Methyl 2-naphthoates with anti-inflammatory activity from Morinda officinalis

Anti‐inflammatory Polyketides from an Endophytic Fungus Chaetomium sp. UJN‐EF006 of Vaccinium bracteatum

“…In the present project, our chemical investigation into the fermentation of Chaetomium sp. UJN-EF006 derived from the leaves of V. bracteatum afforded ten polyketides including seven previously undescribed ones (1-7) and three known analogues aureonitol (8), [16] lunatinin (9) [19] and indole-3-acetic acid (10). [20] Our biological evaluations established that 1 and 4 displayed inhibitory effect on NO production induced by LPS in murine RAW264.7 macrophage cells.…”

“…As part of our recent years’ efforts to search for bioactive ingredients from medicinal herbs with dietary values, [8–11] we have lately isolated iridoids and lignans with diverse bioactivities as the major chemical constituents in the leaves of Vaccinium bracteatum [12] . Since plant‐derived endophytic fungi have emerged as an important source of bioactive natural products in the last two decades, [13–14] the chemical diversity of V. bracteatum metabolites has thus inspired us to start a project aiming to explore the bioactive metabolites produced by the endophytic fungi of this plant.…”

“…[5] In addition, the Chaetomium fungi are also famous in the scientific community for their ability to metabolize a variety of bioactive natural products especially cytochalasans and azaphilones, [6] and these two important groups of compounds have been considered to be suitable chemotaxonomic markers for genus Chaetomium. [7] As part of our recent years' efforts to search for bioactive ingredients from medicinal herbs with dietary values, [8][9][10][11] we have lately isolated iridoids and lignans with diverse bioactivities as the major chemical constituents in the leaves of Vaccinium bracteatum. [12] Since plant-derived endophytic fungi have emerged as an important source of bioactive natural products in the last two decades, [13][14] the chemical diversity of V. bracteatum metabolites has thus inspired us to start a project aiming to explore the bioactive metabolites produced by the endophytic fungi of this plant.…”

Natural epoxyquinoids: isolation, biological activity and synthesis. An update

“…New 2-naphthoate derivatives (+) and (−)-mornaphthoate K were isolated from the roots of a traditional Chinese herb Morinda officinalis. 47 (+)-Mornaphthoate K showed a nitric oxide production inhibitory effect in lipopolysaccharideinduced murine RAW 264.7 macrophages with an IC 50 value of 26 ± 2 μM. Moreover, (+)-mornaphthoate K exhibited dosedependent inhibition of the secretion of two pro-inflammatory cytokines, TNF-α and IL-6.…”