Two new naphthoate derivatives from <i>Morinda officinalis</i>

Zhai, Hui-Juan; Ye, Guo-Hua; Xue, Jun-Juan; Yu, Jin‐Hai; Zhang, Yuying; Zhang, Hua

doi:10.1080/10286020.2019.1670648

Cited by 2 publications

(2 citation statements)

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“…[ 10‐12 ] The phytochemical investigation of Morinda species led to the isolation and identification of various secondary metabolites, including mornaphthoates A—F, marinoids A—G, monotropein, asperuloside tetraacetate, asperuloside, asperulosidic acid, and polysaccharides. [ 11‐15 ] Some of them displayed a series of biological activities, such as anti‐tumor, anti‐inflammatory, hepatoprotective, anti‐depression, and antibacterial effects. [ 12‐17 ]…”

Section: Background and Originality Contentmentioning

confidence: 99%

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Discovery of New Iridoids as Farnesoid X Receptor Agonists from Morinda officinalis: Agonistic Potentials and Molecular Stimulation

et al. 2021

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The investigation of Morinda officinalis led to the isolation of twelve compounds (1-12), including three new iridoid glycosides morindalins A-C (1-3) and nine known compounds (4-12). Their structural identifications were conducted using HRMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra as well as quantum chemical computations. Compound 6 displayed the most significantly agonistic activity against farnesoid X receptor (FXR) with an EC 50 value of 7.18 M, and its agonistic effect was verified through the investigation of FXR downstream target genes including small heterodimer partner 1 (SHP1), bile salt export pump (BSEP), and organic solute transporter subunit alpha and beta (OSTα and OSTβ). The potential interaction of compound 6 with FXR was analyzed by molecular docking and molecular dynamics stimulation, revealing that amino acid residues Leu287, Thr288, and Ser332 played a crucial role in the activation of compound 6 towards FXR. These findings suggested that compound 6 could be regarded as a potential candidate for the development of FXR agonists.

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Section: Background and Originality Contentmentioning

confidence: 99%

“…[ 11‐15 ] Some of them displayed a series of biological activities, such as anti‐tumor, anti‐inflammatory, hepatoprotective, anti‐depression, and antibacterial effects. [ 12‐17 ]…”

Section: Background and Originality Contentmentioning

confidence: 99%