Two new isopimarane diterpenoids from the endophytic fungus Xylaria sp. SNB-GTC2501

Sorres, Jonathan; Nirma, Charlotte; Touré, Seindé; Éparvier, Véronique; Stien, Didier

doi:10.1016/j.tetlet.2015.06.022

Cited by 20 publications

(6 citation statements)

References 18 publications

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“…No isolated endophytic fungus presented antibacterial activity. Previous studies reported that the extract of endophytic fungi belonging to genera identified in our study inhibited E. coli, S. aureus and S. enteritidis (Vieira et al, 2012;Xing et al, 2011;Sorres et al, 2015;Yue et al, 2015;Hu et al, 2015;Kurzatkowski and Gębska-kuczerowska, 2015). However, those endophytic fungi were not isolated from E. erythropappus.…”

Section: Discussionsupporting

confidence: 61%

ENDOPHYTIC FUNGI COMMUNITY IN Eremanthus erythropappus TREE FROM ANTHROPOGENIC AND NATURAL AREAS OF MINAS GERAIS

Godinho

Santos

Gomes³

et al. 2019

CERNE

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Natural habitat was the area with the highest number of endophytic fungi genera recovered from E. erythropappus Some genera of endophytic fungi from E. erythropappus showed antagonism against phytopathogenic fungi The most of the endophytic fungi isolated from E. erythropappus belong to the Ascomycota phylum S. sclerotiorum was the most sensitive phytopathogen inhibited by endophytic fungi isolated from E.

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Section: Discussionsupporting

confidence: 61%

ENDOPHYTIC FUNGI COMMUNITY IN Eremanthus erythropappus TREE FROM ANTHROPOGENIC AND NATURAL AREAS OF MINAS GERAIS

Godinho

Santos

Gomes³

et al. 2019

CERNE

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“…However, their minimal inhibitory concentrations were more than 128 µg/mL. In addition, 4 and 12 were not cytotoxic towards MRC5 cells (IC 50 >100 µM) [65].…”

Section: Melleins From Fungimentioning

confidence: 89%

Melleins—Intriguing Natural Compounds

Reveglia

Masi²,

Evidente³

2020

Biomolecules

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Melleins are 3,4-dihydroisocoumarins mainly produced by fungi, but also by plants, insects and bacteria. These specialized metabolites play important roles in the life cycles of the producers and they are involved in many biochemical and ecological processes. This review outlines the isolation and chemical and biological characterizations of natural-occurring melleins from the first report of (R)-mellein in 1933 to the most recent advances in their characterization in 2019. In addition, the pathways that could be involved in mellein biosynthesis are discussed, along with the enzymes and genes involved.

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“…The other compounds were determined as 16-α-Dglucopyranosyloxyisopimar-7-en-19-oic acid (5), [9] xylabisboein B (6), [10] xylabisboein A (7), [10] xylarenolide (8), [11] methyl 4-(2-hydroxybutynoxy)benzoate ( 9), [12] 4-(2-hydroxybutynoxy)benzoic acid (10), [12] 5-hydroxymellein (11), [13] and 5-methylmellein (12). [13] Compound 13 was a yellow gum with the molecular formula C 14 H 14 O 4 established by HR-ESI-MS data.…”

Section: Resultsmentioning

confidence: 99%

Novel Antifungal and Antifeedant Metabolites from Penicillium chrysogenum Co‐Cultured with Nemania primolutea and Aspergillus fumigatus

Yang

Cen

et al. 2023

Chemistry & Biodiversity

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The endophyte Nemania primolutea, inhibited the growth of Penicillium chrysogenum in the coculture system. Four new compounds, nemmolutines A -B (1 -2), and penigenumin (3) from N. primolutea, penemin (4) from P. chrysogenum were isolated from the coculture. On the other hand, P. chrysogenum inhibited the Aspergillus fumigatus in the coculture. Induced metabolites (13-16) with monasone naphthoquinone scaffolds including a new one from P. chrysogenum were produced by the coculture of P. chrysogenum, and A. fumigatus. Interesting, cryptic metabolites penicichrins A -B isolated from wild P. chrysogenum induced by host Ziziphus jujuba medium were also found in induced P. chrysogenum cultured in PDB ordinary medium. So the induction of penicichrin production by supplementing with host extract occurred in the fungus P. chrysogenum not the host medium. The productions of penicichrins were the spontaneous metabolism, and the metabolites (13 -16) were the culture driven. Compounds 4, 6, 8, 10, 11, 14, and 15 showed significant antifungal activities against the phytopathogen Alternaria alternata with MIC S of 1 -8 μg/mL, and compounds 7, 9, and 12 indicated significant antifeedant activities against silkworms with feeding deterrence indexes (FDIs) of 92 %, 66 %, and 64 %. The carboxy group in 4-(2-hydroxybutynoxy)benzoic acid derivatives, and xylabisboeins; the hydroxy group in mellein derivatives; and the quinoid in monasone naphthoquinone increased the antifungal activities.

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Two new isopimarane diterpenoids from the endophytic fungus Xylaria sp. SNB-GTC2501

Cited by 20 publications

References 18 publications

ENDOPHYTIC FUNGI COMMUNITY IN Eremanthus erythropappus TREE FROM ANTHROPOGENIC AND NATURAL AREAS OF MINAS GERAIS

ENDOPHYTIC FUNGI COMMUNITY IN Eremanthus erythropappus TREE FROM ANTHROPOGENIC AND NATURAL AREAS OF MINAS GERAIS

Melleins—Intriguing Natural Compounds

Novel Antifungal and Antifeedant Metabolites from Penicillium chrysogenum Co‐Cultured with Nemania primolutea and Aspergillus fumigatus

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