Two new genotypes of Plasmodium vivax circumsporozoite protein found in the Republic of Korea

Kho, Weon-Gyu; Park, Yeong-Hong; Chung, Jinwook; Kim, Jong-Pil; Hong, Sung-Tae; Lee, Won-Ja; Kim, Tong‐Soo; Lee, Jong-Soo

doi:10.3347/kjp.1999.37.4.265

Cited by 28 publications

(42 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 Moreover, the use of antimalarial chemoprophylaxis can change the pattern of malaria oct t currence. Although genetic evidence suggests that retemergent P. vivax has a Chinese or Democratic People's Republic of Korean origin, 17,18 genetic variation might have arisen in response to chemot t prophylaxis or climate change. A recent study demonstrated that the merozoite surface protein (MSP) gene nucleotide sequence of P. vivax in ROK is similar to that of Thai isolates.…”

Section: Discussionmentioning

confidence: 99%

Chemoprophylaxis and the epidemiological characteristics of re-emergent P. vivax malaria in the Republic of Korea

Kim

Shin

Yong

et al. 2006

Bull World Health Organ

View full text Add to dashboard Cite

Objective In the Republic of Korea (ROK), soldiers stationed where there is a risk of contracting malaria have received antimalarial chemoprophylaxis since 1997. However, chemoprophylaxis may facilitate the development of drug resistance, and late primary attacks in individuals who have received chemoprophylaxis are becoming more frequent. We investigated the association between chemoprophylaxis and the epidemiological characteristics and effectiveness of treatment for re-emergent Plasmodium vivax malaria, using a nationwide malaria database. Methods Among soldiers at risk of malaria between 1999 and 2001, we reviewed all P. vivax malaria cases (1158) that occurred before 31 December 2003. Early and late primary attacks were defined as cases occurring < 2 or > 2 months after the last day of exposure to risk of malaria, respectively. Findings Of these cases, 634 (72.0%) had received chemoprophylaxis, and 324 (28.0%) had not. Cases occurred mostly in summer, with a peak in July-August. Stratification by chemoprophylaxis history revealed different times to onset. Early primary attacks were more prevalent in the group not receiving chemoprophylaxis, while in the group receiving chemoprophylaxis most cases were late primary attacks. Of the latter, 312 out of 461 (67.7%) did not take primaquine regularly. After treatment of the first attack, 14 (1.2%) of 1158 were re-treated; all re-treated cases were cured using the same doses and regimen used for the first treatment. Conclusion In ROK, the increase in late primary episodes of re-emergent P. vivax malaria is associated with the use of antimalarial chemoprophylaxis.Bulletin of the World Health Organization 2006;84:827-834.Voir page 833 le résumé en français. En la página 833 figura un resumen en español. IntroductionPlasmodium vivax, the causative agent of vivax malaria, has been endemic in the Republic of Korea (ROK) for cent t turies. The number of cases of endemic malaria began to decline in the 1960s, partly due to increased socioeconomic development, increased use of agricult t tural pesticides, and the efforts of the National Malaria Eradication Service. These factors contributed to the eradicat t tion of malaria in the ROK, resulting in the declaration by WHO in 1979 that the country was malariatfree. 1 In 1993, one case of malaria attributed to autot chthonous transmission was detected near the demilitarized zone (DMZ) that separates ROK (south) from the Democratic People's Republic of Korea (north).2 Since 1993, the number of malaria cases has increased exponentially, particularly among soldiers based near the DMZ. [1][2][3][4][5] Chemoprophylaxis and the epidemiological characteristics of re-emergent P. vivax malaria in the Republic of Korea In ROK, healthy males aged over 18 years serve 26 months of mandat t tory military duty; most are stationed throughout their service near the DMZ, where the risk of malaria is highest. After finishing their military duty, the soldiers return from these risk areas to areas with little or no malaria. To reduce the occurren...

show abstract

Section: Discussionmentioning

confidence: 99%

Chemoprophylaxis and the epidemiological characteristics of re-emergent P. vivax malaria in the Republic of Korea

Kim

Shin

Yong

et al. 2006

Bull World Health Organ

View full text Add to dashboard Cite

show abstract

“…Two predominant allelic variants with minor variations in nucleotide sequences in the VK210 genotype have been identified in all South Korean isolates; the nonapeptide sequences are repeated 18 times in South Korean type A (SKA) (or KPVCSP96-6) and 20 times in South Korean type B (SKB) (or KPVCSP96-11) [12][13][14]. No cases of VK247 or of the mixed type have been found in South Korean P. vivax [12]. Similarly, the VK210 type variant is predominant in Azerbaijan strains, as in the South Korean isolates [26].…”

