Triterpenoids

Hill, Robert A.; Connolly, Joseph D.

doi:10.1039/c4np00101j

Cited by 56 publications

(34 citation statements)

References 320 publications

(154 reference statements)

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“…This pharmacological significance has made triterpenoids one of the most studied families of natural products in recent decades (Hill and Connolly, 2015;Han and Peng, 2014;Nazaruk and Borzym-Kluczyk, 2014;Salvador et al, 2014;Parmar et al, 2013;Petronelli et al, 2009).…”

Section: Introductionmentioning

confidence: 98%

Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749

et al. 2015

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Section: Introductionmentioning

confidence: 98%

Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749

et al. 2015

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“…Hence, a comprehensive medicinal chemistry tools and analysis methodology are employed herein to assess the various limonin biosynthetic products. Degraded limonoids (e.g., isobenzofuranones sharing structural features with limonoids [91]) and other tetranortriterpenoids extracted from different genera and/or not belonging to the limonin biosynthetic group will not be considered and hence readers are rather directed to relevant recent reviews [15,37,[92][93][94][95][96][97][98][99][100][101].…”

Section: Medicinal Chemistry Toolsmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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“…Also, they identified 13 phenolic compounds with higher concentration in the leaves (4.6 g kg −1 dry matter [DM]), from which 3.1 g kg −1 DM were sulfated flavonoids. A rare triterpenic ketone with pharmaceutical properties (Hill & Connolly 2015) was found at high concentrations (2.8 g kg −1 DM) in the roots, namely the molecule hop-17(21)-en-3-one (Vilela et al 2014). Rodrigues et al (2014) looked at the bioactivity of H. portulacoides extracts and found high radical scavenging activity (IC50 = 0.9 mg ml −1 ) against the radical ABTS and a decrease in nitric oxide production after incubation of macro phages with lipopolysaccharide and a chlo roform extract Cambrollé et al (2012a,b), Sousa et al (2010, 2011), Válega et al (2008a (IC50 = 109 µg ml −1 ), indicative of anti-inflammatory properties.…”

Section: The Potential Of Halimione Portulacoidesmentioning

confidence: 99%

Unravelling the potential of halophytes for marine integrated multi-trophic aquaculture (IMTA)— a perspective on performance, opportunities and challenges

Custódio¹,

Villasante²,

Cremades³

et al. 2017

Aquacult. Environ. Interact.

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The present study critically analyses peer-reviewed literature addressing the potential of halophytes to remediate nutrient-rich effluents from marine and coastal aquaculture, as well as the potential for their economic valorization, from human consumption to an untapped source of valuable secondary metabolites with pharmaceutical potential. The growing body of evidence discussed in this review supports the perspective that halophytes can become a new source of nutrition and other high-value compounds and be easily incorporated into saltwater-based integrated multi-trophic aquaculture (IMTA) systems. In this context, halophytes act as extractors of dissolved inorganic nutrients, primarily nitrogen and phosphate, usually wasted in marine aquaculture farms. Phytoremediation using halophytes has been proven to be an efficient solution, and several ways exist to couple this practice with land-based marine aquaculture systems, namely through constructed wetlands and aquaponics. Focusing research on ecosystem-based approaches to aquaculture production will provide valuable data for producers and policy makers in order to improve decision making towards a sustainable development of this economic sector. Ecointensification of aquaculture through IMTA will potentially increase the overall productivity and resilience of the sector, and halophytes, in particular, are on the verge of becoming key players for the diversification and promotion of land-based IMTA. This work specifically documents the uncharted potential of Halimione portulacoides, an important halophyte in European salt marsh ecosystems, as a new extractive species for IMTA.

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Triterpenoids

Cited by 56 publications

References 320 publications

Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749

Biotransformation of oleanolic and maslinic methyl esters by Rhizomucor miehei CECT 2749

The Chemistry and Pharmacology of Citrus Limonoids

Unravelling the potential of halophytes for marine integrated multi-trophic aquaculture (IMTA)— a perspective on performance, opportunities and challenges

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