Two new taraxasterol-type triterpenes fromPergularia tomentosagrowing wild in Algeria

Abstract

Two new triterpenes of the taraxasterol skeleton are isolated for the first time form Pergularia tomentosa L. of Algerian origin. The new compounds were named pergularine A and pergularine B. In addition, eight known compounds were isolated from the plant including oleic acid, (9Z,12Z)-octadecadienoic acid, α-amyrin, 3-acetyltaraxasterol, 3-taraxasterol, 16α-hydroxytaraxasterol-3-acetate, 3-epi-micromeric acid, and (9Z,12Z)-octadecadienoic acid glucoside. All known compounds are isolated for the first time from P. tomentosa L.

Triterpenoids

“…173 Psiguanin A, which is 2a,3b-dihydroxytaraxast-20-en-28-oic acid 714, has been found in the leaves of Psidium guajava. 315 Other new taraxastane derivatives include chlorotolpidiol 715 and tolpidiol A 716 from Tolpis proustii and Tolpis lagopoda, 320 pergularines A 717 and B 718 from Pergularia tomentosa 333 and calotroprocerol A 719, calotroprocerone A 720 and calotroproceryl acetates A 721 and B 722 from Calotropis procera. 334 Two taraxastane saponins with known genins have been found in the roots of Ilex pubescens.…”

The chemistry and biological activities of natural products from Northern African plant families: from Aloaceae to Cupressaceae

“…Two new taraxastane-type triterpenes (66 and 67), along with eight known compounds (68)(69)(70)(71)(72)(73)(74)(75) were isolated from Pergularia tomentosa (Asclepiadaceae) from Algeria. 76 The new compounds were named pergularine A (66) and pergularine B (67). The known compounds were oleic acid (68), (9Z,12Z)-octadecadienoic acid (69), a-amyrin (70), 3-acetyltaraxasterol (71), 3-taraxasterol (72), 16a-hydroxytaraxasterol-3-acetate (73), 3-epimicromeric acid (74) and (9Z,12Z)-octadecadienoic acid glucoside (75).…”

Cardenolide glycosides from the aerial parts of Pergularia tomentosa.L and their biological activities

“…Ghalakinoside was reported to be a cytotoxic cardiac glycoside [2], and a potential anticancer drug [2]. We have evaluated the extract of the aerial parts of P. tomentosa as a part of our ongoing search for novel phytochemicals from medicinal plants in Algerian ora (12,13]. Therefore, we reported the presence of a new cardenolide glycoside 1, along with ve other cardenolide glycosides that are already known: calactin 2, 12-hydroxycalotropin 3, 6'-hydroxycalactin 4, galakinoside 5, and uscharidin 6 (14,15].…”