“…For the early diagnosis of gastrointestinal/brain tumors, piezoelectric ceramic tube (PZT) fiber-optic scanning endomicroscopy has rapidly evolved, encompassing modalities such as endoscopic optical coherence tomography [1], confocal endomicroscopy [2,3], and nonlinear endomicroscopy [4,5]. Two-photon endomicroscopy (TPEM), founded upon the principle of two-photon fluorescence excitation [6], demonstrates distinct technological advantages, including deeper tissue penetration and label-free imaging, thus positioning it as a robust endomicroscopic technique for in-vivo imaging [7][8][9]. In comparison to the microelectromechanical scanning configuration, the PZT fiber scanning configuration adopts a straight cylindrical design, which enhances its compatibility for integration within miniature probe platforms.…”