Section: Cspmentioning

confidence: 99%

“…PvCSP SKA (or KPVCSP96-6) and SKB (or KPVCSP96-11) alleles from current South Korean isolates are similar to those from Chinese (CH-5) and North Korean isolates, respectively [12][13][14]. CH-5 and North Korean isolates are classified as the East Asian group and the apparent genetic similarities are explained as due to regional proximity [12].…”

Section: Cspmentioning

confidence: 99%

“…CSP is also a prime candidate antigen for vaccines being developed for malaria, and an anti-CSP vaccine has successfully completed Phase III clinical trials [25]. South Korean P. vivax isolates contain unique PvCSP polymorphisms in the CR domain, and in the pre-and post-repeat regions [12][13][14]. Two predominant allelic variants with minor variations in nucleotide sequences in the VK210 genotype have been identified in all South Korean isolates; the nonapeptide sequences are repeated 18 times in South Korean type A (SKA) (or KPVCSP96-6) and 20 times in South Korean type B (SKB) (or KPVCSP96-11) [12][13][14].…”

Section: Cspmentioning

confidence: 99%

“…To date, the following antigenic markers have been tested and reported for Korean P. vivax (Table 1): circumsporozoite protein (CSP), merozoite surface protein 1 (MSP-1) and MSP-3, Duffy binding protein (DBP), apical membrane antigen 1 (AMA-1), and GAM-1 [12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax

2009

Self Cite

View full text Add to dashboard Cite

The high levels of antigenic polymorphism found in most P. vivax parasites indicate the development of sophisticated evasion of the human immune system [8]. Detailed knowledge of this genetic variation and comparisons of inter-and intra-speciesspecific levels of gene variation will both resolve epidemiological questions about parasite origin and provide tools with which to design an effective vaccine. Polymorphic repetitive sequences, Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivaxKorean J Parasitol. Vol. 47, Supplement: S51-S58, October 2009 DOI: 10.3347/kjp.2009 Abstract: Plasmodium vivax, a protozoan malaria parasite of humans, represents a major public health concern in the Republic of Korea (= South Korea). However, little is known about the genetic properties and population structures of the P. vivax isolates circulating in South Korea. This article reviews known polymorphic genetic markers in South Korean isolates of P. vivax and briefly summarizes the current issues surrounding the gene and population structures of this parasite. The critical genetic characteristics of major antigens of the parasite, such as circumsporozoite protein (CSP), merozoite surface protein 1 (MSP-1) and MSP-3, Duffy binding protein (DBP), apical membrane antigen 1 (AMA-1), and GAM-1, are also discussed.

show abstract

Analysis of the Plasmodium vivax apical membrane antigen-1 gene from re-emerging Korean isolates

Chung

Chun

et al. 2003

Parasitol Res

Self Cite

View full text Add to dashboard Cite

Apical membrane antigen-1 is a candidate vaccine component for malaria. In the present study, we investigated the polymorphism of the Plasmodium vivax apical membrane antigen-1 gene ( PvAMA-1) in 30 Korean isolates. The polymorphic region of the PvAMA-1 gene, corresponding to nucleotides 324-735 (aa 108-245), was amplified using polymerase chain reaction followed by cloning and sequencing. Two genotypes ( SKA and SKG) were identified on the basis of amino acid substitution. These were identical to those of the Chinese isolates. The Korean isolates showed sequence variation at six positions on the basis of the sequence of the Sal1 strain. Of these, variation at position 189 (Glu/Lys) was found only in SKA. These two genotypes were related to the genotype of the circumsporozoite and Duffy binding protein of the Korean isolate. These findings suggest that two genotypes of P. vivax coexist in the endemic area and that the re-emerging parasite in Korea may be related to or have originated in East Asia.

show abstract

Two new genotypes of Plasmodium vivax circumsporozoite protein found in the Republic of Korea

Cited by 28 publications

References 17 publications

Chemoprophylaxis and the epidemiological characteristics of re-emergent P. vivax malaria in the Republic of Korea

Chemoprophylaxis and the epidemiological characteristics of re-emergent P. vivax malaria in the Republic of Korea

Genetic Characteristics of Polymorphic Antigenic Markers among Korean Isolates of Plasmodium vivax

Analysis of the Plasmodium vivax apical membrane antigen-1 gene from re-emerging Korean isolates

Contact Info

Product

Resources

About