“…As illustrated in Figure 1, Taxol™ can be viewed as a "level 11" taxane due to the presence of 9 oxidized carbon atoms and two degrees of unsaturation; over 100 natural products at this oxidation state have been isolated. Similarly, decinnamoyltaxinine E ( 2 ) 29 , taxabaccatin III ( 3 ) 30 , taxusin ( 4 ) 31–36 , taxuyunnanine D ( 5 ) 37,38 , and taxadiene ( 6 ) 39–41 can be viewed as level 3–5 taxanes and represent over 100 additional natural products. In this report, the first enantioselective total syntheses of decinnamoyltaxinine E ( 2 ) and taxabaccatin III ( 3 ) are presented.…”