Two-Phase Method for the Investigation of Interphase Transport: I: Theoretical Aspects

Kinetic and Thermodynamic Aspects of In Vitro Interphase Transfer of Tetracyclines II: Influence of Divalent Metal Salts

“…For all derivatives except tetracycline, the forward rate constants, k f , for transfer from aqueous to 1-octanol phases were decreased in the presence of the divalent metals. The interphase transfer rates are influenced by the thickness of the aqueous diffusion layer, which, in turn, depends on the agitation rate (12). The backward rate constants, kh, for transfer from 1-octanol to aqueous phases were also, again with the exception of tetracycline, subject to small but statistically significant decreases in the presence of the metals.…”

Two-Phase Method for the Investigation of Interphase Transport II: Experimental Aspects

“…Numerous advantages of film-coating techniques have been listed and contrasted to the timehonored technique or "art" of sugar coating (1,2). There appears to be, however, one feature lacking related to film coating.…”

Pharmaceutical Sciences-1969: Literature Review of Pharmaceutics

“…Deviation from first-order behavior occurs when the partition coefficient is low, when the diffusion coefficient in the oil is low, when the diffusion coefficient in the aqueous phase is large, or when the thickness of the aqueous diffusion layer is small. These results may be useful in the design and interpretation of both in uitro and in uiuo data on drug transport (1233). Similar investigations involving two-phase methods for investigation of the interphase transport of drugs were reported (1234, 1235).…”