Two-Phase Method for the Investigation of Interphase Transport II: Experimental Aspects

Howard, Stephen A.; Suzuki, Akira; Farvar, M.A.; Higuchi, William I.

doi:10.1002/jps.2600581107

Cited by 9 publications

(3 citation statements)

References 2 publications

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“…The applicability of equation 2 was tested by linear regression and found valid as shown below:P. B. McNulQ and M . Karelno SAA: l / K w = lo4 (0.253 $-2.8S/Kp) r = 0.998 + SAA: l/Kw = lo4 (0.329 + 2.91/Kp) r = 12, we estimated the stagnant layer thicknesses, Axo and Axw, for nhexanol transfer as follows :(13) Axo = .Do/ko = 0.0473 x 10-Axw = ow/k, = 0.805 X 10-5/3.04 X lop4 = 265 pm These values are within the ranges of 83-340 pm reported byHoward et al (1969) for the aqueous film thicknesses in their stirred cell studies. Comparison of experimental and predicted K , for mass transfer of n-alcohols from Wesson oil to water at 24°C.…”

supporting

confidence: 64%

Factors affecting flavour release and uptake in O/W emulsions:II. Stirred cell studies

McNulty

Karel

1973

Int J of Food Sci Tech

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Transport of organic solutes was investigated in stirred diffusion cells atRelease rates of n-alcohols ((2,-C,) from vegetable oil to water increased as chain length increased. The data were correlated satisfactorily with a modification of the Mayers correlation, in which transport is controlled by eddy diffusion. The permeability of the stagnant oil interfacial film was estimated from these data and compared with literature values of in vivo membrane permeabilities. To our surprise, no measurable uptake of cholesterol by vegetable oil was observed over 500 hr.Release rates of C, from silicone oils (linear polydimethysiloxanes) decreased by less than one order of magnitude when oil viscosity was increased from 48 to 93,000 cP, in contradiction to a Mayers correlation prediction. Release rates of C, from hydrogenated vegetable oils decreased by onle order of magnitude when the solid fat index was increased from 0 to 66.In all cases the presence of aqueous sodium sulphate or Tween 60 altered the transfer rates only because of the resultant oil-water partition coefficient alteration.

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confidence: 64%

Factors affecting flavour release and uptake in O/W emulsions:II. Stirred cell studies

McNulty

Karel

1973

Int J of Food Sci Tech

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“…The findings of this study have been correlated with the previous research in these laboratories and demonstrate when an oil-water interfacial barrier is rate determining (5-7) and when bulk matrix diffusional factors are dominant (1)(2)(3). These investigations (1-4) have considered, for example, the simultaneous multiphase interactions involving pH and the buffer decane were dispersed.…”

supporting

confidence: 81%

Interfacial Barriers in Interphase Transport III: Transport of Cholesterol and Other Organic Solutes into Hexadecane–Gelatin–Water Matrices

Ghanem

Higuchi

Simonelli

1970

Journal of Pharmaceutical Sciences

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“…Limited work has been reported on theoretical models and experimental explorations of the interfacial transfer of the drug across a liquid-liquid (L-L) interface. [15][16][17][18][19][20][21] In order to understand the transfer kinetics occurring at the L-L interface, it is necessary to develop a mathematical description which accurately depicts the interfacial processes. The resulting model needs to be sufficiently detailed based on first principles and free of empirical parameters so that the physical properties, kinetics, and operating conditions which affect the interfacial process can be correctly identified and quantified.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Partition Rate of Ibuprofen Across the Water-Octanol Interface and the Influence of Common Pharmaceutical Excipients

Shi

Gao

2019

Journal of Pharmaceutical Sciences

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This work reports the measurement of the partition rate of a model drug, ibuprofen (IBU), from aqueous solutions into octanol in the absence and presence of common pharmaceutical excipients including glucose, lactose, maltoheptaose, hydroxypropyl methylcellulose, polyvinylpyrrolidone, polyvinylpyrrolidoneevinyl acetate, hydroxypropyl methylcellulose AS, sodium dodecyl sulfate, Tween 80, and sodium taurocholate at varying concentrations. This attempts to assess the kinetic aspect of IBU partitioning across the water-octanol interface by applying a mechanistic model and to characterize the interfacial resistance. A significant reduction in P i across the water-octanol interface was observed with extremely low concentration of the selected excipients in the aqueous media. These results reveal the presence of a surface excess of adsorbed excipients at the water-octanol interface. The retardation of the P i of IBU was found to be sensitive to (1) the molecular weight or the degree of polymerization of these excipients, (2) the hydrodynamic condition of the experimental method, and (3) the pH of the aqueous media. Retardation of the P i of IBU in the presence of excipients observed in this study is proposed by a steric obstruction mechanism through the adsorbed surface excess layer of excipients located at the water-octanol interface.

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Two-Phase Method for the Investigation of Interphase Transport II: Experimental Aspects

Cited by 9 publications

References 2 publications

Factors affecting flavour release and uptake in O/W emulsions:II. Stirred cell studies

Factors affecting flavour release and uptake in O/W emulsions:II. Stirred cell studies

Interfacial Barriers in Interphase Transport III: Transport of Cholesterol and Other Organic Solutes into Hexadecane–Gelatin–Water Matrices

Characterization of the Partition Rate of Ibuprofen Across the Water-Octanol Interface and the Influence of Common Pharmaceutical Excipients

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