regarding the unique photochemical and photophysical properties of CPs, expanding the application range of polymers. CPs are polymers formed by the conjugation of multiple repeating light-emitting units. Through precise control of their structure, functional molecules with different properties can be obtained. Fluorescence probes with different absorption and emission wavelengths can be obtained by changing the main chain structure. By modifying the side chain structure with water-soluble groups or selective recognition molecules, electrostatic interaction or specific binding with specific targets can be achieved; subsequently, the purpose of selective recognition can be achieved. This article reviews the research work of CPs in cell imaging, tumor diagnosis, and treatment in recent years, summarizes the latest progress in the application of CPs in imaging, tumor diagnosis, and treatment, and discusses the future development direction of CPs in cell imaging, tumor diagnosis, and treatment.

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Two-Photon Excitation for Bone Imaging: A New Application for Lanthanide Luminescence

Abstract: In this issue of Chem, Gunnlaugsson and colleagues show that using a luminescent Eu III cyclen complex with a sensitizer capable of two-photon excitation leads to unprecedented in-depth high-resolution imaging of microcracks in bone at a 750 nm excitation wavelength.

Cited by 3 publications

References 10 publications

Photophysics of Coumarin and Carbostyril-Sensitized Luminescent Lanthanide Complexes: Implications for Complex Design in Multiplex Detection

Photophysics of Coumarin and Carbostyril-Sensitized Luminescent Lanthanide Complexes: Implications for Complex Design in Multiplex Detection

Lanthanides and tissue engineering strategies for bone regeneration

Conjugated Polymeric Materials in Biological Imaging and Cancer Therapy

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