Two novel macrocyclic organotin (IV) carboxylates based on bipyrazoledicarboxylic acid derivatives: Syntheses, crystal structures and antifungal activities

Designing, physiochemical confirmation, evaluation of biological and in-silico potential of Triorganotin(IV) complexes

“…The existence of two strong vibrational bands with distinct absorptions in the range of 1300-1320 cm -1 and 1527-1535 cm -1 , which correspond to the symmetric (vCOOs) and asymmetric (vCOOas) stretching vibrational modes of the carboxyl group, respectively, promoted the formation of the Sn-O bond [46]. The Δv = νas(OCO) − νs(OCO), provides important evidence for the Sn-carboxyl coordination mode [47]. For chelating bidentate coordination, Δν ≤ 100 cm -1 , for bridging bidentate coordination, Δν = 100-150 cm -1 , and for ionic coordination, Δν ≥ 200 cm -1 , according to Nelson and coworkers [48].…”

Synthesis, characterization, X‐ray structure, DNA binding, antioxidant and docking study of new organotin(IV) complexes

“…Four milligrams of SS-DNA (salmon sperm, double stranded) was dissolved in 40 mL of double distilled water to produce SS-DNA solution and was stirred overnight before storing it at 4 C. The purity and DNA concentration of the above solution was determined using the previously described method 21,22 and was found to be 2 Â 10 À4 M. The drug was titrated against SS-DNA solution by adding different concentrations of DNA solution (5-25 M) to a constant concentration (0.1 mM) of synthesized ligand (H 2 L) and diorganotin(IV) complex (1-4) solution. The solutions S C H E M E 3 Numbering scheme of ligand (H 2 L) and organotin(IV) complexes (1)(2)(3)(4).…”

“…Keeping in view the rising demand for compounds that can target DNA, we have synthesized N 0 -(3,-5-dichloro-2-hydroxybenzylidene)2-phenylacetohydrazide and its diorganotin(IV) complexes (1)(2)(3)(4). The structural determination of these compounds was done by using infrared (IR), 1 H and 13 C nuclear magnetic resonance (NMR) spectroscopies, mass spectrometry and singlecrystal X-ray diffraction (XRD).…”

Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties

“…Recently, Dahmani et al [ 75 ] reported two new organotin (IV) bipyrazole-dicarboxylate macrocyclic complexes 156 and 157 ( Figure 44 ) by condensing of one equivalent of the bipyrazole-dicarboxylic acids 1,1′-(propane-1,3-diyl)bis(5-methyl-1 H -pyrazole-3-carboxylic acid) or 1,1′-(2-hydroxypropane-1,3-diyl)bis(5-methyl-1 H -pyrazole-3-carboxylic acid) with two equivalents of oxide di-(n-butyl)tin. These macrocycles possess an interesting fungicidal activity against the pathogenic strain Fusarium oxysporum f. sp.…”