Lanthanides and tissue engineering strategies for bone regeneration

Wieszczycka, Karolina; Staszak, Katarzyna; Woźniak-Budych, Marta J.; Jurga, Stefan

doi:10.1016/j.ccr.2019.03.003

Cited by 35 publications

(15 citation statements)

References 177 publications

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“…First, we will discuss the effect of rare earth on bone regeneration, and later we will continue to discuss the effect of calcium released from bioactive glasses on bone cancer cells. Rare-earth ions, including Ho 3+ , have ionic radii similar to Ca 2+ , acting either as agonist or antagonist of Ca 2+ sites in biochemical pathways, and can stimulate pre-osteoblastic cell proliferation [ 71 ]. Recently, Zhu et al [ 72 ] showed that Gd 3+ ions leached from bioactive glasses could stimulate protein expression related to the Wnt signaling pathway, which is related to osteogenic differentiation of human bone marrow-derived mesenchymal stem cell.…”

Section: Discussionmentioning

confidence: 99%

Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment

et al. 2021

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Holmium-containing bioactive glasses can be applied in bone cancer treatment because the holmium content can be neutron activated, having suitable properties for brachytherapy applications, while the bioactive glass matrix can regenerate the bone alterations induced by the tumor. To facilitate the application of these glasses in clinical practice, we proposed a composite based on Poloxamer 407 thermoresponsive hydrogel, with suitable properties for applications as injectable systems. Therefore, in this work, we evaluated the influence of holmium-containing glass particles on the properties of Poloxamer 407 hydrogel (20 w/w.%), including self-assembly ability and biological properties. 58S bioactive glasses (58SiO2-33CaO-9P2O5) containing different Ho2O3 amounts (1.25, 2.5, 3.75, and 5 wt.%) were incorporated into the hydrogel. The formulations were characterized by scanning electron microscopy, differential scanning calorimetry, rheological tests, and [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] MTT cell viability against pre-osteoblastic and osteosarcoma cells. The results evidenced that neither the glass particles dispersed in the hydrogel nor the holmium content in the glasses significantly influenced the hydrogel self-assembly ability (Tmic ~13.8 °C and Tgel ~20 °C). Although, the glass particles considerably diminished the hydrogel viscosity in one order of magnitude at body temperature (37 °C). The cytotoxicity results evidenced that the formulations selectively favored pre-osteoblastic cell proliferation and osteosarcoma cell death. In conclusion, the formulation containing glass with the highest fraction of holmium content (5 wt.%) had the best biological results outcomes aiming its application as theragenerative materials for bone cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment

et al. 2021

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“…The biological properties of REEs derive from their similarity to other ions such as calcium, having been suggested displacement of the divalent charged Ca by the trivalent REE in Ca-binding sites in biological molecules (Jalali and Lebeau, 2021). In this context, the replacement of Ca 2+ by Ln 3+ ions in biological systems is a well-known strategy in medicine, and these ions' similarities were the precursor of studies on their potential use in medicine (Wieszczycka et al, 2019).…”

Section: Biological Functions and Accumulation In Marine Organismsmentioning

confidence: 99%

“…Current literature data indicate that REEs are present in almost all parts of the human body (Wieszczycka et al, 2019), suggesting that they could have a biological role, although a low level of REEs in human tissues and fluids indicates minimal transfer through the food chain. The concentration of REEs by a factor of 7 in drinking water has been suggested to potentially risk human health (Khan et al, 2017).…”

Section: Biological Functions and Accumulation In Marine Organismsmentioning

confidence: 99%

Review of the concentration, bioaccumulation, and effects of lanthanides in marine systems

et al. 2022

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Rare earth elements (REEs) or lanthanides are often found together in nature, and they are used in multiple anthropogenic activities from green energy and medical technologies to telecommunications and defense systems. However, the current understanding on the concentration and behavior of REEs in oceans and marine organisms is limited, and no regulatory information or limits have been settled. Here, we present a review of the concentrations of lanthanides in marine waters and biota. REEs reach aquatic ecosystems mainly by continental contributions, and the maximum reported concentrations of REEs are found on the platform surface near the coast due to their continental origin. For coastal waters, we find maximum REE levels in the surface water that decrease with depth until a certain stability. Their concentrations diminish as they move toward the open ocean, where concentrations tend to increase vertically with depth in the water column. Only cerium (Ce) showed different patterns from other REEs caused by Ce different redox states: III and IV, reflecting the oxidation of dissolved Ce (III) to particulate Ce (IV) when reacting with the O2 to form CeO2. In seawater, heavy REEs tend to remain in solution forming complexes usually unavailable for organisms, while light REEs are most likely to be assimilated by them, posing potential biological implications. Bioaccumulation of REEs decreases as marine trophic level increases, showing a trophic dilution pattern. Generally, higher concentrations are found in organisms such as phytoplankton, zooplankton, and algae species, while the lowest concentrations are found in mollusks, corals, and fish species. According to the current trend in the REE industry, the increasing anthropogenic emissions are a fact; therefore, more studies will be needed regarding their fractionation, the transformation processes with which they become bioavailable, and their pathways in marine systems.

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“…Several remarkable review articles have been published to emphasize the potential of lanthanide-related materials for bioimaging and biomedicine achievements. 4,[28][29][30] In this review, we will concentrate on the literature of the past few years covering the recent advances of lanthanide-based systems for the detection of biomolecules. We begin by surveying the recent advances in the designed UCNPs to detect biomolecules, including amino acids, proteins, tumor biomarkers, nucleic acids, and so on.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide upconversion and downshifting luminescence for biomolecules detection

et al. 2021

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Lanthanides and tissue engineering strategies for bone regeneration

Cited by 35 publications

References 177 publications

Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment

Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment

Review of the concentration, bioaccumulation, and effects of lanthanides in marine systems

Lanthanide upconversion and downshifting luminescence for biomolecules detection

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