Two new furostanol saponins from<i>Tribulus terrestris</i>

Xu, Yun; Tian, Xu; Zhou, Haiou; Li, Bo; Xie, Shengxu; Si, Yun-Shan; Liu, Yue; Liu, Tonghua; Xu, Dongming

doi:10.1080/10286021003747458

Cited by 18 publications

(10 citation statements)

References 11 publications

(8 reference statements)

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“…Majorly present are furostanol glycosides including protodioscin and protogracillin, of which protodioscin is the most dominant saponin and spirostanol glycosides are present in small quantities. [78] Wu et al . found that the quantity of main ﬂavonoids is about 1.5 times that of main saponins.…”

Section: Chemical Constituentsmentioning

confidence: 99%

Phytopharmacological overview of Tribulus terrestris

et al. 2014

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Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, anti-inflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its value-added utility, eventually leading to higher revenues from the plant.

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Section: Chemical Constituentsmentioning

confidence: 99%

Phytopharmacological overview of Tribulus terrestris

et al. 2014

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“…The maximum accumulation of tribulosin for the Bulgarian sample was in the preflowering stage and the minimum was in the flowering-seeding stage. 15,24 Tribulus terrestris fruits in China were intensively examined between 2008 and 2010 [71][72][73][74][75][76][77][78][79]106 (Table 1). These researchers established new steroidal saponins for the species: triboloside D and E, terrestroside A, tribufurosides D and E, chloromaloside E, and others (Table 1).…”

Section: Presence Of Chemoraces According To Geographical Originmentioning

confidence: 99%

Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review

Semerdjieva

Zheljazkov

2019

Natural Product Communications

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Tribulus terrestris L. (TT) (puncturevine) is a common weed that grows in many countries worldwide and in some places is considered as a noxious weed. The plant has been used in traditional Chinese and Indian medicines and is now considered as one of the most popular aphrodisiacs. It is known for its healing properties for sexual difficulties, impotence, and human and animal hormonal imbalance. It is also used as a sexual booster. Because of the plant’s active substances that can be used for curing sexual and other disorders, interest in it is increasing, and it is currently one of the most studied medicinal plants. The products and preparations manufactured from the aboveground plant parts are especially popular among athletes and people with health issues and diseases such as hormonal imbalance, sexual problems, heart problems, and various kidney and skin diseases. The aim of this review is a comprehensive and critical assessment of the scientific publications involving TT, with special reference to its chemical constituents and biological properties that may facilitate current understanding and future studies of this fascinating plant species. The objectives of this review were (1) to find knowledge gaps, (2) to discuss critically relevant publications and issues with materials and methods that may be prerequisites for contradictory results, and (3) to identify research and development areas. It was found that some of the studies on TT extracts as aphrodisiacs are controversial. A significant number of research publications claim that TT extracts and nutritional supplements containing TT improve muscle tone, have a common biostimulating effect, and improve spermogenesis. However, there are a growing number of publications that dispute these claims, as there are no empirical data on commonly accepted mechanisms of action. The main biologically active substances in TT are steroidal saponins, flavonoids, alkaloids, and lignan amides, the most studied being the steroidal saponins. Multiyear data on the metabolic profile of the species are generally lacking. There are a variety of methods used for extracting plant material, differences in methodologies and saponin analyses, and scientific instruments that were used. Lack of common standards could be a reason for differences in the pharmacological activity and composition of the TT preparations. Development of standard procedures and methods for collection of plant material and analyses are recommended. Selection and breeding efforts and agronomic studies of promising clones of TT would need to be conducted in order to develop TT as a new crop. This will provide consistency of supply and quality of the feedstock for the pharmaceutical industry and could provide a new cash crop for growers.

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“…It has been used as an aphrodisiac, diuretic, antihypertension, antimicrobial, antiacetylcholine, hemolytic and anthelmintic substance as well as to treat coughs, kidney failure and cancer [1][2][3]. The biologically active compounds in TT are considered to be the steroidal saponins [4].…”

Section: Tribulus Terrestris Lmentioning

confidence: 99%

“…(TT) is a herb, widely spread in Mediterranean region, Southern Asia and Africa [1]. It has been used as an aphrodisiac, diuretic, antihypertension, antimicrobial, antiacetylcholine, hemolytic and anthelmintic substance as well as to treat coughs, kidney failure and cancer [1][2][3].…”

Section: Tribulus Terrestris Lmentioning

confidence: 99%

Changes in gene expression of CXCR4, CCR7 and BCL2 after treatment of breast cancer cells with saponin extract from Tribulus terrestris

Goranova¹,

Ss²,

Vs³

et al. 2015

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Saponins are natural substances produced by a large number of plants, one of which is Tribulus terrestris L. (TT). They have been reported to possess an antitumor activity exerted by regulating various signaling pathways in the cell. Although the mechanisms of action of saponin extracts from various plants have been widely studied, limited data are available about TT. The present study aimed to analyze the impact of saponin extract from TT on cell processes in breast carcinoma cell lines. The variations in expression of a group of 32 selected genes were examined by real-time PCR after saponin treatment of MCF7 and MCF10A cell lines. Only three genes -CXCR4, CCR7 and BCL2, showed changes in their mRNA levels after the application of the herb extract. While CXCR4 expression was reduced in both cell lines, CCR7 and BCL2 levels decreased only in tumorigenic MCF7 cells, implying cell-specificity of the saponin action. Our results suggested that TT extract containing saponins was likely to affect the processes of apoptosis and metastasizing of cancer cells. Further in vivo studies will show its applicability as an anticancer therapeutic agent.

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Two new furostanol saponins fromTribulus terrestris

Cited by 18 publications

References 11 publications

Phytopharmacological overview of Tribulus terrestris

Phytopharmacological overview of Tribulus terrestris

Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review

Changes in gene expression of CXCR4, CCR7 and BCL2 after treatment of breast cancer cells with saponin extract from Tribulus terrestris

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