The Precambrian-Cambrian boundary presents an interesting stratigraphic conundrum: the trace fossil used to mark and correlate the base of the Cambrian, Treptichnus pedum, is restricted to siliciclastic facies, whereas biomineralized fossils and chemostratigraphic signals are most commonly obtained from carbonate-dominated sections. Thus, it is difficult to correlate directly between many of the Precambrian-Cambrian boundary sections, and to assess details of the timing of evolutionary events that transpired during this interval of time. Thick sections in the White-Inyo region of eastern California and western Nevada, USA, contain mixed siliciclastic-carbonate lithofacies, and therefore promote correlation between these classic, well-studied lithologic end-members. An integrated stratigraphic approach was applied to the White-Inyo succession, combining lithologic, paleontologic, and chemostratigraphic data, in order to address the temporal framework within the basin, and to facilitate worldwide correlation of the boundary. Results from the southern Great Basin demonstrate that the negative δ13C excursion that is ubiquitous in carbonate-dominated successions containing small shelly fossils occurs within stratigraphic uncertainty of the first occurrence of T. pedum. This global geochemical marker thus provides a link with the primary biostratigraphic indicator for the Precambrian-Cambrian boundary.