2003
DOI: 10.1007/s00436-002-0777-2
|View full text |Cite
|
Sign up to set email alerts
|

Analysis of the Plasmodium vivax apical membrane antigen-1 gene from re-emerging Korean isolates

Abstract: Apical membrane antigen-1 is a candidate vaccine component for malaria. In the present study, we investigated the polymorphism of the Plasmodium vivax apical membrane antigen-1 gene ( PvAMA-1) in 30 Korean isolates. The polymorphic region of the PvAMA-1 gene, corresponding to nucleotides 324-735 (aa 108-245), was amplified using polymerase chain reaction followed by cloning and sequencing. Two genotypes ( SKA and SKG) were identified on the basis of amino acid substitution. These were identical to those of the… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
34
0
1

Year Published

2004
2004
2013
2013

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 25 publications
(35 citation statements)
references
References 16 publications
0
34
0
1
Order By: Relevance
“…Our aim was to determine genetic diversity, which can show whether P. vivax malaria in Korea has become heterogeneous. Genetic studies of P. vivax malaria in Korea have been performed by using several parasitic proteins, including CSP, 17 Duffy-binding protein, 18 apical membrane antigen-1, 19 18S ribosomal RNA, 20 and MSP-1. 9 However, these studies focused on simple polymorphism analysis for each gene over a short period.…”
Section: Discussionmentioning
confidence: 99%
“…Our aim was to determine genetic diversity, which can show whether P. vivax malaria in Korea has become heterogeneous. Genetic studies of P. vivax malaria in Korea have been performed by using several parasitic proteins, including CSP, 17 Duffy-binding protein, 18 apical membrane antigen-1, 19 18S ribosomal RNA, 20 and MSP-1. 9 However, these studies focused on simple polymorphism analysis for each gene over a short period.…”
Section: Discussionmentioning
confidence: 99%
“…It seems to play a role in erythrocyte and hepatocyte invasion (Hodder et al 2001, Silvie et al 2004. A number of studies have addressed polymorphism in that PvAMA-1 encoding gene in various parts of the world, such as Asia, Oceania and South America , Figtree et al 2000, Han et al 2002, Chung et al 2003, Rodrigues et al 2005, Gunasekera et al 2007, Rajesh et al 2007, Grynberg et al 2008, Thakur et al 2008, Moon et al 2010). The PvAMA-1 protein includes three extracellular domains, known as domains I, II and III (Pizarro et al 2005) (Fig.…”
Section: Memmentioning
confidence: 99%
“…Variation at the position of amino acid residue 189 (Glu Lys) has been found only in SKOR type I (or SKA). Comparison of 219 sequences of isolates collected from 9 countries revealed that the PvAMA-1 polymorphism in Korean isolates is similar to that in 2 Chinese isolates [18,19]. SKOR type I (or SKA) is identical to AAP, and SKOR type II (or SKG) is identical to an AAN haplotype of Chinese isolates.…”
Section: Ama-1mentioning
confidence: 79%
“…Sequence analyses of the polymorphic region corresponding to nucleotides 324-735 (amino acids 108-245) of the PvAMA-1 gene have indicated on the basis of an amino acid residue substitution that 2 genotypes are present in South Korean isolates [18,19]. The Korean isolates contain non-synonymous sequence variations at 3 different positions as compared to the Belem strain.…”
Section: Ama-1mentioning
confidence: 99%
See 1 more Smart Citation